Light and magnets: a new weapon against Alzheimer's?

NCT ID NCT05926011

Recruiting now Disease control Sponsor: REGEnLIFE SAS Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation along the brain-gut axis. About 108 participants will be randomly assigned to receive the active device or an inactive sham version, with cognitive changes measured over 26 weeks. If successful, this non-invasive approach could offer a new way to manage Alzheimer's symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RGn600, a non-invasive helmet and abdominal belt device combining photobiomodulation (red to near-infrared light) and static magnetic stimulation
What this could lead to: If effective, this device could offer a drug-free way to slow cognitive decline in Alzheimer's disease, potentially improving quality of life for patients and families.
What could go wrong: This is a pivotal trial, but the device's benefit is unproven. It may not outperform the sham, and effects could be modest or temporary. The mechanism—reducing brain-gut inflammation—is still theoretical.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease brain disorder central nervous system disorder nervous system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

Locations

Biofortis
RECRUITING

Saint-Herblain, 44800, France
CH Lavaur
RECRUITING

Lavaur, 81500, France
CHIC Castres Mazamet Site Autan
RECRUITING

Castres, 81100, France
Hôpital Broca
RECRUITING

Paris, 75013, France
Hôpital Lariboisière
RECRUITING

Paris, 75010, France
Hôpital des Charpennes - HCL
RECRUITING

Villeurbanne, 69100, France
Toulouse University Hospital Gerontopole
RECRUITING

Toulouse, 31 000, France

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