Could a ketone drink help stabilize bipolar disorder?

NCT ID NCT06335875

Completed Symptom relief Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small pilot study tested whether a ketone ester drink combined with a low-glycemic diet could help people with bipolar disorder. Fifteen adults with bipolar I or II took the supplement twice daily and made simple diet changes for several weeks. Researchers measured blood ketone levels and glucose stability to see if the approach was feasible and had any effect on mood symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketone ester beverage (Juvenescence Cognitive Switch™) and a low-glycemic-index diet
What this could lead to: If it works, this could point toward a dietary approach to help stabilize mood in bipolar disorder.
What could go wrong: This is a very small, early pilot study with only 15 people and no placebo group, so results may not be reliable or apply to everyone. The diet and supplement may be hard to stick with long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER

Contacts and locations

Locations

Domino's Farms

Ann Arbor, Michigan, 48105, United States
University Hospital

Ann Arbor, Michigan, 48109, United States

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