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PET scans reveal hidden brain inflammation in rare movement disorder

NCT ID NCT07000851

Recruiting now Knowledge-focused Sponsor: Jennifer Whitwell Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study uses advanced PET scans and blood tests to examine brain inflammation and white matter damage in people with corticobasal syndrome, a rare movement and thinking disorder. Researchers will compare these brain changes across different subtypes of the condition and against healthy volunteers. The goal is to better understand the underlying disease processes, which could guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
C-11 ER176 Radiotracer, C-11 PiB, AV1451 Tau (diagnostic PET tracers)
What this could lead to
If successful, this study could reveal how inflammation and white matter damage contribute to corticobasal syndrome, potentially pointing toward new treatment targets.
What could go wrong
This is an observational imaging study, not a treatment trial. It may not directly lead to therapies, and findings may not apply to all patients with the condition.

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Conditions

The condition(s) this trial relates to.

Color Vision Defects Corticobasal Degeneration corticobasal degeneration disorder corticobasal syndrome Nerve Degeneration neurodegenerative disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORTICO BASAL DEGENERATION CORTICOBASAL DEGENERATION CORTICOBASAL DEGENERATION (CBD) CORTICOBASAL SYNDROME CORTICOBASAL SYNDROME (CBS)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

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