Simple drug during surgery may stop chronic pain after breast cancer

NCT ID NCT04874038

Recruiting now Prevention Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large Phase 3 trial tests whether giving lidocaine (a numbing medicine) through an IV during breast cancer surgery can prevent persistent pain that often follows. Over 1,600 adults having lumpectomy or mastectomy will be randomly assigned to receive lidocaine or a placebo. The main goal is to see if fewer people develop pain 3 months after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lidocaine
What this could lead to: If it works, this could provide a simple, safe way to prevent long-term pain after breast cancer surgery.
What could go wrong: This is a large Phase 3 trial, but lidocaine is already widely used; the benefit may be small or not apply to all patients. Pain is complex and may not be fully prevented.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Chronic Pain chronic pain syndrome Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER PAIN, CHRONIC PAIN, POSTOPERATIVE POST-MASTECTOMY PAIN SYNDROME

Contacts and locations

Locations

B.P. Koirala Institute of Health Sciences
RECRUITING

Dharān, Nepal
Eastern Health- Health Sciences Centre
RECRUITING

St. John's, Newfoundland and Labrador, Canada
Foothills Medical Centre
RECRUITING

Calgary, Alberta, Canada
Humber River Hospital
RECRUITING

Toronto, Ontario, Canada
Hôpital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, Canada
IWK
RECRUITING

Halifax, Nova Scotia, Canada
Juravinski Hospital
RECRUITING

Hamilton, Ontario, Canada
Mount Sinai Hospital
RECRUITING

Toronto, Ontario, Canada
North York General Hospital
RECRUITING

North York, Ontario, Canada
Obafemi Awolowo University Teaching Hospitals Complex
RECRUITING

Ile-Ife, Nigeria
St. Michael's Hospital
RECRUITING

Toronto, Ontario, Canada
Sturgeon Community Hospital
RECRUITING

Edmonton, Alberta, Canada
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, Canada
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, Canada
Thunder Bay Regional Health Sciences Centre
RECRUITING

Thunder Bay, Ontario, Canada
University Health Network
RECRUITING

Toronto, Ontario, Canada
Women's College Hospital
RECRUITING

Toronto, Ontario, Canada

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