Scientists investigate the mystery of weight regain

NCT ID NCT05748158

Recruiting now Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at why people with obesity often regain weight after losing it through a behavioral weight loss program. About 205 adults aged 25-59 will first lose at least 7% of their body weight, then be followed for a year to track how much weight they regain. The goal is to understand the body's physiological changes that make weight maintenance difficult.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal why some people regain weight after dieting, pointing toward better strategies to maintain weight loss.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to any direct intervention, and results may not apply to everyone with obesity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Body-Weight Trajectory Obesity obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Drexel University
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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