Hope for Alzheimer's patients: new drug targets psychosis

NCT ID NCT06126224

Recruiting now Symptom relief Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company Source: ClinicalTrials.gov ↗

First seen Mar 29, 2026 · Last updated May 16, 2026 · Updated 4 times

Summary

This study tests a drug called KarXT to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 500 participants aged 55 to 90 with mild to severe Alzheimer's and moderate to severe psychosis will receive either KarXT or a placebo. The goal is to improve symptoms like false beliefs and seeing things that aren't there.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Locations

Health Synergy Clinical Research,LLC - Stuart
RECRUITING

Stuart, Florida, 34994, United States

Contact Phone: •••-•••-••••
Local Institution - 0150
ACTIVE_NOT_RECRUITING

Homestead, Florida, 33032-8187, United States
Local Institution - 1007
ACTIVE_NOT_RECRUITING

Walnut Creek, California, 94596, United States
Local Institution - 1009
ACTIVE_NOT_RECRUITING

Miami, Florida, 33155, United States
Local Institution - 1039
ACTIVE_NOT_RECRUITING

Maitland, Florida, 32751-5669, United States
Local Institution - 1040
WITHDRAWN

The Villages, Florida, 32159-8986, United States
Local Institution - 1041
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33607-4629, United States
Local Institution - 1044
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85012-2836, United States
Local Institution - 1102
ACTIVE_NOT_RECRUITING

Miami Lakes, Florida, 33014-6435, United States
Local Institution - 1103
ACTIVE_NOT_RECRUITING

Sherman Oaks, California, 91403-2131, United States
Local Institution - 1104
ACTIVE_NOT_RECRUITING

Anaheim, California, 92805-5854, United States
Local Institution - 1105
ACTIVE_NOT_RECRUITING

Miami, Florida, 33179-2537, United States
Local Institution - 1106
RECRUITING

Cypress, Texas, 77429-6070, United States

Contact
Local Institution - 1107
ACTIVE_NOT_RECRUITING

Hialeah, Florida, 33012-3618, United States
Local Institution - 1108
ACTIVE_NOT_RECRUITING

Miami, Florida, 33133-4231, United States
Local Institution - 1109
ACTIVE_NOT_RECRUITING

Miami, Florida, 33174-2950, United States
Local Institution - 1110
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33629-5837, United States
Local Institution - 1111
ACTIVE_NOT_RECRUITING

Miami, Florida, 33126-5683, United States
Local Institution - 1112
ACTIVE_NOT_RECRUITING

Orlando, Florida, 32807-3555, United States
Local Institution - 1113
ACTIVE_NOT_RECRUITING

Miami, Florida, 33155-6630, United States
Local Institution - 1114
ACTIVE_NOT_RECRUITING

Marrero, Louisiana, 70072-3083, United States
Local Institution - 1115
ACTIVE_NOT_RECRUITING

Miami, Florida, 33135, United States
Local Institution - 1116
ACTIVE_NOT_RECRUITING

Chandler, Arizona, 85286, United States
Local Institution - 1117
ACTIVE_NOT_RECRUITING

Los Alamitos, California, 90720-6506, United States
Local Institution - 1118
ACTIVE_NOT_RECRUITING

Miami, Florida, 33122-1721, United States
Local Institution - 1119
ACTIVE_NOT_RECRUITING

Canoga Park, California, 91303-1844, United States
Local Institution - 1120
ACTIVE_NOT_RECRUITING

Hialeah, Florida, 33012-4648, United States
Local Institution - 1121
WITHDRAWN

Red Oak, Texas, 75154, United States
Local Institution - 1122
ACTIVE_NOT_RECRUITING

Dayton, Ohio, 45459-4248, United States
Local Institution - 1123
COMPLETED

Tampa, Florida, 33614-2846, United States
Local Institution - 1124
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33614-2700, United States
Local Institution - 1125
ACTIVE_NOT_RECRUITING

Miami, Florida, 33135-1601, United States
Local Institution - 1126
ACTIVE_NOT_RECRUITING

Miami Gardens, Florida, 33056-4000, United States
Local Institution - 1127
ACTIVE_NOT_RECRUITING

Largo, Florida, 33777-1359, United States
Local Institution - 1129
ACTIVE_NOT_RECRUITING

