Could a TB drug make brain zaps work better for depression?
NCT ID NCT05591677
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking D-cycloserine (a drug originally used for TB) before a non-invasive brain stimulation therapy called iTBS can improve depression symptoms more than the stimulation alone. About 180 adults with treatment-resistant depression will receive daily iTBS sessions for 4 weeks, along with either a low dose, high dose, or placebo of D-cycloserine. Researchers will track mood changes and side effects to see if the combination is safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
D-cycloserine
What this could lead to
If it works, this could point toward a more effective, drug-enhanced brain stimulation treatment for depression.
What could go wrong
This is a mid-stage trial with 180 participants, so results may not apply to everyone. The drug may cause side effects or not improve depression beyond the stimulation alone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Monash Alfred Psychiatry Research Centre
Melbourne, Victoria, 3004, Australia