Hope for Alzheimer's psychosis: new drug aims to stop relapses

NCT ID NCT05511363

Recruiting now Disease control Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study tests an investigational drug called KarXT to see if it can prevent the return of psychosis (like hallucinations or delusions) in people with Alzheimer's disease. About 410 participants aged 55-90 will receive either KarXT or a placebo for 38 weeks. The main goal is to see if KarXT delays or prevents a relapse compared to placebo.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSYCHOSIS ASSOCIATED WITH ALZHEIMER'S DISEASE

Contacts and locations

Locations

A-SHINE s.r.o.
RECRUITING

Pilsen, 301 00, Czechia
ATP Clinical Research-302 W La Veta Ave
RECRUITING

Orange, California, 92866, United States
Arrow Clinical Trials
RECRUITING

Daytona Beach, Florida, 32117-5532, United States
Azienda Ospedaliero-Universitaria di Modena - Policlinico di Modena
RECRUITING

Baggiovara, Modena, 41126, Italy
CLINTRIAL s.r.o.
RECRUITING

Prague, Praha, Hlavní Mesto, 100 00, Czechia
Clinical Centre of Vojvodina
RECRUITING

Novi Sad, 21000, Serbia
Clinical Hospital Center Dragisa Misovic Dedinje
RECRUITING

Belgrade, 11000, Serbia
Clinical Trial Network - 7080 Southwest Fwy
RECRUITING

Houston, Texas, 77074-2085, United States
Complejo Asistencial Universitario de Salamanca - H. Clinico
RECRUITING

Salamanca, 37007, Spain
Crystal Comfort, s.r.o.
RECRUITING

Vranov nad Topľou, 093 01, Slovakia
EPAMED s.r.o
RECRUITING

Košice, 040 01, Slovakia
Five Towns Neurology, PC
RECRUITING

Woodmere, New York, 11598-1739, United States
Hospital Provincial de Zamora
RECRUITING

Zamora, 49021, Spain
Hospital Universitario Rio Hortega
RECRUITING

Valladolid, 47012, Spain
Hospital Viamed Montecanal
RECRUITING

Zaragoza, 50012, Spain
Hospital Victoria Eugenia
RECRUITING

Seville, 41009, Spain
K2 Medical Research - Maitland
RECRUITING

Maitland, Florida, 32751-5669, United States
K2 Medical Research - Winter Garden
RECRUITING

Clermont, Florida, 34711-5933, United States
KONZILIUM s.r.o
RECRUITING

Dubnica nad Váhom, 018 41, Slovakia
Local Institution - 1-14IBHZ4D
NOT_YET_RECRUITING

Stara Zagora, 6003, Bulgaria
Local Institution - 1-14IG4A1R
NOT_YET_RECRUITING

Seoul, Seoul Teugbyeolsi, 05505, South Korea
Local Institution - 1-14IG4A3I
NOT_YET_RECRUITING

Pusan, Busan Gwangyeogsi, 49241, South Korea
Local Institution - 1-14IL3BFV
NOT_YET_RECRUITING

Prague, 109 00, Czechia
Local Institution - 1-14IL3BJP
NOT_YET_RECRUITING

New York, New York, 10003-1759, United States
Local Institution - 1-14IL3BK3
NOT_YET_RECRUITING

Ahmedabad, Gujarat, 380061, India
Local Institution - 1-14ILFYZQ
NOT_YET_RECRUITING

Salerno, Campania, 84131, Italy
Local Institution - 1-14ILFZ33
NOT_YET_RECRUITING

Villeurbanne, Rhône, 69100, France
Local Institution - 1-14IVVWPL
NOT_YET_RECRUITING

Junggu, Incheon Gwang'yeogsi, 22332, South Korea
Local Institution - 1-14IW4MT8
NOT_YET_RECRUITING

Hyderabad, 500034, India
Local Institution - 1-14IW4MUN
NOT_YET_RECRUITING

New Delhi, National Capital Territory of Delhi, 110029, India
Local Institution - 1-14JRHMIY
NOT_YET_RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
Local Institution - 1002
ACTIVE_NOT_RECRUITING

Staten Island, New York, 10314-1607, United States
Local Institution - 1003
WITHDRAWN

Canton, Ohio, 44718, United States
Local Institution - 1005
COMPLETED

Miami, Florida, 33125-3724, United States
Local Institution - 1006
ACTIVE_NOT_RECRUITING

Miami, Florida, 33173-1474, United States
Local Institution - 1008
ACTIVE_NOT_RECRUITING

