Gut bacteria may shield against antipsychotic weight gain

NCT ID NCT07606014

Recruiting now Prevention Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if a daily probiotic powder can prevent or reduce weight gain, high blood sugar, and high cholesterol caused by certain antipsychotic drugs. About 112 adults starting or recently starting olanzapine, quetiapine, risperidone, or clozapine will take either the probiotic or a placebo for 12 weeks. Researchers will track changes in weight, blood sugar, and other metabolic markers to see if the probiotic helps.

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Conditions

The condition(s) this trial relates to.

metabolic syndrome X psychotic disorder Psychotic Disorders Schizophrenia Weight Gain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PATIENTS USING OLANZAPINE, QUETIAPINE, RISPERIDONE OR CLOZAPINE

Contacts and locations

Locations

Antes Parnassia Groep
RECRUITING

Rotterdam, South Holland, 3083AK, Netherlands
KieN VIP Leeuwarden
RECRUITING

Leeuwarden, Provincie Friesland, 8911KJ, Netherlands
University Medical Center Groningen
RECRUITING

Groningen, Provincie Groningen, 9713GZ, Netherlands

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