Old drug, new hope: could acetazolamide ease tough schizophrenia symptoms?
NCT ID NCT04887792
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether acetazolamide, a drug currently used for altitude sickness and glaucoma, can reduce positive symptoms (like hallucinations or delusions) in people with treatment-resistant schizophrenia. Sixty adults aged 18-55 who still have significant symptoms despite trying two different antipsychotics will receive either acetazolamide or a placebo pill, added to their current medication. The main goal is to see if the drug improves symptom severity over several weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acetazolamide (Diamox)
What this could lead to
If it works, this could point toward a new add-on treatment for people with schizophrenia whose symptoms don't improve with standard antipsychotics.
What could go wrong
This is an early Phase 1/2 trial with only 60 participants, so results may not apply widely. Acetazolamide can cause side effects like tingling, nausea, or kidney issues.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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St John's Medical College Hospital
RECRUITINGBangalore, India
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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