COGNITIVE DYSFUNCTION

This large study is testing a simple, low-cost digital screening tool called ToolboxDetect to help primary care doctors identify early signs of cognitive decline or dementia in adults aged 65 and older. Over 41,000 participants from diverse backgrounds will take a short computer …

This pilot study is testing a type of talk therapy called Metacognitive Interpersonal Therapy (MIT-ED) for adults with various eating disorders, including those who are underweight. The therapy aims to help people understand and manage the negative thoughts and feelings that driv…

This study compares two approaches to help stroke survivors with mild to moderate thinking problems. Both groups use a web-based computer game that trains how quickly they process information. One group also gets in-lab training on everyday activities, while the other focuses on …

This pilot study tests whether a telehealth program called HOBSCOTCH-PACS can help people with long COVID manage memory and thinking problems. Ten participants will attend nine virtual coaching sessions and complete questionnaires about their quality of life and cognitive functio…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

This pilot study tests a home-based program called HOBSCOTCH, designed to help people with multiple sclerosis manage memory and thinking problems. Eleven participants will attend virtual coaching sessions and complete questionnaires about their quality of life and cognitive funct…

This study tests a special exercise program for older Veterans with dementia living in VA nursing homes. The program, called PLIÉ, combines gentle movement and mental focus to improve physical function, mood, and social engagement. Staff will be trained to lead the classes, and r…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study looks at how thinking, memory, and movement change in older adults with conditions like dementia or Parkinson's disease. Researchers will use tests, brain scans, and lab samples to find clues for earlier diagnosis and better care. About 260 people, including healthy vo…

This study examines whether self-awareness—knowing your own strengths and limits—can predict fall risk in older adults and rehab patients. About 100 participants aged 60-85 will complete cognitive tests, questionnaires, and walking assessments with wearable sensors. The goal is t…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study uses blood samples and health data from over 13,000 older adults to see if Alzheimer's-related blood markers differ between men and women. Researchers aim to create a sex-specific risk score that could help predict the disease earlier and personalize future treatments.…

This study looks at why depression often comes back in older adults and how it affects memory and thinking. Researchers will follow 210 people aged 60 and older, some currently depressed and some in remission, using brain scans and daily mood tracking. The goal is to find biologi…