Scientists hunt for clues to stop Late-Life depression from coming back

NCT ID NCT05331599

Ongoing Knowledge-focused Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at why depression often comes back in older adults and how it affects memory and thinking. Researchers will follow 210 people aged 60 and older, some currently depressed and some in remission, using brain scans and daily mood tracking. The goal is to find biological signs that predict who is at risk for another depressive episode.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify which older adults are at highest risk for depression relapse, enabling earlier and more personalized care.
What could go wrong: This is an observational study, not testing a treatment. It may not lead to direct clinical changes, and findings may not apply to all older adults with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Depression depressive disorder major depressive disorder Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE DYSFUNCTION DEPRESSION IN OLD AGE RECURRENCE

Contacts and locations

Locations

University of Illinois at Chicago

Chicago, Illinois, 60607, United States

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