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Can a diabetes drug and nasal insulin boost brain health?

NCT ID NCT06072963

Recruiting now Disease control Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study tests whether combining a daily oral diabetes medication (semaglutide) with a nasal insulin spray can improve memory, thinking, and blood flow in the brain. The trial enrolls older adults with mild cognitive impairment and metabolic syndrome, a group at high risk for dementia. Participants take the drugs for up to 12 months while researchers track changes in cognition and brain scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a combination of intranasal insulin (Actrapid) and oral semaglutide (Rybelsus)
What this could lead to
If it works, this could point toward a new way to slow cognitive decline in people at high risk for dementia.
What could go wrong
This is a small, early feasibility study. The combination may cause side effects like nausea or not improve cognition. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome Alzheimer disease Cognitive Dysfunction dementia metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE METABOLIC SYNDROME MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

  • Joseph Sagol Neuroscience center, Sheba Medical Center

    RECRUITING

    Ramat Gan, 5265601, Israel

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