PSYCHOSIS

This study is testing whether adding a purified cannabis compound called cannabidiol (CBD) can improve the effects of the antipsychotic drug clozapine for people with severe, treatment-resistant psychosis. About 250 participants who haven't responded well to clozapine alone will …

This study aims to see if adding cannabidiol (CBD), a non-intoxicating compound from cannabis, to standard antipsychotic medication can better control symptoms in young people experiencing their first psychotic episode. It will involve 250 participants aged 16-40 who haven't resp…

This study is testing a specialized therapy program designed to help people experiencing their first episode of psychosis reduce or quit using cannabis. The goal is to see if this support leads to fewer relapses and better mental health. The program involves weekly one-on-one ses…

This study is testing if a supervised strength training program can prevent harmful weight gain and improve physical health in people recently diagnosed with psychosis who are starting antipsychotic medication. The trial will involve 40 participants who will either start a 12-wee…

This study is testing whether a 'link worker' support program can help adults with severe mental illness, who haven't seen a dentist in over three years, attend a routine dental check-up. The goal is to see if this extra support leads to better oral health and quality of life com…

This study is testing a 12-week online program designed to improve mood and motivation in people with schizophrenia or those at high risk for developing psychosis. Participants will complete one 20-30 minute session each week, focusing on supporting goal-directed behavior. The st…

This small pilot study is testing whether a form of talk therapy (cognitive-behavioural therapy) can be successfully adapted to be more culturally relevant for Black people of African and Caribbean heritage who experience psychosis. Six participants will receive up to 16 therapy …

This study is testing if two different types of non-invasive brain stimulation can help improve thinking, memory, and social skills in people with schizophrenia who haven't responded well to standard medications. Ninety participants will receive either an accelerated stimulation …

This study is testing whether Narrative Exposure Therapy (NET), a type of talk therapy that helps people process traumatic memories, is practical and helpful for adults with psychosis who have experienced trauma. Participants will work with a therapist and complete regular questi…

This research aims to understand how a brain chemical called glutamate is linked to memory and attention problems in people who have experienced psychosis. It will involve brain scans and a safe, non-invasive brain stimulation technique to see if glutamate levels can help predict…

This study aims to understand how a person's sense of self and the story they tell about their life relates to their well-being and recovery after a first episode of psychosis. Researchers will compare 96 participants, including those with a recent first episode, those with longe…

This study aims to understand how health education affects treatment attitudes in people with schizophrenia during hospital stays. Researchers will provide educational materials to 34 hospitalized patients and measure their knowledge and attitudes before and after. The study will…

This study aims to understand how decision-making works in people with recent psychosis. Researchers will give 24 participants single doses of two different drugs (modafinil and d-serine) and a placebo during separate visits. They will use brain scans and computer games to see if…