COGNITIVE DYSFUNCTION

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This study tested whether adding structured supportive psychotherapy to the antipsychotic drug risperidone helps improve thinking and reduce inflammation in people with schizophrenia. Forty-six male patients were split into two groups: one received risperidone plus 12 therapy ses…

This study tested a 12-week intensive exercise program (aerobic and resistance training) in 58 adults aged 40-85 with type 2 diabetes and mild cognitive issues. The goal was to see if exercise could improve thinking, blood sugar, inflammation, and physical function. Results may h…

This study tested an experimental drug called SAGE-718 in 26 people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The main goal was to see if the drug is safe and tolerable, and to check for any effects on thinking and mood. Participants took SAGE-71…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested a virtual reality (VR) program designed to stimulate thinking skills in 45 people with mild cognitive impairment. Participants used VR headsets to do tasks like virtual shopping and recipe sequencing over 8 sessions. The goal was to see if the VR program was eas…

This study tested whether a herbal supplement called Redormin 500 (made from valerian and hop extracts) can help people with occasional sleep problems think more clearly during the day and feel better overall. Forty healthy adults with mild sleep issues took either the supplement…

This study tested whether adding virtual reality (VR) to standard computer-based cognitive training could improve memory, attention, and thinking skills in older adults with mild cognitive impairment. 70 participants completed a 12-week program of cognitive exercises, with one gr…

This study tested a new combination of two talk therapies for adults with eating disorders who are not underweight. Twenty participants were randomly assigned to either standard cognitive behavioral therapy (CBT-E) or a mix of CBT and metacognitive interpersonal therapy (CBT-F+MI…

This study tested whether combining balance exercises with mental tasks (like naming animals) can improve balance and mild memory problems in people with diabetic nerve damage. Fifty adults aged 50 and older with type 2 diabetes and mild cognitive issues took part in 24 sessions …

This study tested a training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to recreate familiar situations, aiming to improve orientation to time, place, and person. 126 participants were assigned to either the training…

This study tested two types of mental exercises in 514 older adults with mild to moderate Alzheimer's disease. One group used a computer program with brain games, while the other used physical puzzles and memory cards. The goal was to see if these activities could improve thinkin…

This study tested whether a low-level magnetic therapy device, used at home, is safe and practical for people with Long COVID who have memory and thinking problems. Thirty adults with persistent cognitive issues after COVID-19 used the device daily for 4 weeks, then were followed…

This study tested whether a procedure called a stellate ganglion block (SGB), given with standard medication, could improve thinking and memory in people with Alzheimer's disease. Forty participants were randomly assigned to receive either SGB plus standard drugs or standard drug…

This study tested a new exercise device called FitMi AD in 31 people with mild cognitive impairment or mild dementia due to Alzheimer's. The device uses sensors to track movements while users follow exercises shown on a computer screen. Researchers measured improvements in balanc…

This study tested whether an 8-week mindfulness program could reduce anxiety in 168 older adults who have memory concerns but normal cognitive test scores. Participants were randomly assigned to either mindfulness training or a health education program. The goal was to see if min…

This study tested whether a program that combines talk therapy, brain training, and healthy lifestyle advice is practical and helpful for people with conditions like mild traumatic brain injury, multiple sclerosis, long COVID, or mild cognitive impairment. Fifteen participants we…

This small study tested an experimental drug called SAGE-718 in 18 people with Parkinson's disease who also had mild thinking and memory problems. The main goal was to see if the drug was safe and tolerable. Researchers also looked at whether it might help with thinking, mood, an…

This study tested a drug called SAGE-718 in 86 people with Parkinson's disease who have mild memory or thinking problems. Participants took either the drug or a placebo pill for a set time. The main goal was to see if SAGE-718 could improve processing speed, measured by a symbol-…

This study tested whether a noninvasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory in people with mild cognitive impairment (MCI). 69 participants were randomly assigned to receive active rTMS to one of two brain areas or a placebo tre…

This study looked at whether doing short, frequent exercise sessions (called 'exercise snacks') is better for your mental health than doing longer, less frequent workouts. 180 healthy young adults were split into two groups: one did six 15-minute cycling sessions per week, the ot…

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This study placed 15 healthy volunteers in a natural cave with no access to time cues for 40 days. Researchers measured how their sense of time, sleep cycles, stress levels, and group coordination changed. The goal was to understand how humans adapt to extreme isolation and time …

This study looked at whether using EEG brain-wave monitoring during general anesthesia helps doctors give the right amount of medicine. The goal was to help patients wake up faster after surgery and reduce memory or thinking problems. About 100 adults having surgery took part. Re…

This study looked at whether a 30-minute walk outside in a green area helps people recover from mental tiredness and stress better than walking on a treadmill indoors. 80 healthy young adults were split into two groups: one walked outdoors in nature, the other walked indoors in a…

This study of 102 heart surgery patients examined whether drops in brain oxygen levels during surgery are linked to memory or thinking problems after the operation. Researchers used a special monitor to track brain oxygen and tested patients' thinking skills before and after surg…

This study looked at whether continuously measuring oxygen levels in the brain during heart bypass surgery can reduce memory and thinking problems after the operation. 326 older adults (age 60+) having planned heart surgery took part. Researchers compared standard care to care gu…

This study looked at 134 adults with chronic sinusitis to see if sleep problems and daytime tiredness predict declines in thinking skills and daily functioning. Participants filled out questionnaires about their symptoms and quality of life. The goal was to better understand how …

This study looked at whether shining a special light on the head (called transcranial photobiomodulation) can improve blood flow in the brain and boost thinking skills. 24 healthy adults aged 18 to 80 took part. The goal was to gather information, not to treat or cure any disease…