Flashing lights and tones could stop Alzheimer's before it starts

NCT ID NCT05776641

Recruiting now Prevention Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a device that flashes light and plays sound at 40Hz can prevent Alzheimer's disease in people at risk. 200 adults aged 55-90 with a family history of Alzheimer's will use the device at home for 60 minutes daily over 12 months. Researchers will measure changes in brain amyloid and tau proteins using PET scans to see if the stimulation slows or stops disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GENUS light and sound device (40Hz gamma entrainment)
What this could lead to: If it works, this could point toward a simple, non-invasive way to prevent Alzheimer's disease in people with a family history.
What could go wrong: This is an early-stage study with no phase designation, so results are uncertain. The device may not reduce amyloid or tau buildup in humans as it did in mice, and daily use for a year may be challenging.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE FAMILY MEMBERS

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Massachusetts Institute of Technology
RECRUITING

Cambridge, Massachusetts, 02139, United States

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