METABOLIC DISEASE

This study is testing if a simple change to meal timing can help night shift workers. Researchers want to see if restricting eating to a specific daily window (time-restricted eating) can improve blood pressure and how the body processes sugar. They are recruiting 50 long-term ni…

This study is testing if a medication already used for diabetes and kidney disease can improve blood flow in the heart for women with HIV. Researchers want to see if better blood flow can lower their higher risk of heart attacks. The study will compare two groups: one receiving h…

This study is testing whether adding a specific oil rich in linoleic acid (a common omega-6 fat) to the daily diet can improve how the body uses insulin in adults who have insulin resistance. For 8 weeks, 120 participants in Chile will take either the test oil or a control blend …

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This is the first human trial of an experimental one-time treatment called CTX310, which uses CRISPR gene-editing technology. It aims to permanently lower harmful cholesterol and fat levels in the blood of adults whose levels don't respond well to existing medications. The study …

This is the first human study testing a new treatment called OPF-310, which involves transplanting specially encapsulated insulin-producing cells from pigs into people with unstable type 1 diabetes. The goal is to see if these transplanted cells can safely help control blood suga…

This study is testing whether an online training and peer support platform can help teenagers with type 1 diabetes better manage their health as they prepare to move from pediatric to adult healthcare. Researchers will compare the online platform plus usual care against usual car…

This study is testing whether an online training and peer support platform called 'Support' helps adults with type 1 diabetes manage their daily care. Researchers are comparing two groups: one where doctors recommend the platform as part of regular care, and another where people …

This study is testing a new, less invasive endoscopic procedure called Pylorus Sparing Antral Myotomy (PSAM) for weight loss. It involves making a small cut in the stomach muscle to slow down how quickly food leaves the stomach, which may help people feel full longer and lose wei…

This study aims to see if adding short daily stair climbing to regular brisk walking lowers high blood pressure more effectively than walking alone in inactive adults who are overweight and have hypertension. It will involve 450 participants split into three groups: one combining…

This study is testing a 12-week wellness program designed to help men recover after prostate removal surgery. The program combines online education, group exercise, and pelvic floor muscle training to improve bladder control, sexual function, and overall fitness. Researchers want…

This study aims to understand how everyday environmental factors like pollution, diet, and stress contribute to disease and inflammation. Researchers will collect various samples—such as blood, saliva, urine, and even household dust—from up to 2,000 healthy adults. The goal is to…

This study aims to understand why kidney disease happens, gets worse, or leads to complications like infections or heart problems. Researchers will follow 5,000 adult patients with or at risk for kidney disease for 10 years, collecting blood and urine samples. They will analyze t…

This study aims to find out if boys with a rare genetic brain disorder called creatine transporter deficiency (CTD) share similar facial features. Researchers will analyze photos of 19 males with CTD, aged 2 to 40, who are already part of a related NIH study. The goal is to ident…

This study aims to create a long-term collection of biological samples to help researchers better understand heart and blood vessel diseases. It will collect blood, urine, and stool samples from 500 adults who have or are at risk for these conditions. The goal is to build a share…

This study aims to learn more about rare and poorly understood diseases that affect the heart and blood vessels. Researchers will enroll up to 5,000 people, including patients, their relatives, and healthy volunteers, to collect medical data, images, and samples. The goal is to i…

This study aims to better understand propionic acidemia, a rare genetic disorder where the body cannot properly break down certain parts of food. Researchers will observe over 1,000 participants, including people with the condition and some family members, over several years thro…

This study aims to better understand and diagnose rare hormone and metabolism disorders in children. Researchers will evaluate up to 15,000 children and their family members, using medical exams, imaging, and genetic testing to learn how these conditions develop and are inherited…

This study is creating a large collection of blood, urine, stool, and tissue samples from people with and without heart or metabolic diseases. The goal is to build a library for future researchers to use, helping them understand the causes and effects of these common conditions f…

This is the first study in humans to check if a new drug called SNS851 is safe and how it moves through the body. It will involve 52 healthy adults who will receive injections under the skin. The main goal is to see what side effects occur and how well people tolerate the drug.

This study aims to better understand a group of rare genetic disorders that affect how the body processes certain chemicals, which can cause problems with the brain, blood, kidneys, and immune system. Researchers will observe up to 999 participants, including people with these di…