Brain implant aims to quiet voices in Drug-Resistant schizophrenia

NCT ID NCT06257056

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing a brain implant called deep brain stimulation (DBS) for people with schizophrenia that hasn't improved with standard treatments. The device delivers electrical pulses to specific brain areas to try to reduce psychotic symptoms. Ten participants will be followed for safety and any symptom changes over eight months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
deep brain stimulation device
What this could lead to
If successful, this could point toward a new treatment option for people with schizophrenia that doesn't respond to standard medications.
What could go wrong
This is a very small, early pilot study with only 10 participants. The approach is experimental, and safety and effectiveness are not yet proven. Brain surgery and device implantation carry risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Schizophrenia Schizophrenia, Treatment-Resistant treatment-refractory schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

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