New pill aims to quiet Alzheimer's psychosis

NCT ID NCT06887192

Recruiting now Symptom relief Sponsor: MapLight Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This Phase 2 study tests an experimental drug, ML-007C-MA, to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 300 participants aged 55 to 90 will receive either the drug or a placebo. The main goal is to measure changes in psychotic symptoms using a standard clinician rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ML-007C-MA (a combination drug taken as a tablet)
What this could lead to: If it works, this could offer a new option to reduce troubling hallucinations and delusions in people with Alzheimer's disease, improving their quality of life.
What could go wrong: This is an early Phase 2 trial with only 300 participants, so results may not confirm benefit. The drug may cause side effects or work no better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease brain disorder central nervous system disorder cognitive disorder Delusions dementia Hallucinations nervous system disorder neurodegenerative disease psychiatric disorder Psychotic Disorders Schizophrenia Spectrum and Other Psychotic Disorders tauopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSYCHOSIS ASSOCIATED WITH ALZHEIMER'S DISEASE

Contacts and locations

Locations

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Phoenix, Arizona, 85004, United States
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Scottsdale, Arizona, 85253, United States
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Tucson, Arizona, 85704, United States
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Anaheim, California, 92805, United States
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Murrieta, California, 92562, United States
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Orange, California, 92866, United States
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San Diego, California, 92123, United States
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Denver, Colorado, 80218, United States
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Boca Raton, Florida, 33428, United States
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Deerfield Beach, Florida, 33442, United States
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Doral, Florida, 33122, United States
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Homestead, Florida, 33033, United States
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Miami, Florida, 33122, United States
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Miami, Florida, 33155, United States
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Miami, Florida, 33173, United States
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Miami, Florida, 33186, United States
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Miami Gardens, Florida, 33014, United States
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Miami Gardens, Florida, 33104, United States
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Naples, Florida, 34105, United States
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Orlando, Florida, 32807, United States
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Tampa, Florida, 33629, United States
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West Palm Beach, Florida, 33407, United States
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Augusta, Georgia, 30912, United States
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Snellville, Georgia, 30078, United States
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Las Vegas, Nevada, 89121, United States
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West Long Branch, New Jersey, 07764, United States
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Dayton, Ohio, 45459, United States
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Independence, Ohio, 44131, United States
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McKinney, Texas, 75071, United States
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Sugarland, Texas, 77478, United States
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Bellevue, Washington, 98007, United States
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Córdoba, Córdoba Province, X5009BIN, Argentina
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Córdoba, X5004AOA, Argentina
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Pernik, Pernik, 2304, Bulgaria
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Sofia, Sofia, 1408, Bulgaria
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NOT_YET_RECRUITING

Brampton, Ontario, L6W 2Z8, Canada
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London, Ontario, N6A 5W9, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Lévis, Quebec, G6V 0C9, Canada
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Choceň, 565 01, Czechia
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Prague, 150 00, Czechia
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Toulouse, 31059, France
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Pécs, 7623, Hungary
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Pécs, 7633, Hungary
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Roma, 00128, Italy
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Plewiska, 62-064, Poland
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Torres Vedras, Lisbon District, 2560-280, Portugal
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Bucharest, 041914, Romania
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Kragujevac, 34000, Serbia
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Vranov nad Topľou, 093 01, Slovakia
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Daegu, 41404, South Korea
Clinical Site
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Incheon, 21565, South Korea

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