Could a new pill help Parkinson's patients think more clearly?
NCT ID NCT04476017
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This small study tested an experimental drug called SAGE-718 in 18 people with Parkinson's disease who also had mild thinking and memory problems. The main goal was to see if the drug was safe and tolerable. Researchers also looked at whether it might help with thinking, mood, and movement symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SAGE-718 (oral tablets)
What this could lead to
If successful, this could point toward a treatment to ease thinking and memory problems in people with Parkinson's disease.
What could go wrong
This was a very small, early-phase study with only 18 participants, so results may not apply broadly. The drug's effectiveness is still uncertain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sage Investigational Site
Long Beach, California, 90806, United States
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Sage Investigational Site
Port Charlotte, Florida, 33980, United States
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Sage Investigational Site
West Palm Beach, Florida, 33407, United States
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Sage Investigational Site
Chicago, Illinois, 60612, United States