Belly fat in midlife linked to Alzheimer's brain changes?
NCT ID NCT05077579
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at 240 adults aged 40-60 to see if being overweight or obese in midlife is linked to early signs of Alzheimer's in the brain. Participants will have metabolic tests and brain scans (MRI and PET) to measure inflammation, brain shrinkage, and protein buildup. The goal is to understand why midlife obesity may raise Alzheimer's risk, not to test a treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could reveal how excess body fat in midlife contributes to Alzheimer's disease, pointing to new prevention strategies.
- What could go wrong
- This is an observational study, not a treatment trial. It may not find clear links between obesity and Alzheimer's biomarkers, and results may not apply to all populations.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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