Can a new antibody slow Alzheimer's? large trial begins

NCT ID NCT07169578

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This Phase 3 trial tests trontinemab, an antibody given by IV, in 800 people with early Alzheimer's (mild cognitive impairment to mild dementia). Half get the drug, half get a placebo, for 72 weeks. The goal is to see if it slows decline in memory, thinking, and daily activities.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trontinemab (a lab-made antibody given by IV infusion)
What this could lead to: If it works, this could slow memory loss and daily function decline in people with early Alzheimer's, offering a new treatment option.
What could go wrong: This is a large Phase 3 trial, but Alzheimer's drugs have often failed before. The benefit may be modest, and side effects like brain swelling or bleeding are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMERS DISEASE

Contacts and locations

Locations

Accel Research Sites-NeuroStudies
RECRUITING

Decatur, Georgia, 30030, United States
Adams Clinical Bronx
RECRUITING

The Bronx, New York, 10461, United States
Adams Clinical Harlem
RECRUITING

New York, New York, 10029, United States
Alpha Recherche Clinique
RECRUITING

Québec, G3K 2P8, Canada
Alzheimer's Research and Treatment Center - Columbus
RECRUITING

Columbus, Georgia, 31904, United States
Alzheimer?s Research and Treatment Center
RECRUITING

Wellington, Florida, 33414, United States
Anhui Provincial Hospital
ACTIVE_NOT_RECRUITING

Hefei, 230088, China
Asst Degli Spedali Civili Di Brescia
RECRUITING

Brescia, Lombardy, 25123, Italy
Axiom Brain Health LLC
RECRUITING

Tampa, Florida, 33609, United States
Azienda Ospedaliero Universitaria San Martino
RECRUITING

Genoa, Liguria, 16132, Italy
Banner Sun Health Research Institute
RECRUITING

Sun City, Arizona, 85351, United States
Basil Clinical
RECRUITING

Laurelton, New York, 11413-2016, United States
Baycrest Academy for Research and Education
RECRUITING

North YORK, Ontario, M6A 2E1, Canada
Beijing Friendship Hospital Affiliated of Capital University of Medical Science
RECRUITING

Beijing, 100050, China
Beijing Tiantan Hospital,Capital Medical University
RECRUITING

Beijing, 100050, China
Boston Center for Memory
RECRUITING

Newton, Massachusetts, 02459, United States
Brigham and Womens Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Butler Hospital
RECRUITING

Providence, Rhode Island, 02906, United States
CHRU - Hôpital Bretonneau
ACTIVE_NOT_RECRUITING

Tours, 37000, France
CHU Rennes - Hopital Pontchaillou
ACTIVE_NOT_RECRUITING

Rennes, 35033, France
Campus for Ageing & Vitality
RECRUITING

Newcastle, NE4 5PL, United Kingdom
Centricity East York
RECRUITING

Toronto, Ontario, M4G 3E8, Canada
Centro de Pesquisas Clinicas - CPCLIN
RECRUITING

São Paulo, São Paulo, 01228-200, Brazil
Centrum Leczenia Zaburzen Pamieci
ACTIVE_NOT_RECRUITING

Warsaw, 03-839, Poland
Centrum Medyczne Neuromed Sp. z.o.o.
ACTIVE_NOT_RECRUITING

Bydgoszcz, 85-163, Poland
Chang Gung Medical Foundation Linkou Branch
RECRUITING

Taoyuan City, 333, Taiwan
Charing Cross Hospital
RECRUITING

London, W6 8RF, United Kingdom
Charter Research - Lady Lake/The Villages
RECRUITING

The Villages, Florida, 32162, United States
China Medical University Hospital
RECRUITING

North Dist., 40447, Taiwan
Clinique Memoire de Montreal
RECRUITING

Montreal, Quebec, H2X 3B9, Canada
Conquest Research, LLC
RECRUITING

Winter Park, Florida, 32789, United States
Department of Old Age Psychiatry Kings College
RECRUITING

London, SE5 8AF, United Kingdom
ETG Neuroscience Sp. z o.o.
ACTIVE_NOT_RECRUITING

Warsaw, 02-677, Poland
Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital
RECRUITING

Tokyo, 190-8531, Japan
Fondazione Santa Lucia IRCCS
RECRUITING

Rome, Lazio, 00179, Italy
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, 350001, China
Gemeinschaftspraxis Dr. Wolfram von Pannwitz, MBA & Dr. med. Marie Perle Brinckmann
ACTIVE_NOT_RECRUITING

