Scientists hunt for clues to stop Late-Life depression from coming back
NCT ID NCT05331599
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at why depression often comes back in older adults and how it affects memory and thinking. Researchers will follow 210 people aged 60 and older, some currently depressed and some in remission, using brain scans and daily mood tracking. The goal is to find biological signs that predict who is at risk for another depressive episode.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could help identify which older adults are at highest risk for depression relapse, enabling earlier and more personalized care.
What could go wrong
This is an observational study, not testing a treatment. It may not lead to direct clinical changes, and findings may not apply to all older adults with depression.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Illinois at Chicago
Chicago, Illinois, 60607, United States