Miami, Florida, 33165-3947, United States
Local Institution - 1131
RECRUITING

Viera, Florida, 32940, United States

Contact
Local Institution - 1132
ACTIVE_NOT_RECRUITING

Flowood, Mississippi, 39232, United States
Local Institution - 1133
ACTIVE_NOT_RECRUITING

Sweetwater, Florida, 33182, United States
Local Institution - 1134
ACTIVE_NOT_RECRUITING

Stafford, Texas, 77477-3929, United States
Local Institution - 1135
WITHDRAWN

Port Jefferson Station, New York, 11776-3386, United States
Local Institution - 1136
ACTIVE_NOT_RECRUITING

Orlando, Florida, 32806-1041, United States
Local Institution - 1137
ACTIVE_NOT_RECRUITING

Port Orange, Florida, 32127-2914, United States
Local Institution - 1138
ACTIVE_NOT_RECRUITING

Cutler Bay, Florida, 33189-1230, United States
Local Institution - 1139
ACTIVE_NOT_RECRUITING

Rochester Hills, Michigan, 48307-2760, United States
Local Institution - 1140
ACTIVE_NOT_RECRUITING

Hialeah, Florida, 33016-1814, United States
Local Institution - 1141
WITHDRAWN

Columbus, Georgia, 31909-1693, United States
Local Institution - 1142
ACTIVE_NOT_RECRUITING

Lancaster, California, 93534-2839, United States
Local Institution - 1143
ACTIVE_NOT_RECRUITING

Miami, Florida, 33145-2455, United States
Local Institution - 1144
WITHDRAWN

Las Vegas, Nevada, 89106-4145, United States
Local Institution - 1145
ACTIVE_NOT_RECRUITING

Homestead, Florida, 33032-8187, United States
Local Institution - 1146
ACTIVE_NOT_RECRUITING

Maitland, Florida, 32751-6138, United States
Local Institution - 1147
ACTIVE_NOT_RECRUITING

Miami, Florida, 33176-7947, United States
Local Institution - 1148
ACTIVE_NOT_RECRUITING

Elgin, Illinois, 60123-9215, United States
Local Institution - 1149
WITHDRAWN

Malvern, Pennsylvania, 19355-3267, United States
Local Institution - 1150
ACTIVE_NOT_RECRUITING

Miami, Florida, 33165, United States
Local Institution - 1151
ACTIVE_NOT_RECRUITING

Encino, California, 91316, United States
Local Institution - 1152
WITHDRAWN

Augusta, Georgia, 30912-0020, United States
Local Institution - 1153
WITHDRAWN

New Hyde Park, New York, 11042-2062, United States
Local Institution - 1154
ACTIVE_NOT_RECRUITING

Katy, Texas, 77450-1759, United States
Local Institution - 1155
ACTIVE_NOT_RECRUITING

Hialeah, Florida, 33012-3158, United States
Local Institution - 1156
ACTIVE_NOT_RECRUITING

Clermont, Florida, 34711-5190, United States
Local Institution - 1157
ACTIVE_NOT_RECRUITING

Miami, Florida, 33184-1412, United States
Local Institution - 1158
ACTIVE_NOT_RECRUITING

Miami, Florida, 33175, United States
Local Institution - 1159
ACTIVE_NOT_RECRUITING

Miami, Florida, 33032, United States
Local Institution - 1160
WITHDRAWN

Apopka, Florida, 32703-5835, United States
Local Institution - 1161
ACTIVE_NOT_RECRUITING

Decatur, Georgia, 30030, United States
Local Institution - 1162
ACTIVE_NOT_RECRUITING

Delray Beach, Florida, 33445-2581, United States
Local Institution - 1163
ACTIVE_NOT_RECRUITING

Houston, Texas, 77074-2085, United States
Local Institution - 1164
ACTIVE_NOT_RECRUITING

Doral, Florida, 33122-1620, United States
Local Institution - 1165
ACTIVE_NOT_RECRUITING

Fort Myers, Florida, 33912-4302, United States
Local Institution - 1501
ACTIVE_NOT_RECRUITING

Culiacán, Sinaloa, 80020, Mexico
Local Institution - 1502
ACTIVE_NOT_RECRUITING

Saltillo Centro, Coahuila, 25000, Mexico
Local Institution - 1503
ACTIVE_NOT_RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Local Institution - 1504
WITHDRAWN

Zona Urbana Río Tijuana, Estado de Baja California, 22010, Mexico
Local Institution - 1505
ACTIVE_NOT_RECRUITING

