Could this new drug slow Alzheimer's? major trial begins

NCT ID NCT07170150

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated Apr 28, 2026 · Updated 36 times

Summary

This study tests an experimental drug called trontinemab in 800 people with early Alzheimer's (mild memory loss to mild dementia). The goal is to see if it can slow down worsening of symptoms over 72 weeks. Participants will receive either the drug or a placebo, and researchers will track changes in memory, daily function, and safety.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A. O. U. Federico II
RECRUITING

Naples, Campania, 80131, Italy
AD-CARE, University of Rochester Medical Center
RECRUITING

Rochester, New York, 14620, United States
AO di Perugia - Ospedale S. Maria della Misericordia
RECRUITING

Perugia, Umbria, 06156, Italy
Aalborg Universitetshospital
RECRUITING

Aalborg, 9000, Denmark
Aarhus Universitetshospital Skejby
RECRUITING

Aarhus N, 8200, Denmark
Adams Clinical Boston
RECRUITING

Boston, Massachusetts, 02116, United States
Adams Clinical Watertown
RECRUITING

Watertown, Massachusetts, 02472, United States
Ajou University Medical Center
RECRUITING

Gyeonggi-do, 16499, South Korea
Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
Alzheimer's Research and Treatment Center
RECRUITING

Stuart, Florida, 34997, United States
Alzheimer?s Research Australia
RECRUITING

Nedlands, Western Australia, 6009, Australia
Ambulates Gesundheitszentrum der Charité GmbH
RECRUITING

Berlin, 12200, Germany
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Banner Alzheimer?s Institute
RECRUITING

Phoenix, Arizona, 85006, United States
Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Brain Attack Center Ota Memorial Hospital
RECRUITING

Hiroshima, 720-0825, Japan
Brain Research Center B.V
RECRUITING

Amsterdam, 1081 GN, Netherlands
Brain Research Center Den Bosch
RECRUITING

's-Hertogenbosch, 5223 LA, Netherlands
Brain Research Center Zwolle
RECRUITING

Zwolle, 8025AZ, Netherlands
CEMEC - Centro Multidisciplinar de Estudos Clínicos
RECRUITING

São Bernardo do Campo, São Paulo, 09715-090, Brazil
CHU Amiens Hopital Sud
RECRUITING

Amiens Cedex1, 80054, France
CHU Dupruytren - Limoges
RECRUITING

Limoges, 87042, France
CHU de Rouen Hopital
RECRUITING

Rouen, 76031, France
CHUV Lausanne Méd.Neurologie
RECRUITING

Lausanne, 1011, Switzerland
CenExel iResearch, LLC
RECRUITING

Decatur, Georgia, 30030, United States
Cenexel California Neuroscience Research, LLC
RECRUITING

Sherman Oaks, California, 91403, United States
Center for Advanced Research & Education
RECRUITING

Gainesville, Georgia, 30501, United States
Centre Hospitalier Universitaire de Bordeaux Hopital Pellegrin
RECRUITING

Bordeaux, 33076, France
Centricity Research
RECRUITING

Halifax, Nova Scotia, B3S 1N2, Canada
Centrum Medyczne "MEDYK"
RECRUITING

Rzeszów, 35-326, Poland
Ch Pitie Salpetriere
RECRUITING

Paris, 75651, France
Charter Research - Winter Park/Orlando
RECRUITING

Orlando, Florida, 32803, United States
Chonnam National University Hospital
RECRUITING

Gwangju, 61469, South Korea
Clinica Clinilive ltda
RECRUITING

Maringá, Paraná, 87013-250, Brazil
Clinica Neurologica
RECRUITING

Joinville, Santa Catarina, 89202-190, Brazil
Clinical Research Center Sp. z o.o. MEDIC-R Spó?ka Komandytowa
RECRUITING

Późna, 61-731, Poland
Conquest Research - Lake Nona
RECRUITING

Orlando, Florida, 32832, United States
ECRC Experimental and Clinical Research Center, Charité Campus Berlin Buch, Memory Clinic
RECRUITING

Berlin, 13125, Germany
El Faro Health and Therapeutics
RECRUITING

Rio Grande City, Texas, 78582, United States
Ewha Womans University Hospital (Seoul)
RECRUITING

Seoul, 07804, South Korea
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Flourish Research ? Philadelphia
RECRUITING

Plymouth Meeting, Pennsylvania, 19462, United States
Fundacion Scherbovsky
RECRUITING

