New pill SAGE-718 tested for Alzheimer's memory loss

NCT ID NCT04602624

Completed Disease control Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested an experimental drug called SAGE-718 in 26 people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The main goal was to see if the drug is safe and tolerable, and to check for any effects on thinking and mood. Participants took SAGE-718 tablets by mouth, and researchers monitored side effects and changes in vital signs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAGE-718 oral tablets
What this could lead to: If successful, this could point toward a new treatment option to help manage cognitive and neuropsychiatric symptoms in early Alzheimer's disease.
What could go wrong: This is a small, early-phase trial (26 participants) focused on safety, not proof of effectiveness. The drug may not show meaningful cognitive benefits or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease cognitive disorder Cognitive Dysfunction dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE COGNITIVE DYSFUNCTION MILD DEMENTIA

Contacts and locations

Locations

Sage Investigational Site

Phoenix, Arizona, 85044, United States
Sage Investigational Site

Redlands, California, 92374, United States
Sage Investigational Site

Miami, Florida, 33137, United States
Sage Investigational Site

St. Petersburg, Florida, 33713, United States
Sage Investigational Site

Decatur, Georgia, 30030, United States
Sage Investigational Site

Decatur, Georgia, 30033, United States
Sage Investigational Site

Gaithersburg, Maryland, 20877, United States
Sage Investigational Site

Farmington Hills, Michigan, 48334, United States
Sage Investigational Site

Omaha, Nebraska, 68130, United States
Sage Investigational Site

North Canton, Ohio, 44720, United States

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