Could a papaya supplement help aging skin hold onto moisture?
NCT ID NCT07725835
First seen Jul 24, 2026 · Last updated Aug 20, 2026 · Updated 2 times
Summary
This pilot study tests whether a daily fermented papaya supplement can improve skin barrier function in healthy adults aged 50 to 75. The main focus is on reducing water loss from the skin on the face, arms, and hands, measured with a non-invasive device. Participants take the supplement for 12 weeks and attend five visits over 20 weeks, including blood draws to check inflammation and blood sugar markers.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a fermented papaya dietary supplement called Immun'Age
- What this could lead to
- If it works, this could point toward a simple dietary supplement to support skin barrier health in aging skin.
- What could go wrong
- This is a small pilot study with only 30 participants, so results may not apply broadly. The supplement may have no measurable effect on skin hydration.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. 50-75 years 2. Willing to allow collection of 3 blood samples (Baseline, Week 12 and Week 20) 3. Willing to log daily compliance with FPP intake during the study period (12 weeks) 4. Absence of active systemic disease per investigator judgement. 5. No current use of immunosuppressant or immunomodulatory medications. 6. No active dermatological conditions at measurement sites that could impair measure, per investigator judgement. 7. Investigator determination of general good health. Exclusion Criteria: 1. Co-morbidity or concurrent medication that the Investigator deems impactful to patient safety or ability to adhere to FPP dosage. 2. Co-morbidity or concurrent medication that the Investigator deems confounding to outcome measure (i.e., topical or systemic steroid). 3. Current or history of allergy to FPP ingredients: Dextrose, Carica papaya, or Food yeast. 4. Concurrent participation in another interventional trial that may impact measures, per investigator judgement. 5. Uncontrolled diabetes (A1c \>7%). 6. Open wounds or actively receiving Wound Care services. 7. Pregnant or breastfeeding women. 8. Current use of warfarin.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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McGowan Institute for Regenerative Medicine
Pittsburgh, Pennsylvania, 15219, United States
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