Brain training boosts Ketamine's Mood-Lifting power?

NCT ID NCT06526078

ENROLLING_BY_INVITATION Symptom relief Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether short, computer-based cognitive training sessions can enhance or extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults with depression who are already receiving ketamine treatment. Participants will do either real cognitive exercises or sham exercises via a web app for 15-20 minutes per session. The goal is to see if this approach can make depression treatment more efficient and widely accessible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cognitive training exercises (behavioral intervention)
What this could lead to: If it works, this could make ketamine treatment for depression more effective and longer-lasting, helping people feel better faster.
What could go wrong: This is an early-stage study testing a new combination approach, so results may not be conclusive. The cognitive training is brief and self-administered, so adherence and real-world impact may vary.

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Conditions

The condition(s) this trial relates to.

bipolar disorder Depression depressive disorder dysthymic disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Kaiser Foundation Research Institute, a division of Kaiser Foundation Hospitals

Oakland, California, 94612, United States
University of Illinois at Chicago

Chicago, Illinois, 60612, United States

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