Could this drug slow Alzheimer's brain damage?

NCT ID NCT07033494

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study tests an experimental drug called MK-2214 in 340 people with early Alzheimer's disease. The goal is to see if it can slow the buildup of a harmful protein called tau in the brain, which damages brain cells. Participants will receive either the drug or a placebo, and researchers will monitor brain scans, thinking skills, and safety over time.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY ALZHEIMER'S DISEASE

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

AMC Research, LLC ( Site 1006)
RECRUITING

Matthews, North Carolina, 28105, United States
AZ Groeninge Campus Kennedylaan ( Site 3002)
RECRUITING

Kortrijk, West-Vlaanderen, 8500, Belgium
Alexian Brothers Medical Center-Neurosciences ( Site 1017)
RECRUITING

Elk Grove Village, Illinois, 60007, United States
Alzheimer Disease Research Center (ADRC) ( Site 1000)
RECRUITING

Albany, New York, 12208, United States
Anderson Clinical Research ( Site 1024)
RECRUITING

Redlands, California, 92374, United States
Aqualane Clinical Research ( Site 1035)
RECRUITING

Naples, Florida, 34105, United States
Association of Healthcare Corporation Koukankai Koukan Clinic ( Site 9016)
RECRUITING

Kawasaki, Kanagawa, 210-0852, Japan
Austin Health ( Site 0300)
RECRUITING

Ivanhoe, Victoria, 3079, Australia
Axiom Brain Health ( Site 1029)
RECRUITING

Tampa, Florida, 33609, United States
Basil Clinical ( Site 1065)
RECRUITING

Queens, New York, 11413, United States
Boston Center for Memory ( Site 1008)
RECRUITING

Newton, Massachusetts, 02459, United States
Brain Research Center Den Bosch B.V. ( Site 5001)
RECRUITING

's-Hertogenbosch, North Brabant, 5223 LA, Netherlands
Brain Research Center Zwolle ( Site 5002)
RECRUITING

Zwolle, Overijssel, 8025 AZ, Netherlands
Brain Research Center. ( Site 5000)
RECRUITING

Amsterdam, North Holland, 1081 GN, Netherlands
CenExel iResearch, LLC ( Site 1015)
RECRUITING

Decatur, Georgia, 30030, United States
CenExel- AMRI ( Site 1018)
RECRUITING

Toms River, New Jersey, 08755, United States
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0404)
RECRUITING

Ciudad de Buenos Aires, Buenos Aires F.D., C1431FWO, Argentina
Charter Research - Lady Lake ( Site 1019)
RECRUITING

The Villages, Florida, 32162, United States
Charter Research - Orlando ( Site 1051)
RECRUITING

Orlando, Florida, 32803, United States
Chibaken Saiseikai Narashino Hospital ( Site 9000)
RECRUITING

Narashino, Chiba, 275-8580, Japan
ClinCloud LLC ( Site 1039)
RECRUITING

Melbourne, Florida, 32940, United States
Clinical Research Professionals ( Site 1004)
RECRUITING

Chesterfield, Missouri, 63005, United States
Clinique Mémoire de Montreal ( Site 2000)
RECRUITING

Montreal, Quebec, H3G 1H9, Canada
Cliniques universitaires Saint-Luc ( Site 3001)
RECRUITING

Brussels, Bruxelles-Capitale, Region de, 1200, Belgium
Conquest Research LLC ( Site 1053)
RECRUITING

Winter Park, Florida, 32789, United States
Ewha Womans University Seoul Hospital ( Site 0201)
RECRUITING

Seoul, 07804, South Korea
Flourish Research ( Site 1048)
RECRUITING

Plymouth Meeting, Pennsylvania, 19462, United States
Fundació ACE ( Site 6003)
RECRUITING

Barcelona, Catalonia, 08028, Spain
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) ( Site 0400)
RECRUITING

Caba, C1428AQK, Argentina
Gadolin Research ( Site 1032)
RECRUITING

Beaumont, Texas, 77702, United States
HammondCare ( Site 0301)
RECRUITING

Malvern, Victoria, 3144, Australia
Hanyang University Hospital ( Site 0200)
RECRUITING

Seoul, 04763, South Korea
Hatsuta Neurology Clinic ( Site 9017)
RECRUITING

Hirakata, Osaka, 573-1121, Japan
Healthy Brain Clinic ( Site 1005)
RECRUITING

Long Beach, California, 90804, United States
Horizon Clinical Research Center - Houston ( Site 1026)
RECRUITING

Cypress, Texas, 77429, United States
Hospital Clinic i Provincial ( Site 6002)
RECRUITING

Barcelona, 08036, Spain
Hospital Universitari Mutua Terrassa ( Site 6004)
RECRUITING

Terrassa, Barcelona, 08222, Spain
Hospital del Mar ( Site 6001)
RECRUITING

Barcelona, 08003, Spain
Inage Neurology and Memory Clinic ( Site 9001)
RECRUITING

