Brain training boosts Ketamine's Mood-Lifting power?
NCT ID NCT06526078
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether short, computer-based cognitive training sessions can enhance or extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults with depression who are already receiving ketamine treatment. Participants will do either real cognitive exercises or sham exercises via a web app for 15-20 minutes per session. The goal is to see if this approach can make depression treatment more efficient and widely accessible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cognitive training exercises (behavioral intervention)
What this could lead to
If it works, this could make ketamine treatment for depression more effective and longer-lasting, helping people feel better faster.
What could go wrong
This is an early-stage study testing a new combination approach, so results may not be conclusive. The cognitive training is brief and self-administered, so adherence and real-world impact may vary.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Kaiser Foundation Research Institute, a division of Kaiser Foundation Hospitals
Oakland, California, 94612, United States
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University of Illinois at Chicago
Chicago, Illinois, 60612, United States