Scientists hunt for genetic clues to biliary atresia, top cause of liver transplants in kids

NCT ID NCT03273049

Recruiting now Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study aims to uncover the genetic and developmental causes of biliary atresia, a rare condition that leads to liver failure in newborns and accounts for half of all childhood liver transplants worldwide. Researchers will analyze DNA from 1,100 children who have had or need a liver transplant due to biliary atresia. By identifying key genes and pathways, they hope to better understand why the disease occurs and potentially guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could uncover the genetic roots of biliary atresia, pointing toward better ways to diagnose or treat this rare liver disease in children.
What could go wrong: This is an observational study, not a treatment trial. It may not directly lead to new therapies, and findings might not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

biliary atresia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY ATRESIA

Contacts and locations

Locations

UPMC Children's Hospital of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

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