Could a TB drug make depression therapy work better?
NCT ID NCT05591677
First seen Jan 05, 2026 · Last updated May 06, 2026 · Updated 20 times
Summary
This study tests whether taking D-Cycloserine (a drug originally used for TB) before a non-invasive brain stimulation therapy called iTBS can improve depression symptoms more than the stimulation alone. About 180 adults with treatment-resistant depression will receive either a low dose, a higher dose, or a placebo before each daily session for 4 weeks. The goal is to see if the combination leads to greater symptom relief and is safe to use.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Monash Alfred Psychiatry Research Centre
Melbourne, Victoria, 3004, Australia
Conditions
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