New pill SAGE-718 tested for Alzheimer's memory loss
NCT ID NCT04602624
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested an experimental drug called SAGE-718 in 26 people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The main goal was to see if the drug is safe and tolerable, and to check for any effects on thinking and mood. Participants took SAGE-718 tablets by mouth, and researchers monitored side effects and changes in vital signs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SAGE-718 oral tablets
What this could lead to
If successful, this could point toward a new treatment option to help manage cognitive and neuropsychiatric symptoms in early Alzheimer's disease.
What could go wrong
This is a small, early-phase trial (26 participants) focused on safety, not proof of effectiveness. The drug may not show meaningful cognitive benefits or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sage Investigational Site
Phoenix, Arizona, 85044, United States
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Sage Investigational Site
Redlands, California, 92374, United States
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Sage Investigational Site
Miami, Florida, 33137, United States
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Sage Investigational Site
St. Petersburg, Florida, 33713, United States
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Sage Investigational Site
Decatur, Georgia, 30030, United States
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Sage Investigational Site
Decatur, Georgia, 30033, United States
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Sage Investigational Site
Gaithersburg, Maryland, 20877, United States
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Sage Investigational Site
Farmington Hills, Michigan, 48334, United States
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Sage Investigational Site
Omaha, Nebraska, 68130, United States
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Sage Investigational Site
North Canton, Ohio, 44720, United States