COGNITIVE DYSFUNCTION

This study tested if a temporary nerve-blocking injection in the neck, given alongside standard Alzheimer's medications, could help improve thinking, memory, and daily life for people with the disease. Researchers compared two groups over six months: one received the injection pr…

This study tested whether a 12-week intensive exercise program could improve thinking skills, blood sugar control, and overall health in middle-aged and older adults with type 2 diabetes. Researchers enrolled 58 participants, some of whom were at higher risk for memory and thinki…

This small study tested whether adding structured supportive talk therapy to standard schizophrenia medication (risperidone) could improve thinking skills and reduce body inflammation better than medication alone. It involved 46 men with recent schizophrenia diagnoses over 6 week…

This study tested whether using a special monitor to track oxygen levels in the brain during heart bypass surgery could help prevent memory and thinking problems after the operation. Researchers enrolled 326 patients aged 60 and older. They compared standard care to using the mon…

This study tested whether a 24-week home-based program of physical activity and brain training could prevent or delay memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older who were at high risk for memory decline. They compared different …

This study tested the safety and side effects of an experimental drug called SAGE-718 in people with Parkinson's disease who have mild thinking and memory problems. Eighteen participants with early to moderate Parkinson's took the drug to see how well they tolerated it and whethe…

This study tested the safety and side effects of an investigational drug called SAGE-718 in people with early memory problems or mild dementia due to Alzheimer's disease. It involved 26 participants and also looked at whether the drug had any effects on their thinking skills and …

This study tested whether closely monitoring a patient's brain waves (EEG) during general anesthesia helps doctors give the right amount of sleep medicine. Researchers wanted to see if this personalized approach helps patients wake up faster after surgery and reduces problems wit…

This small, completed study tested whether a magnetic therapy device could be used safely and easily at home by people with Long COVID brain fog. It involved 30 adults who had experienced cognitive problems for at least six months after a COVID-19 infection. The main goal was to …

This study tested whether an 8-week mindfulness course could reduce anxiety and improve mental wellbeing in older adults who are worried about their memory but still test normally. Researchers compared the mindfulness program to a health education course in 168 participants acros…

This small, completed pilot study tested whether a personalized program combining talk therapy, brain training exercises, and lifestyle advice is practical and helpful for people with thinking problems from conditions like brain injury, multiple sclerosis, or mild memory loss. Th…

This study tested whether a noninvasive brain stimulation technique could improve memory in people with mild cognitive impairment (MCI), an early stage of memory loss. 69 participants were randomly assigned to receive either active stimulation to one of two brain areas or a place…

This study tested a new computer-guided exercise device called FitMi AD for people with mild memory problems or early Alzheimer's disease. The device uses sensors to track movements as people follow exercises shown on a screen. Researchers wanted to see if using this system for 3…

This study tested whether an investigational drug called SAGE-718 could improve cognitive performance, specifically thinking speed, in people with Parkinson's disease who have mild thinking problems. 86 participants were randomly assigned to receive either the drug or a placebo f…

This study tested whether walking in a green outdoor space helps people bounce back from mental tiredness and stress better than walking indoors. Researchers had 80 healthy young adults take a 30-minute walk, either outside in a forest park or inside on a treadmill in a plain roo…

This study aimed to understand how a non-invasive light therapy, called transcranial photobiomodulation, affects brain blood vessel health and cognitive function like memory and thinking. It involved 24 adults aged 18-80 who received up to eight light therapy sessions over four w…

This study looked at whether drops in brain oxygen levels during heart surgery are connected to memory and thinking problems that can happen after the operation. Researchers monitored 102 adult patients having planned heart surgery to see if those who had low brain oxygen were mo…

This study looked at whether sleep problems and daytime tiredness in people with chronic sinusitis (CRS) can predict declines in thinking skills and physical function. Researchers surveyed 134 adult patients with CRS using questionnaires about their sleep, fatigue, and quality of…