COGNITIVE DYSFUNCTION

This study aims to understand how personalized nutrition and lifestyle management can help people with declining kidney function stay healthier and slow disease progression. Researchers will follow 1,800 adults with reduced kidney function (not on dialysis) for up to ten years, t…

This study is testing whether an investigational drug called JNJ-63733657 can slow the progression of early Alzheimer's disease. The drug is an antibody designed to target and clear tau protein, one of the key abnormal proteins that builds up in the Alzheimer's brain. About 523 p…

This study is testing a new, quick iPad-based tool called ToolboxDetect to help primary care doctors spot early signs of memory and thinking problems in older adults during their annual wellness visits. It aims to see if this 7-8 minute test is better than usual care at finding c…

This small pilot study is testing whether a home-based coaching program originally developed for epilepsy can help people with Parkinson's disease. Participants attend nine virtual sessions with a coach to learn self-management strategies for memory and thinking problems. The mai…

This study is testing two different training programs for adults who have had a stroke and are still experiencing mild-to-moderate problems with memory, attention, or thinking speed. Both programs use a web-based computer 'game' designed to improve how quickly the brain processes…

This study is testing whether digital brain games (on a device) or physical, hands-on puzzles and activities are better at helping older adults with mild to moderate Alzheimer's disease. It involves over 500 participants in Portugal and aims to see which type of activity best sup…

This small pilot study is testing whether a home-based coaching program, originally designed for epilepsy, can be adapted to help people with multiple sclerosis (MS). Participants will have nine one-on-one virtual sessions with a coach to learn self-management strategies for memo…

This small pilot study is testing whether a home-based coaching program, originally designed for epilepsy, can be adapted to help people with Long COVID. Ten participants with self-reported memory and thinking problems will work one-on-one with a coach over nine virtual sessions.…

This study is testing a special group exercise program called PLIÉ for Veterans with dementia living in VA long-term care centers. The program aims to help residents improve their physical function, mood, and social engagement. Researchers are also training staff to lead these cl…

This study aims to understand if a person's self-awareness—their ability to recognize their own strengths and limitations—is linked to their risk of falling while walking. Researchers will test about 100 adults aged 60-85, measuring their thinking skills, self-awareness, and walk…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for up to five years, tracking their cognitive function and taking brain scans. The goal is to i…

This study aims to understand why depression often returns in people over 60. Researchers will use brain scans and daily mood tracking to find patterns that predict who is at risk for another depressive episode. They will also see how these brain changes relate to memory and thin…

This study aims to understand how blood tests for Alzheimer's disease work differently in men and women. Researchers will analyze blood samples from over 13,000 older adults to see if these tests predict dementia risk differently based on sex and other health factors. The goal is…