Mendoza, 5500, Argentina
Fundación ACE
RECRUITING

Barcelona, 08028, Spain
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Gadolin Research, LLC
RECRUITING

Beaumont, Texas, 77702, United States
Genge Partners Inc.
RECRUITING

Montreal, Quebec, H4A 3T2, Canada
German Center for Neurodegenerative Diseases (DZNE)
RECRUITING

Bonn, 53127, Germany
Great Lakes Clinical Trials Chicago d/b/a Flourish Research Andersonville
RECRUITING

Chicago, Illinois, 60640, United States
Groupement Hospitalier Est - Hôpital Neurologique
RECRUITING

Bron, 69677, France
Hanyang University Seoul Hospital
RECRUITING

Seoul, 04763, South Korea
Healthy Brain Clinic
RECRUITING

Long Beach, California, 90804, United States
Higashi-Shinjuku Clinic
RECRUITING

Tokyo, 169-0072, Japan
Hop Guillaume Et Rene Laennec
RECRUITING

Saint-Herblain, 44800, France
Hopital Gui de Chauliac
RECRUITING

Montpellier, 34295, France
Hospital Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Cantabria, 39011, Spain
Hospital Universitario la Fe
RECRUITING

Valencia, 46026, Spain
Hospital Victoria Eugenia
RECRUITING

Seville, 41009, Spain
Hospital Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
Hôpital Robertsau
RECRUITING

Strasbourg, 67000, France
Hôpitaux universitaires de Genève
RECRUITING

Geneva, 1211, Switzerland
Inha University Hospital
RECRUITING

Incheon, 22332, South Korea
Inselspital Bern Medizin Neurologie
RECRUITING

Bern, 3010, Switzerland
Instituto de Neurologia de Curitiba
RECRUITING

Curitiba, Paraná, 81210-310, Brazil
Instituto do Cerebro do Rio Grande do Sul
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
JEM Research LLC
RECRUITING

Atlantis, Florida, 33462, United States
K2 Medical Research-Winter Garden
RECRUITING

Clermont, Florida, 34711, United States
KaRa Institute of Neurological Diseases
RECRUITING

Macquarie Park, New South Wales, 2113, Australia
Kagawa University Hospital
RECRUITING

Kagawa, 761-0793, Japan
Kawartha Centre - Redefining Healthy Aging
RECRUITING

Peterborough, Ontario, K9H 2P4, Canada
Kerwin Medical Center
RECRUITING

Dallas, Texas, 75216, United States
Kobe University Hospital
RECRUITING

Hyōgo, 650-0017, Japan
Kochi Medical School Hospital
RECRUITING

Kochi, 783-8505, Japan
Korea University Guro Hospital
RECRUITING

Seoul, 08308, South Korea
Kotobuki Social Medical Corporation Tominaga Clinic
RECRUITING

Osaka, 556-0015, Japan
L2 Ip Instituto de Pesquisas Clinicas Ltda ME
RECRUITING

Brasília, Federal District, 70200-730, Brazil
LMU Klinikum, Neurologische Klinik und Poliklinik
RECRUITING

München, 81377, Germany
Lancashire and South Cumbria NHS Foundation Trust
RECRUITING

Preston, PR2 8DW, United Kingdom
Ludwig-Maximilians-Univ.
RECRUITING

München, 81377, Germany
Manchester Mental Health and Social Care Trust
RECRUITING

Manchester, M13 9WL, United Kingdom
Medizinische Fakultät Carl Gustav Carus
RECRUITING

Dresden, 01307, Germany
Mt.Olympus Medical Research
RECRUITING

Katy, Texas, 77450, United States
National Hospital Organization Hiroshima-Nishi Medical Center
RECRUITING

Hiroshima, 739-0696, Japan
NeuroProtect
RECRUITING

Warsaw, 01-684, Poland
Neuropraxis München Süd
RECRUITING

Unterhaching, 82008, Germany
Nuovo Ospedale Civile S. Agostino-Estense
RECRUITING

Modena, Emilia-Romagna, 41126, Italy
O?rodek Badawczo-Naukowo-Dydaktyczny Chorób Ot?piennych w ?cinawie
RECRUITING