Steglitz, 12163, Germany
Genesis Neuroscience Clinic
RECRUITING

Knoxville, Tennessee, 37909, United States
Gerontopole
ACTIVE_NOT_RECRUITING

Toulouse, 31059, France
Gesundheit Nord, Klinikum Bremen-Ost
ACTIVE_NOT_RECRUITING

Bremen, 28325, Germany
Guangdong General Hospital
RECRUITING

Guangzhou, 510030, China
Hawaii Pacific Neuroscience
RECRUITING

Honolulu, Hawaii, 96817, United States
Hopital B Roger Salengro
ACTIVE_NOT_RECRUITING

Lille, 59037, France
Hopital Lariboisiere
ACTIVE_NOT_RECRUITING

Paris, 75475, France
Hopital des Charpennes
ACTIVE_NOT_RECRUITING

Villeurbanne, 69100, France
Hospital General De Catalunya
RECRUITING

Sant Cugat del Vallès, Barcelona, 8195, Spain
Hospital Italiano
RECRUITING

CABA, C1199ABA, Argentina
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
Hospital Mutua De Terrasa
RECRUITING

Terrassa, Barcelona, 08222, Spain
Hospital Quiron de Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Dr. Peset
RECRUITING

Valencia, 46017, Spain
Hospital Universitario Reina Sofia
RECRUITING

Córdoba, 14004, Spain
Hospital Universitario de Santa Maria
RECRUITING

Lleida, Lerida, 25198, Spain
Hospital Universitario de la Princesa
RECRUITING

Madrid, 28006, Spain
Hospital Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital das Clinicas - UFMG
RECRUITING

Belo Horizonte, Minas Gerais, 31270-901, Brazil
Huashan Hospital, Fudan University
RECRUITING

Shanghai, 200040, China
Hôpital Broca
ACTIVE_NOT_RECRUITING

Le Kremlin Bicétre Cedex, 94275, France
Hôpital de Brabois
ACTIVE_NOT_RECRUITING

Vandœuvre-lès-Nancy, 54500, France
Hôpital de la Timone
ACTIVE_NOT_RECRUITING

Marseille, 13385, France
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.
ACTIVE_NOT_RECRUITING

Lublin, 20-410, Poland
Inglewood Clinicals
RECRUITING

Los Angeles, California, 90056, United States
Irvine Center for Clinical Research
RECRUITING

Irvine, California, 92614, United States
K2 Medical Research - Nashville
RECRUITING

Nashville, Tennessee, 37204, United States
K2 Medical Research - The Villages
RECRUITING

Lady Lake, Florida, 32159, United States
K2 Medical Research, LLC
RECRUITING

Maitland, Florida, 32751, United States
Kaohsiung Medical University Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Keio University Hospital
RECRUITING

Tokyo, 160-8582, Japan
Kerwin Research Center, LLC
RECRUITING

Dallas, Texas, 75231, United States
Klinikum Bayreuth Standort Hohe Warte Klinik fur Neurologie
ACTIVE_NOT_RECRUITING

Bayreuth, 95445, Germany
Klinikum rechts der Isar der TU München
ACTIVE_NOT_RECRUITING

München, 81675, Germany
Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K
ACTIVE_NOT_RECRUITING

Krakow, 31-505, Poland
Krankenhaus der Barmherzigen Brüder Trier
ACTIVE_NOT_RECRUITING

Trier, 54292, Germany
Kyoto University Hospital
RECRUITING

Kyoto, 606-8507, Japan
Lynfield Mount hospital
RECRUITING

Bradford, BD9 6DP, United Kingdom
MVZ Rheumatologie und Autoimummedizin Hamburg GmbH
ACTIVE_NOT_RECRUITING

Hamburg, 20095, Germany
Memory Clinic Ochanomizu
RECRUITING

Tokyo, 113-0034, Japan
Mie University Hospital
RECRUITING

Mie, 514-8507, Japan
Mishuku Hospital
RECRUITING

Meguro-Ku, 153-0051, Japan
NEURO-CARE Sp. z o.o. Sp. Komandytowa
ACTIVE_NOT_RECRUITING

Katowice, 40-749, Poland
NZOZ WCA
ACTIVE_NOT_RECRUITING

Wroc?aw, 53-659, Poland
Nanjing Brain Hospital
RECRUITING

Nanjing, 210029, China
Nanjing First Hospital
ACTIVE_NOT_RECRUITING

Nanjing, 210029, China
National Center of Neurology and Psychiatry
RECRUITING

Tokyo, 187-8551, Japan
National Clinical Research Inc.-Richmond
RECRUITING

Richmond, Virginia, 23294, United States
National Hospital Organization Utano National Hospital
RECRUITING

