COGNITIVE DYSFUNCTION

This study tests a new tool called ToolBoxDetect that helps doctors quickly and easily check for early signs of memory loss or dementia during regular visits. About 41,500 adults aged 65 and older from diverse primary care clinics will take a short computer-based test. The goal i…

This small pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease who have memory or thinking problems. Ten participants will work one-on-one with a coach in nine virtual sessions, lear…

This study tests a type of talk therapy called Metacognitive Interpersonal Therapy for Eating Disorders (MIT-ED) in 64 adults with various eating disorders, including those who are underweight. The therapy focuses on helping people understand and change unhelpful thinking pattern…

This small pilot study is testing whether a program called HOBSCOTCH, originally designed for epilepsy, can be adapted to help people with long COVID who have memory and thinking problems. Ten participants will attend nine virtual coaching sessions and complete surveys about thei…

This study tests a special exercise program for older Veterans with dementia living in VA nursing homes. The program, called PLIÉ, combines gentle movement and mental focus to improve physical function, mood, and social engagement. Staff will be trained to lead the classes, and r…

This small pilot study is testing whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted to help people with multiple sclerosis (MS) who have memory and thinking difficulties. Eleven participants will work one-on-one with a coach in nine v…

This study compares two approaches to help stroke survivors with mild-to-moderate thinking problems. Both use a computer game to train how quickly the brain processes information. One group also practices everyday tasks and learns ways to use these skills at home, while the other…

This study observes 260 Chinese adults with memory problems, Parkinson's disease, or healthy aging to better understand how the brain changes. Participants get free memory tests, brain scans, and lab work. The goal is to find better ways to diagnose and care for cognitive disorde…

This study follows 210 older adults with depression to find brain patterns that predict when depression will return. Participants have brain scans and thinking tests over time. The goal is to understand why depression recurs, not to test a new treatment.

This study looks at how well older adults and rehab patients understand their own walking abilities and whether that affects their risk of falling. About 100 people aged 60-85 will take cognitive tests, fill out questionnaires, and walk with sensors. The goal is to see if poor se…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to see how memory, thinking, and daily activities change over time. Researchers will compare the two groups and look for risk factors that may lead to cognitive decline, dementia, or str…

This study looks at blood markers for Alzheimer's and related dementias in over 13,000 older adults. Researchers want to see if these markers change differently over time in men versus women, and how health conditions and genetics affect them. The goal is to create a personalized…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition affects overall health and disease progression. Researchers will track heart health, bone health, thinking skills, and daily function using hospital records and a mobile app. The g…