New stomach muscle cut aims to curb appetite and shed pounds

NCT ID NCT05711758

Recruiting now Disease control Sponsor: Christopher C. Thompson, MD, MSc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests a new procedure called PSAM (Pylorus-Sparing Antral Myotomy) for weight loss in 30 adults with obesity. The procedure involves cutting some stomach muscles to slow down how fast food leaves the stomach, which may help people feel full longer and lose weight. Researchers are checking if it is safe, tolerable, and effective on its own, without combining it with other weight-loss procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pylorus-Sparing Antral Myotomy (PSAM) procedure
What this could lead to: If successful, PSAM could offer a new, less invasive weight-loss option for people with obesity, potentially reducing procedure time and risks compared to current methods.
What could go wrong: This is a very small pilot study with only 30 people, so results may not apply to everyone. The procedure is new and its long-term safety and effectiveness are unknown.

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Conditions

The condition(s) this trial relates to.

metabolic disease morbid obesity Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DELAYED GASTRIC EMPTYING FOLLOWING PROCEDURE METABOLIC DISEASE OBESITY OBESITY, MORBID OBESITY, PRIMARY

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States

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