Monterrey, Nuevo León, 64620, Mexico
Local Institution - 1506
ACTIVE_NOT_RECRUITING

México, 03100, Mexico
Local Institution - 1507
WITHDRAWN

Zapopan, Jalisco, 45170, Mexico
Local Institution - 1601
WITHDRAWN

Verdun, Quebec, H4H 1R3, Canada
Local Institution - 1602
WITHDRAWN

Toronto, Ontario, M5B 1W8, Canada
Local Institution - 1603
WITHDRAWN

Hamilton, Ontario, ON L8M 1W9, Canada
Local Institution - 1604
WITHDRAWN

Whitby, Ontario, L1N 5S9, Canada
Local Institution - 1605
WITHDRAWN

Calgary, Alberta, T2N 1N4, Canada
Local Institution - 1606
WITHDRAWN

Montreal, Quebec, H4H 1R3, Canada
Local Institution - 2101
WITHDRAWN

London, Surrey, SE5 8AZ, United Kingdom
Local Institution - 2104
WITHDRAWN

Motherwell, ML1 4UF, United Kingdom
Local Institution - 2105
WITHDRAWN

Aberdeen, AB25 2ZL, United Kingdom
Local Institution - 2106
WITHDRAWN

Leeds, LS7 3JX, United Kingdom
Local Institution - 2107
WITHDRAWN

Sheffield, SouthYorkshire, s5 7JT, United Kingdom
Local Institution - 2108
WITHDRAWN

Swinton, Greater Manchester, M27 8FF, United Kingdom
Local Institution - 2109
WITHDRAWN

Chertsey, KT16 9AU, United Kingdom
Local Institution - 2110
WITHDRAWN

Ilford, Greater London, IG1 4HP, United Kingdom
Local Institution - 2111
WITHDRAWN

Preston, PR2 9HT, United Kingdom
Local Institution - 2112
WITHDRAWN

Edinburgh, EH4 2XU, United Kingdom
Local Institution - 2801
ACTIVE_NOT_RECRUITING

Hasselt, Limburg, 3500, Belgium
Local Institution - 2802
ACTIVE_NOT_RECRUITING

Leuven, Vlaams Brabant, 3000, Belgium
Local Institution - 2803
ACTIVE_NOT_RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium
Local Institution - 2901
WITHDRAWN

Geneva, Genève (fr), CH-1205, Switzerland
Local Institution - 2902
WITHDRAWN

Lausanne, Vaud (fr), 1011, Switzerland
Local Institution - 4201
ACTIVE_NOT_RECRUITING

Ścinawa, 59-330, Poland
Local Institution - 4202
ACTIVE_NOT_RECRUITING

Lodz, 90-227, Poland
Local Institution - 4203
WITHDRAWN

Sopot, Pomeranian Voivodeship, 81-855, Poland
Local Institution - 4204
ACTIVE_NOT_RECRUITING

Bydgoszcz, 85-080, Poland
Local Institution - 4205
ACTIVE_NOT_RECRUITING

Katowice, 40-282, Poland
Local Institution - 4206
ACTIVE_NOT_RECRUITING

Lublin, Lublin Voivodeship, 20-064, Poland
Local Institution - 4207
ACTIVE_NOT_RECRUITING

Lodz, Lódzkie, 90-349, Poland
Local Institution - 4208
ACTIVE_NOT_RECRUITING

Katowice, Silesian Voivodeship, 40-156, Poland
Local Institution - 4209
WITHDRAWN

Siemianowice Śląskie, 41-100, Poland
Local Institution - 4601
ACTIVE_NOT_RECRUITING

Pécs, Baranya, 7633, Hungary
Local Institution - 4602
ACTIVE_NOT_RECRUITING

Budapest, 1083, Hungary
Local Institution - 4603
ACTIVE_NOT_RECRUITING

Miskolc, 3526, Hungary
Local Institution - 4701
ACTIVE_NOT_RECRUITING

Eskişehir, 26040, Turkey (Türkiye)
Local Institution - 4702
ACTIVE_NOT_RECRUITING

Atakum, Samsun, 55270, Turkey (Türkiye)
Local Institution - 4703
ACTIVE_NOT_RECRUITING

Izmir, 35575, Turkey (Türkiye)
Local Institution - 4704
ACTIVE_NOT_RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Local Institution - 4705
ACTIVE_NOT_RECRUITING

