Talking therapy may keep psychosis at bay for High-Risk teens

NCT ID NCT07093671

Recruiting now Disease control Sponsor: Marco Armando Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 5 times

Summary

This study tests whether a type of talk therapy called Mentalization-Based Treatment (MBT) can help young people (ages 14–30) who are at high risk for psychosis avoid developing the condition. Participants will receive either MBT plus standard care or standard care alone for 24 weeks. Researchers will track who transitions to psychosis and how symptoms change over 48 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mentalization-Based Treatment (MBT) plus Need-Based Clinical Interventions (NBCI)
What this could lead to: If it works, this could offer a new psychological therapy to help young people at high risk for psychosis avoid developing full-blown psychosis.
What could go wrong: This is a relatively small, early-stage trial testing a talk therapy, not a drug. The effect may be modest, and results may not apply to all at-risk youth.

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders psychotic disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSYCHOSIS

Contacts and locations

Locations

CHUV
RECRUITING

Lausanne, 1011, Switzerland

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