St. Petersburg, Florida, 33713-8844, United States
Local Institution - 1009
ACTIVE_NOT_RECRUITING

Miami, Florida, 33155-4630, United States
Local Institution - 1010
COMPLETED

Miami, Florida, 33137, United States
Local Institution - 1011
COMPLETED

Boca Raton, Florida, 33487-2768, United States
Local Institution - 1012
COMPLETED

Pensacola, Florida, 32504-8608, United States
Local Institution - 1013
COMPLETED

Stamford, Connecticut, 06905-1206, United States
Local Institution - 1014
COMPLETED

Colorado Springs, Colorado, 80907-5302, United States
Local Institution - 1015
COMPLETED

Bradenton, Florida, 34209-4687, United States
Local Institution - 1016
COMPLETED

Oklahoma City, Oklahoma, 73112, United States
Local Institution - 1017
COMPLETED

New York, New York, 10032, United States
Local Institution - 1018
ACTIVE_NOT_RECRUITING

Manhasset, New York, 11030-3816, United States
Local Institution - 1019
COMPLETED

Allentown, Pennsylvania, 18103, United States
Local Institution - 1020
COMPLETED

Bonita Springs, Florida, 34134, United States
Local Institution - 1021
ACTIVE_NOT_RECRUITING

Miami, Florida, 33122-1335, United States
Local Institution - 1022
COMPLETED

Flower Mound, Texas, 75028-2011, United States
Local Institution - 1024
WITHDRAWN

Hialeah, Florida, 33012-5884, United States
Local Institution - 1026
ACTIVE_NOT_RECRUITING

Miami Springs, Florida, 33166-5260, United States
Local Institution - 1027
WITHDRAWN

Ocala, Florida, 34470-6657, United States
Local Institution - 1028
WITHDRAWN

Oklahoma City, Oklahoma, 73104-5007, United States
Local Institution - 1029
ACTIVE_NOT_RECRUITING

Homewood, Alabama, 35209-6809, United States
Local Institution - 1030
WITHDRAWN

New York, New York, 10016, United States
Local Institution - 1031
WITHDRAWN

Irvine, California, 92612-1246, United States
Local Institution - 1032
ACTIVE_NOT_RECRUITING

Miami Lakes, Florida, 33014-5602, United States
Local Institution - 1033
COMPLETED

Encino, California, 91436-2201, United States
Local Institution - 1034
COMPLETED

Stony Brook, New York, 11794-0001, United States
Local Institution - 1035
COMPLETED

Charleston, South Carolina, 29425-8900, United States
Local Institution - 1036
COMPLETED

Frisco, Texas, 75034-6262, United States
Local Institution - 1037
COMPLETED

Chicago, Illinois, 60623, United States
Local Institution - 1038
COMPLETED

Franklin, Tennessee, 37067-5922, United States
Local Institution - 1040
WITHDRAWN

The Villages, Florida, 32159-8986, United States
Local Institution - 1041
COMPLETED

Tampa, Florida, 33607-4629, United States
Local Institution - 1042
ACTIVE_NOT_RECRUITING

Miami, Florida, 33186-5882, United States
Local Institution - 1043
COMPLETED

Pasadena, California, 91106, United States
Local Institution - 1044
COMPLETED

Phoenix, Arizona, 85012-2836, United States
Local Institution - 1045
ACTIVE_NOT_RECRUITING

Doral, Florida, 33172-2638, United States
Local Institution - 1046
ACTIVE_NOT_RECRUITING

Hialeah, Florida, 33012-5826, United States
Local Institution - 1047
COMPLETED

San Marcos, California, 92069-3595, United States
Local Institution - 1049
ACTIVE_NOT_RECRUITING

Homestead, Florida, 33032, United States
Local Institution - 1051
COMPLETED

New York, New York, 10032-3720, United States
Local Institution - 1052
ACTIVE_NOT_RECRUITING

Hialeah, Florida, 33012, United States
Local Institution - 1053
ACTIVE_NOT_RECRUITING

Miami, Florida, 33166, United States
Local Institution - 1054
ACTIVE_NOT_RECRUITING

Miami, Florida, 33186-4643, United States
Local Institution - 1111
ACTIVE_NOT_RECRUITING

Miami, Florida, 33173, United States
Local Institution - 1115
ACTIVE_NOT_RECRUITING

Miami, Florida, 33135, United States
Local Institution - 1129
ACTIVE_NOT_RECRUITING