Kyoto, 616-8255, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
NeuroCentrum Odenwald
ACTIVE_NOT_RECRUITING

Erbach/Odenwald, 64711, Germany
Neurology UKSH Campus Kiel
ACTIVE_NOT_RECRUITING

Kiel, 24105, Germany
Nmedis sp. z o.o.
RECRUITING

Rzeszów, 35-323, Poland
Ohio State University
RECRUITING

Columbus, Ohio, 43221, United States
P-One Clinic
RECRUITING

Tokyo, 192-0071, Japan
Peking University First Hospital
RECRUITING

Beijing, 100034, China
Peking University Sixth Hospital
RECRUITING

Beijing, 100083, China
Policlínica Guipuzcoa
RECRUITING

Donostia / San Sebastian, Guipuzcoa, 20014, Spain
RE:Cognition (Chicago)
RECRUITING

Chicago, Illinois, 60611, United States
RE:Cognition Health
RECRUITING

London, W1G 8TA, United Kingdom
Re:Cognition Health - Houston
RECRUITING

Houston, Texas, 77030, United States
Recognition Health Bristol
RECRUITING

Bristol, BS32 4SY, United Kingdom
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200127, China
Renstar Medical Research
RECRUITING

Ocala, Florida, 34470, United States
Richmond Clinical Trials
RECRUITING

Richmond, British Columbia, V6V 2L1, Canada
Ruijin Hospital Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, 200025, China
SPSK nr 1
ACTIVE_NOT_RECRUITING

Zabrze, 41-800, Poland
Sanatorio del Sur S.A.
RECRUITING

San Miguel de Tucumán, T4000IDK, Argentina
Shanghai First People's Hospital
RECRUITING

Shanghai, 200080, China
Shanghai Pudong Hospital
RECRUITING

Shanghai, 201399, China
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, 200233, China
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
RECRUITING

Hangzhou, 310016, China
South Texas Research Institute - Edinburg
RECRUITING

Edinburg, Texas, 78539, United States
St. Josef-Hospital, Klinik für Neurologie
ACTIVE_NOT_RECRUITING

Bochum, 44791, Germany
Surrey and Borders NHS Foundation Trust
RECRUITING

Chertsey, KT16 9AU, United Kingdom
Syrentis Clinical Research
RECRUITING

Santa Ana, California, 92705, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Medical University ?Shuang Ho Hospital
RECRUITING

New Taipei City, 23561, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tandem Clinical Research, LLC
RECRUITING

Marrero, Louisiana, 70072, United States
Tees,Esk and Wear Valleys NHS Foundation Trust
RECRUITING

York, YO31 8TA, United Kingdom
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, Jiangsu, 221002, China
The Cognitive and Research Center of New Jersey
RECRUITING

Ridgewood, New Jersey, 07450, United States
The First Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, 230022, China
The First Affiliated Hospital, Chongqing Medical University
RECRUITING

Chongqing, 400016, China
The First Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The Second Affiliated Hospital of Soochow University
RECRUITING

Suzhou, 215004, China
The second Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, 510260, China
Tianjin Medical University General Hospital
RECRUITING

Tianjin, 300052, China
Tokyo Metropolitan Institute for Geriatrics and Gerontology
RECRUITING

Tokyo, 173-0015, Japan
Toronto Memory Program
RECRUITING

Toronto, Ontario, M3B 2S7, Canada
Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5T 2S8, Canada
Triad Clinical Trials
RECRUITING

Greensboro, North Carolina, 27410, United States
UCSF - Memory and Aging Center
RECRUITING

San Francisco, California, 94158, United States
Umberto I Policlinico di Roma-Università di Roma La Sapienza
RECRUITING

Rome, Lazio, 00185, Italy
Uniklinik RWTH Aachen
ACTIVE_NOT_RECRUITING

Aachen, 52074, Germany
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie
ACTIVE_NOT_RECRUITING

Freiburg im Breisgau, 79106, Germany
Universitätsklinikum Ulm
ACTIVE_NOT_RECRUITING

Ulm, 89081, Germany
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medical College
RECRUITING

New York, New York, 10021, United States
West China Hospital - Sichuan University
RECRUITING

Chengdu, 610047, China
Yamagata Tokusyukai Hospital
RECRUITING

Yamagata, 990-0834, Japan
Zentrum für klinische Forschung Dr. med. Irma Schöll
ACTIVE_NOT_RECRUITING

Bad Homburg, 61348, Germany
Zhongda Hospital Affiliated to Southeast University
ACTIVE_NOT_RECRUITING

Nanjing, 210009, China

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