Could a TB drug make brain zaps work better for depression?

NCT ID NCT05591677

Ongoing Symptom relief Sponsor: The Alfred Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking D-cycloserine (a drug originally used for TB) before a non-invasive brain stimulation therapy called iTBS can improve depression symptoms more than the stimulation alone. About 180 adults with treatment-resistant depression will receive daily iTBS sessions for 4 weeks, along with either a low dose, high dose, or placebo of D-cycloserine. Researchers will track mood changes and side effects to see if the combination is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: D-cycloserine
What this could lead to: If it works, this could point toward a more effective, drug-enhanced brain stimulation treatment for depression.
What could go wrong: This is a mid-stage trial with 180 participants, so results may not apply to everyone. The drug may cause side effects or not improve depression beyond the stimulation alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Monash Alfred Psychiatry Research Centre

Melbourne, Victoria, 3004, Australia

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