Chiba, 263-0043, Japan
Indago Research and Health Center Inc ( Site 1044)
RECRUITING

Miami Lakes, Florida, 33016, United States
Inglewood Clinical ( Site 1062)
RECRUITING

Los Angeles, California, 90056, United States
Insight Clinical Trials ( Site 1011)
RECRUITING

Independence, Ohio, 44131, United States
Irvine Clinical Research ( Site 1041)
RECRUITING

Irvine, California, 92614, United States
JEM Research Institute ( Site 1046)
RECRUITING

Atlantis, Florida, 33462, United States
K2 Medical Research ( Site 1020)
RECRUITING

Tampa, Florida, 33634, United States
K2 Medical Research ( Site 1047)
RECRUITING

Maitland, Florida, 32750, United States
KARA Institute for Neurological Diseases ( Site 0302)
RECRUITING

Macquarie Park, New South Wales, 2113, Australia
Katayama Medical Clinic ( Site 9005)
RECRUITING

Kurashiki, Okayama-ken, 710-0813, Japan
Kyushu University Hospital ( Site 9010)
RECRUITING

Fukuoka, 812-8582, Japan
Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)
RECRUITING

London, London, City of, NW1 2PG, United Kingdom
Mid Hudson Medical Research ( Site 1050)
RECRUITING

New Windsor, New York, 12553, United States
Mie University Hospital ( Site 9011)
RECRUITING

Tsu, Mie-ken, 514-8507, Japan
Moorgreen Hospital ( Site 8004)
RECRUITING

Southampton, Hampshire, SO30 3JB, United Kingdom
National Center for Geriatrics and Gerontology ( Site 9002)
RECRUITING

Ōbu, Aichi-ken, 474-8511, Japan
National Hospital Organization Hizen Psychiatric Medical Center ( Site 9004)
RECRUITING

Kanzaki-gun, Saga-ken, 8420192, Japan
National Neuroscience Institute ( Site 0101)
RECRUITING

Singapore, Central Singapore, 308433, Singapore
Neuro-Behavioral Clinical Research ( Site 1028)
RECRUITING

North Canton, Ohio, 44720, United States
Neuropsychiatric Research Center of Southwest Florida ( Site 1003)
RECRUITING

Fort Myers, Florida, 33912, United States
Okayama City General Medical Center Okayama City Hospital ( Site 9008)
RECRUITING

Okayama, 700-8557, Japan
Organizacion Medica de Investigacion ( Site 0401)
RECRUITING

Ciudad de Buenos Aires, Buenos Aires F.D., C1015ABO, Argentina
Ottawa Memory Clinic ( Site 2001)
RECRUITING

Ottawa, Ontario, K1Z 1G3, Canada
Re:Cognition Health - Birmingham ( Site 8002)
RECRUITING

Birmingham, B16 8LT, United Kingdom
Remind UK ( Site 8003)
RECRUITING

Bath, Somerset, BA1 3NG, United Kingdom
Renstar Medical Research ( Site 1012)
RECRUITING

Ocala, Florida, 34471, United States
Samsung Medical Center ( Site 0202)
RECRUITING

Seoul, 06351, South Korea
Scottish Brain Sciences ( Site 8000)
RECRUITING

Edinburgh, Edinburgh, City of, EH12 5PJ, United Kingdom
Scottish Brain Sciences Aberdeen ( Site 8001)
RECRUITING

Aberdeen, Aberdeen City, AB25 2XE, United Kingdom
Southern Neurology ( Site 0306)
RECRUITING

Kogarah, New South Wales, 2217, Australia
Suncoast Clinical Research ( Site 1007)
RECRUITING

New Port Richey, Florida, 34652, United States
Sunnybrook Research Institute ( Site 2003)
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Syrentis Clinical Research ( Site 1001)
RECRUITING

Santa Ana, California, 92705, United States
Tan Tock Seng Hospital ( Site 0102)
RECRUITING

Singapore, Central Singapore, 308433, Singapore
The Cognitive and Research Center of NJ ( Site 1057)
RECRUITING

Springfield, New Jersey, 07081, United States
The Cognitive and Research Center of New Jersey - Ridgewood ( Site 1064)
RECRUITING

Ridgewood, New Jersey, 07450, United States
Tokyo Medical University Hospital ( Site 9003)
RECRUITING

Shinjuku, Tokyo, 160-0023, Japan
Toronto Western Hospital ( Site 2004)
RECRUITING

Toronto, Ontario, M5T 2S8, Canada
UCSF Memory and Aging Center ( Site 1031)
RECRUITING

San Francisco, California, 94158, United States
UZ Leuven ( Site 3000)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
Warneford Hospital ( Site 8007)
RECRUITING

Oxford, Oxfordshire, OX3 7JX, United Kingdom
Yale University, Alzheimer's Disease Research Unit ( Site 1059)
RECRUITING

New Haven, Connecticut, 06510, United States

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