New behavioral program aims to solve medication adherence in bipolar disorder

NCT ID NCT04622150

Completed Disease control Sponsor: Case Western Reserve University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

About half of people with bipolar disorder struggle to take their medication as prescribed, which can lead to severe consequences. This study tested a customized program called Customized Adherence Enhancement (CAE) that includes education, motivational interviewing, and help with medication routines. Researchers enrolled 190 adults with bipolar disorder in public mental health clinics to see if CAE improves adherence compared to usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Customized Adherence Enhancement (CAE) - a behavioral program with modules like education, motivational interviewing, and medication routines
What this could lead to: If it works, this could provide a practical, evidence-based tool for mental health clinics to help people with bipolar disorder take their medication more consistently.
What could go wrong: This is a completed trial with 190 participants, but it tests a behavioral intervention, not a drug, so results may be modest and depend on how well clinics adopt the program.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BIPOLAR DISORDER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

bipolar disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER

Contacts and locations

Locations

MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
The Nord Center

Lorain, Ohio, 44053, United States
W.O. Walker Center

Cleveland, Ohio, 44106, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.