BIPOLAR DISORDER

This study looks at whether combining medication with one-on-one cognitive behavioral therapy helps people with mental health disorders like anxiety, depression, bipolar disorder, and schizophrenia. 107 adults aged 18-65 with an IQ of 80 or higher took part. The goal is to see if…

This study tests whether a personalized smartphone app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression and high blood pressure take their medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditio…

This study looks at whether involving bipolar patients in decisions about their preventive treatment helps them take their medication as prescribed. Researchers will compare standard care to a shared decision-making plan in 300 adults after a mood episode. The goal is to see if t…

This study tests the long-term safety and effectiveness of azetukalner in 400 adults with bipolar I or II depression who already completed a previous study on the same drug. Participants will take the medication openly (everyone knows they are getting it) for an extended period. …

This study tests a customized program called Customized Adherence Enhancement (CAE) to help people with bipolar disorder take their medication as prescribed. About 190 participants who struggle with adherence will be randomly assigned to either the CAE program or standard care. T…

This study aimed to see if a lifestyle program called Lifestyle MIND could help people with serious mental illness manage or prevent type 2 diabetes. Participants would have been randomly assigned to join the program right away or wait. The study was withdrawn before any particip…

This pilot study tests a therapy called Narrative Enhancement and Cognitive Therapy (NECT-Y) to see if it can reduce self-stigma in youth aged 14-29 with bipolar disorder or multiple mental health conditions. About 96 participants will either join a 14-week virtual group therapy …

This study helps adults with schizophrenia, bipolar disorder, or other serious mental illnesses reduce or stop taking anticholinergic medications (like benztropine) when they are no longer needed. These drugs can cause memory problems and other side effects. The goal is to safely…

This study aimed to see if a sublingual film of dexmedetomidine (BXCL501) could quickly reduce agitation in adults with bipolar disorder or schizophrenia visiting the emergency department. It was a single-arm pilot study, but it was withdrawn before enrolling any participants. No…

This study tests a 6-session virtual program called Future Self-BD for people with bipolar disorder who want to quit smoking. Participants learn to vividly imagine positive future events that could happen if they stop smoking. The study aims to see if the program is acceptable an…

This study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a weaker electric current than standard electroconvulsive therapy (ECT), aiming to reduce side effects like memory problems. Eight adults aged 25-64 wi…

This study tests whether adding mindfulness-based therapy (MBT) to usual care helps adults with serious mental illness (like schizophrenia, bipolar disorder, or major depression) feel better and function better. Researchers will enroll 160 patients from a community mental health …

This study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. The program is led by a professional author and a mental health worker, and focuses on writing, sharing, …

This study is testing if adding supervised aerobic exercise to regular medication helps people with bipolar depression recover faster and prevents future episodes. It will enroll 54 participants who are currently experiencing depression. They will be randomly assigned to either d…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers will analyze DNA and health information from 4,185 adults aged 18 and older. The goal is to better understand the causes of bipolar disorder, not to test a new treatment.

This study looks at how low field magnetic stimulation changes brain activity in people aged 60 and older with bipolar depression. Forty participants will have brain scans before and after real or fake treatment on two separate days. The goal is to understand the brain effects of…

This study looks at how lithium, a common treatment for bipolar disorder, changes the brain's wiring. Researchers will use MRI scans to track brain connections in 120 people with bipolar depression over 26 weeks. The goal is to understand why lithium works, not to test a new trea…

This study tracks 126 adults with bipolar disorder over 18 months to see how the condition changes. Researchers collect blood, saliva, and brain scans to find biological markers linked to disease progression. The goal is to create a better system for predicting and treating bipol…

This study aims to collect DNA, brain images, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. By analyzing these samples and detailed clinical assessments, researchers hope to find phys…