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Gut bacteria may lift mood in bipolar depression

NCT ID NCT05762887

Completed Symptom relief Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking probiotics (good bacteria) can reduce depressive symptoms in people with bipolar disorder. 141 adults were randomly assigned to receive either probiotics or a placebo for 12 weeks. The goal was to see if probiotics could improve mood and reduce depression scores.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
probiotics
What this could lead to
If it works, this could point toward a simple, natural supplement to help manage depression in bipolar disorder.
What could go wrong
This is a small, early-stage study. Probiotics may not work for everyone, and the results may not apply to all people with bipolar disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER

Contacts and locations

Locations

  • University of Sao Paulo

    São Paulo, São Paulo, 05403010, Brazil

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