METABOLIC DISEASE

This study is testing a new, less invasive procedure called PSAM that aims to help people with obesity lose weight by slowing down how fast the stomach empties. The procedure uses an endoscope (a thin tube passed through the mouth) to make cuts in the stomach muscle, without remo…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience dangerous low blood sugar episodes despite using an automated insulin pump and continuous glucos…

This study tests whether taking a daily oil rich in linoleic acid (a type of omega-6 fat) can improve insulin resistance and other metabolic health markers in adults. 120 participants with insulin resistance will receive either the linoleic acid oil or a control oil for 8 weeks. …

This study looks at whether a medication called SGLT2 inhibitor, already used for diabetes and kidney disease, can improve blood flow to the heart in women with HIV who also have diabetes or kidney problems. About 80 women will be randomly assigned to health education alone or he…

This study tests whether an online training and peer support platform (Support-t) helps teenagers with type 1 diabetes prepare for moving from pediatric to adult healthcare. About 200 teens aged 14-16 from four Quebec hospitals will either receive usual care or also get access to…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This early-phase study tests a single-dose CRISPR treatment (CTX310) designed to edit a gene that controls fat levels in the blood. It is for adults aged 18 to 75 with severe high cholesterol or triglycerides that do not improve with standard medications. The main goal is to chec…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study looks at older adults (50+) with PTSD and ongoing insomnia. After a talk therapy for PTSD, those with remaining sleep issues will get a non-drug sleep program. Researchers will check if this improves sleep, PTSD symptoms, heart health markers like blood pressure, and q…

This study tests an online training and support platform designed to help adults with type 1 diabetes better manage their condition. About 322 participants will use the platform for 12 months, either through their usual clinic care or on their own. Researchers will measure change…

This study aims to understand how environmental factors like pollution, diet, and stress contribute to human diseases. Researchers will collect blood, urine, hair, and other samples from 2,000 healthy adults aged 18 and older. Participants may also complete surveys and provide sa…

This study follows 106 men who have had surgery for prostate cancer to see how their bladder control, sexual function, and overall health improve over time. Participants receive standard care resources and are monitored for physical activity, fitness, and quality of life. The goa…

This study aims to learn more about endocrine and metabolic disorders in children by examining their genes. Researchers will evaluate up to 15,000 children aged 3 months to 18 years with known or suspected conditions, along with their family members. The goal is to identify genet…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information so that future researchers can use them to discover what…

This study aims to learn more about rare disorders that affect how the body processes certain chemicals called purines and pyrimidines. These disorders can cause problems in the brain, blood, kidneys, and immune system, ranging from no symptoms to severe illness. Researchers will…

This study follows people with propionic acidemia (PA), a rare metabolic disorder, to learn how the disease affects the body over years. Participants aged 2 and older visit the clinic annually for tests like blood draws, heart checks, and brain scans. The goal is to better unders…

This study looks at how being overweight or obese in midlife (ages 40-60) might increase the risk of Alzheimer's disease. Researchers will use brain scans and blood tests to compare three groups: metabolically healthy lean people, metabolically healthy overweight/obese people, an…

This study looks at why night shift workers have higher risks for heart disease and diabetes. Researchers will test if eating only during certain hours (time-restricted eating) can improve blood vessel health and insulin sensitivity. The study involves 50 adults who have worked n…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study collects blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. The samples are stored in a biobank for future research on inflammation, metabolism, and other disease pathways. No treatments or interventions are given; the …

This study aims to better understand heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect medical information, images, and samples from up to 5,000 participants, including healthy volunteers and family members. The goal is to …

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic condition that causes intellectual disability, seizures, and behavior issues. Researchers will examine photos of participants' faces to find shared traits that could he…

This early-stage study is testing a new drug, SNS851, in 52 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo by injection. The main goal is to check for side effects, not to treat any disease.

This study aims to uncover the molecular mechanisms behind kidney disease, immune disorders, and complications in organ transplant patients. Researchers will analyze blood and urine samples from 5,000 participants to find genetic and protein markers that predict disease progressi…