Miami, Florida, 33165-3947, United States
Local Institution - 1143
COMPLETED

Miami, Florida, 33145-2455, United States
Local Institution - 2103
WITHDRAWN

Swindon, Wiltshire, SN3 6BW, United Kingdom
Local Institution - 2104
WITHDRAWN

Motherwell, ML1 4UF, United Kingdom
Local Institution - 2105
WITHDRAWN

Aberdeen, AB25 2ZL, United Kingdom
Local Institution - 2205
COMPLETED

Barcelona, 8028, Spain
Local Institution - 2207
COMPLETED

Madrid, 28006, Spain
Local Institution - 2301
COMPLETED

Rome, Lazio, 00179, Italy
Local Institution - 2302
COMPLETED

Pisa, 56126, Italy
Local Institution - 2303
ACTIVE_NOT_RECRUITING

Roma, 00168, Italy
Local Institution - 2304
COMPLETED

Milan, 20121, Italy
Local Institution - 2305
COMPLETED

Monza, 20900, Italy
Local Institution - 2307
ACTIVE_NOT_RECRUITING

Ponderano (Biella), Piedmont, 13875, Italy
Local Institution - 2308
COMPLETED

Florence, Tuscany, 50139, Italy
Local Institution - 2309
COMPLETED

Roma, 00189, Italy
Local Institution - 2401
COMPLETED

Böblingen, Baden-Wurttemberg, 71034, Germany
Local Institution - 2402
WITHDRAWN

Homburg, Saarland, 66424, Germany
Local Institution - 2403
WITHDRAWN

Bayreuth, Bavaria, 95445, Germany
Local Institution - 2501
ACTIVE_NOT_RECRUITING

Reims, Marne, 51100, France
Local Institution - 2502
ACTIVE_NOT_RECRUITING

Dijon, 21079, France
Local Institution - 2503
COMPLETED

Rouen, 76000, France
Local Institution - 4001
COMPLETED

Kutná Hora, 284 01, Czechia
Local Institution - 4003
WITHDRAWN

Brno, South Moravian, 628 00, Czechia
Local Institution - 4004
COMPLETED

Prague, 140 00, Czechia
Local Institution - 4101
ACTIVE_NOT_RECRUITING

Zagreb, City of Zagreb, 10090, Croatia
Local Institution - 4103
COMPLETED

Zagreb, City of Zagreb, 10000, Croatia
Local Institution - 4105
ACTIVE_NOT_RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
Local Institution - 4305
COMPLETED

Kovin, 26220, Serbia
Local Institution - 4307
COMPLETED

Belgrade, 11000, Serbia
Local Institution - 4311
COMPLETED

Vršac, 26300, Serbia
Local Institution - 4404
WITHDRAWN

Žilina, 012 07, Slovakia
Local Institution - 4502
COMPLETED

Sofia, Sofia-Grad, 1510, Bulgaria
Local Institution - 4504
COMPLETED

Vratsa, 3000, Bulgaria
Local Institution - 4505
COMPLETED

Sofia, Sofia-Grad, 1431, Bulgaria
Local Institution - 4506
NOT_YET_RECRUITING

Cherven Bryag, 5980, Bulgaria
MUDr. Beata Dupejova, Neurologicka ambulancia, s.r.o.
RECRUITING

Banská Bystrica, 974 04, Slovakia
Medical Center Medconsult Pleven OOD
RECRUITING

Pleven, 5800, Bulgaria
Medical Center Sveti Naum EOOD
RECRUITING

Sofia, 1113, Bulgaria
Military Medical Academy
RECRUITING

Belgrade, 11000, Serbia
Military Medical Academy
RECRUITING

Belgrade, 11000, Serbia
Polyclinic Neuron
RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
Psychiatric Clinic Sveti Ivan
RECRUITING

Zagreb, City of Zagreb, 10090, Croatia
Sunwise Clinical Research, LLC - Walnut Creek - IVY - PPDS
RECRUITING

Walnut Creek, California, 94596, United States
University Clinical Center Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center of Serbia - Pasterova 2 - PPDS
RECRUITING

Belgrade, Belgrade, 11000, Serbia
University of South Florida
RECRUITING

Tampa, Florida, 33606, United States
Univerzitna nemocnica L Pasteura Kosice-Rastislavova 43
RECRUITING

Košice, Košice Region, 041 90, Slovakia
Vestra Clinics s.r.o.
RECRUITING

Rychnov nad Kněžnou, 516 01, Czechia

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