Light-Based brain scanner may unlock secrets of depression and memory loss

NCT ID NCT06897670

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Mayo Clinic study uses a safe, noninvasive light-based device called fNIRS to measure brain activity in 200 adults with major depression, bipolar disorder, or mild cognitive impairment. By comparing brain blood flow patterns across these groups, researchers hope to better understand how these conditions affect the brain. Participants undergo a one-time brain scan and complete symptom questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify brain activity patterns linked to mood disorders and memory problems, potentially leading to better diagnosis or monitoring tools.
What could go wrong: This is an observational study, not a treatment trial. It is early-stage research focused on understanding, not curing or treating any condition. Results may not directly benefit participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder Cognitive Dysfunction major depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER MAJOR DEPRESSIVE DISORDER MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

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