Izmir, 35210, Turkey (Türkiye)
Local Institution - 4801
ACTIVE_NOT_RECRUITING

Heraklion, 71110, Greece
Local Institution - 4802
ACTIVE_NOT_RECRUITING

Chaidari, Athens, Attica, 124 62, Greece
Local Institution - 4803
ACTIVE_NOT_RECRUITING

Athens, Attica, 115 26, Greece
Local Institution - 4805
ACTIVE_NOT_RECRUITING

Athens, Attica, 115 21, Greece
Local Institution - 4806
ACTIVE_NOT_RECRUITING

Marousi, Attica, 151 23, Greece
Local Institution - 6001
RECRUITING

Las Condes, 7550000, Chile

Contact
Local Institution - 6002
RECRUITING

Providencia, Santiago Metropolitan, 7500000, Chile

Contact
Local Institution - 6003
RECRUITING

Antofagasta, 127-0244, Chile

Contact
Local Institution - 6101
WITHDRAWN

Callao, Callao 2, Peru
Local Institution - 6102
WITHDRAWN

Miraflores, Lima region, 15046, Peru
Local Institution - 6103
ACTIVE_NOT_RECRUITING

Pueblo Libre, Lima region, 15084, Peru
Local Institution - 7001
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200030, China
Local Institution - 7002
ACTIVE_NOT_RECRUITING

Chengdu, Sichuan, 610000, China
Local Institution - 7003
ACTIVE_NOT_RECRUITING

Shenzhen, Guangdong, 518118, China
Local Institution - 7004
COMPLETED

Beijing, Beijing Municipality, 100025, China
Local Institution - 7005
ACTIVE_NOT_RECRUITING

Beijing, Beijing Municipality, 100088, China
Local Institution - 7006
ACTIVE_NOT_RECRUITING

Hangzhou, Zhejiang, 310014, China
Local Institution - 7007
ACTIVE_NOT_RECRUITING

Hefei, Anhui, 230022, China
Local Institution - 7008
ACTIVE_NOT_RECRUITING

Guangzhou, Guangdong, 0, China
Local Institution - 7009
ACTIVE_NOT_RECRUITING

Guangzhou, Guangdong, 510260, China
Local Institution - 7010
ACTIVE_NOT_RECRUITING

Hangzhou, Zhejiang, 310013, China
Local Institution - 7011
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200080, China
Local Institution - 7012
ACTIVE_NOT_RECRUITING

Nanchang, Jiangxi, 330008, China
Local Institution - 7013
ACTIVE_NOT_RECRUITING

Nanjing, Jiangsu, 210011, China
Local Institution - 7014
WITHDRAWN

Nanjing, Jiangsu, 210009, China
Local Institution - 7015
ACTIVE_NOT_RECRUITING

Chongqing, Chongqing Municipality, 400016, China
Local Institution - 7016
ACTIVE_NOT_RECRUITING

Guangzhou, Guangdong, 510120, China
Local Institution - 7017
ACTIVE_NOT_RECRUITING

Hangzhou, Zhejiang, 310003, China
Local Institution - 7018
ACTIVE_NOT_RECRUITING

Wenzhou, Zhejiang, 325000, China
Local Institution - 7019
COMPLETED

Tianjin, Tianjin Municipality, 300222, China
Local Institution - 7020
ACTIVE_NOT_RECRUITING

Hangzhou, Zhejiang, 310016, China
Local Institution - 7201
ACTIVE_NOT_RECRUITING

Seoul, 143-729, South Korea
Local Institution - 7202
ACTIVE_NOT_RECRUITING

Seongnam-si, 0, South Korea
Local Institution - 7203
ACTIVE_NOT_RECRUITING

Seoul, 07071, South Korea
Local Institution - 7204
WITHDRAWN

Busan, 49201, South Korea
Local Institution - 7205
ACTIVE_NOT_RECRUITING

Incheon, Incheon Gwang'yeogsi, 21565, South Korea
Local Institution - 7206
ACTIVE_NOT_RECRUITING

Seoul, 03080, South Korea
Local Institution - 7207
ACTIVE_NOT_RECRUITING

Seongnam-si, Gyeonggido, 13496, South Korea
Local Institution - 7208
ACTIVE_NOT_RECRUITING

Buk-gu, Daegu Gwang'yeogsi, 41404, South Korea

Conditions

Explore the condition pages connected to this study.

PSYCHOSIS ASSOCIATED WITH ALZHEIMER'S DISEASE