Can brain chemistry predict who benefits from stimulation?

NCT ID NCT07196423

Recruiting now Knowledge-focused Sponsor: University of Nottingham Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study investigates how the brain chemical glutamate relates to memory and attention in people who have recently experienced psychosis. Researchers will use brain scans and a mild electrical stimulation technique called tDCS to see if glutamate levels can predict who responds to stimulation. The goal is to better understand brain chemistry and potentially tailor future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial direct current stimulation (tDCS)
What this could lead to: If successful, this could lead to a way to predict which patients with psychosis will benefit from brain stimulation, allowing more personalized treatment.
What could go wrong: This is an early-stage study with only 106 participants, focused on understanding brain chemistry rather than testing a treatment. The findings may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

psychotic disorder Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FIRST EPISODE PSYCHOSIS (FEP) PSYCHOSIS

Contacts and locations

Locations

University of Nottingham
RECRUITING

Nottingham, Nottinghamshire, NG7 2RD, United Kingdom

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