?cinawa, 59-330, Poland
Oakland Clinical
RECRUITING

Oakland, California, 94609, United States
Okanagan Clinical Trials
RECRUITING

Kelowna, British Columbia, V1Y 1Z9, Canada
Okayama City Hospital
RECRUITING

Okayama, 700-8557, Japan
Ospedale Isola Tiberina - Gemelli Isola
RECRUITING

Rome, Lazio, 00186, Italy
Ospedale Regionale di Lugano - Civico
RECRUITING

Lugano, 6903, Switzerland
Otto-von-Guericke-Universität Magdeburg
RECRUITING

Magdeburg, 39120, Germany
Parkwood Institute Main Building
RECRUITING

London, Ontario, N6C0A7, Canada
Podlaskie Centrum Psychogeriatrii
RECRUITING

Bia?ystok, 15-756, Poland
Policlinico Universitario Agostino Gemelli
RECRUITING

Rome, Lazio, 00168, Italy
ProNeuro Centrum Medyczne
RECRUITING

?ory, 44-240, Poland
Pusan National University Hospital
RECRUITING

Busan, 602-739, South Korea
Queen Elizabeth Hospital
RECRUITING

Woodville, South Australia, 5011, Australia
Queen Elizabeth University Hospital Glasgow
RECRUITING

Glasgow, G51 4TF, United Kingdom
Quest Research Institute
RECRUITING

Farmington Hills, Michigan, 48334, United States
RE:Cognition Health
RECRUITING

London, W1G 8TA, United Kingdom
Re:Cognition Health
RECRUITING

Fairfax, Virginia, 22031, United States
Re:Cognition Health - Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
Re:Cognition Health Birmingham
RECRUITING

Birmingham, B16 8QQ, United Kingdom
ReMind UK
RECRUITING

Bath, BA1 3NG, United Kingdom
Rigshospitalet, Hukommelsesklinikken
RECRUITING

København Ø, 2100, Denmark
Rijikai Medical Corporation Katayama Medical Clinic
RECRUITING

Okayama, 710-0813, Japan
Riverside Clinical
RECRUITING

Riverside, California, 92506, United States
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sana Research, LLC
RECRUITING

Arlington, Virginia, 22205, United States
Scottish Brain Sciences
RECRUITING

Edinburgh, EH12 9DQ, United Kingdom
Senior Sp. Z O.O. Poradnia Psychogeriatryczna
RECRUITING

Sopot, 81-855, Poland
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, 463-707, South Korea
Southampton University Hospitals NHS Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom
Southern Neurology
RECRUITING

Kogarah, New South Wales, 2217, Australia
St George?s Hospital
RECRUITING

London, SW17 ORE, United Kingdom
St. Michael's Hospital
RECRUITING

Toronto, Ontario, M5B 1W8, Canada
St. Vincent's Hospital
RECRUITING

Gyeonggi-do, 442-723, South Korea
Summit Research Network Inc.
RECRUITING

Portland, Oregon, 97210, United States
Sun Valley Research Center, Inc.
RECRUITING

Imperial, California, 92251, United States
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Syberka-ClinHouse Sp. z o.o.
RECRUITING

B?dzin, 42-500, Poland
Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, 30-688, Poland
The Cognitive and Research Center of New Jersey
RECRUITING

Springfield, New Jersey, 07081, United States
The Ottawa Memory Clinic
RECRUITING

Ottawa, Ontario, K1Z 1G3, Canada
The University of Tokyo Hospital
RECRUITING

Tokyo, 113-8655, Japan
UCL Institute of Neurology
RECRUITING

London, WC1N 3BG, United Kingdom
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, Bavaria, 91054, Germany
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198-8440, United States
Universität Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitätsklinikum Jena, Klinik für Neurologie
RECRUITING

Jena, 07747, Germany
Universitätsklinikum Köln
RECRUITING

Cologne, 50937, Germany
Universitätsklinikum Münster
RECRUITING

Münster, 48149, Germany
Universitätsklinikum des Saarlandes Klinik f. Psychiatrie und Psychotherapie
RECRUITING

Homburg/Saar, 66421, Germany
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland
Uniwersytet Medyczny w Lodzi
RECRUITING

?ód?, 92-216, Poland
Visionary Investigators Network- Neurology Aventura
RECRUITING

Miami, Florida, 33133, United States
Warneford Hospital
RECRUITING

Oxford, OX3 7JX, United Kingdom
Yale University
RECRUITING

New Haven, Connecticut, 06510, United States
Zentralinstitut für Seelische Gesundheit Abt.Gerontopsychiatrie
RECRUITING

Mannheim, 68159, Germany

Conditions

Explore the condition pages connected to this study.

ALZHEIMERS DISEASE ALZHEIMERS DISEASE