Corneal disorder

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This Phase 2 study tests atacicept, a drug that may reduce immune system attacks on the kidneys. About 250 adults with various autoimmune kidney diseases (like IgA nephropathy or membranous nephropathy) will receive weekly injections. Researchers will check safety and measure cha…

This study tests whether tofacitinib, a drug already used for rheumatoid arthritis, is safe and helpful for people with Sjogren's disease. About 60 adults with mild-to-moderate Sjogren's will take the pill twice daily for 28 weeks. Researchers will track side effects and measure …

This early study tests whether a patient's own urine-derived cells can be injected into the eye to repair damaged corneal cells. The trial enrolls just 3 people with corneal endothelial dysfunction, a condition that can cause pain and vision loss. The goal is to see if the cells …

This study compares two types of corneal transplants—PKP and DSAEK—in 334 adults aged 50+ with advanced bullous pseudophakic keratopathy, a condition where the cornea swells and blurs vision. Participants are randomly assigned to one procedure and followed for 2 years to see whic…

This study tests whether Miebo eye drops, used for one month before and 1.5 months after LASIK surgery, can reduce dry eye symptoms in people who already have dry eye disease. One hundred adults will use the drops four times daily. The goal is to see if eye dryness after surgery …

This study tests a two-step treatment for corneal neovascularization, where abnormal blood vessels grow on the clear front part of the eye. First, doctors use a fine needle with heat to seal off the vessels, then inject a drug called bevacizumab to prevent regrowth. The trial wil…

This study tests a prescription eye drop called Vevye (cyclosporine 0.1%) in 48 adults with meibomian gland dysfunction (MGD), a common cause of dry, burning eyes. Participants use the drops twice daily for 24 weeks, and researchers measure changes in eye symptoms, gland function…

This study tests whether adding cyclosporine A eye drops to standard natamycin treatment helps people with fungal keratitis (a serious eye infection). About 150 adults with confirmed fungal infection will receive either a low or high dose of cyclosporine A or a placebo for 4 week…

This study tests whether it is safe and possible to perform corneal cross-linking on both eyes on the same day in people with keratoconus, a condition where the cornea thins and bulges. Fifteen participants will receive riboflavin eye drops and UV-A light treatment in both eyes a…

This study tests a single injection of AURN001 in 120 adults with corneal swelling caused by endothelial dysfunction. The goal is to see if it improves vision and reduces corneal thickness compared to a placebo. Participants must already have an artificial lens in the eye and be …

This study tests a temporary magnetic device designed to help people with paralytic lagophthalmos—a condition where the eyelid cannot close fully—protect their eyes from dryness, ulcers, and vision loss. The device uses small magnets placed on the eyelids to gently hold them shut…

This early-stage trial tests an investigational drug called ABBV-319 in 36 adults with lupus or Sjogren's disease. The drug is designed to deplete overactive B cells, which are part of the immune system that cause inflammation and symptoms. Participants receive two doses by IV, 2…

This study tests an oral drug called sparsentan in 67 children with certain kidney diseases that cause protein to leak into urine. The goal is to see if the drug safely reduces protein levels over 108 weeks. Participants must have a certain level of kidney function to join.

This study compares two surgical approaches for Fuchs endothelial dystrophy, a condition that clouds the cornea. One is a full corneal transplant (DMEK), the other is a simpler procedure that removes only the diseased cells (DSO) plus Ripasudil eye drops to help healing. 60 parti…

This Phase 3 trial tests whether adding steroid eye drops to standard anti-parasitic treatment improves vision in people with acanthamoeba keratitis, a rare but serious eye infection. About 232 participants who still have eye inflammation after one month of standard care will rec…

This early-stage trial is testing an experimental eye drop called CSB-001 in 75 people with limbal stem cell deficiency, a condition where the eye's surface can't heal properly, leading to pain and vision loss. The study will check if the drops are safe and if they help improve s…

This study tests whether adding diquafosol eye drops to standard treatment helps people with moderate-to-severe vernal keratoconjunctivitis (a serious eye allergy). About 94 participants aged 6 and older will receive either diquafosol plus cyclosporine or cyclosporine alone. Rese…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study tests whether briefly soaking a donor cornea in a solution made from the patient's own blood (PRGF) before transplant surgery can reduce the loss of important cells after the operation. About 100 people with Fuchs' endothelial dystrophy or corneal swelling will take pa…

This study tests INTACS prescription inserts, small plastic implants placed in the cornea, to reduce astigmatism and improve vision in people with keratoconus. The goal is to help patients who can no longer see well with glasses or contacts and may otherwise need a corneal transp…

This study compares two types of cornea transplant surgery—DSAEK and DMEK—in 220 adults with corneal swelling or Fuchs' dystrophy. The goal is to see which procedure leads to better vision and patient satisfaction one year after surgery. Participants will be randomly assigned to …

This Phase 2 trial tests whether Lacripep eye drops can help the cornea heal faster and more smoothly after PRK laser eye surgery. 88 active-duty military members and their dependents will receive Lacripep in one eye and a placebo in the other. The study measures corneal thicknes…

This program provides access to BRM421 eye drops for adults with mild to moderate limbal stem cell deficiency (LSCD), a condition that can cause vision problems. Participants use the drops twice daily for at least 12 weeks and have monthly checkups. The goal is to see if this tre…

This study tests whether stingless bee honey (Kelulut honey) can help young people with juvenile open-angle glaucoma. Sixty participants will either take 30 grams of honey daily for three months or receive no honey. Researchers will measure changes in inflammation, eye nerve thic…

This Phase 2 trial tests whether GLK-221 eye drops can safely slow the progression of keratoconus, a condition that thins and bulges the cornea. About 100 adults with keratoconus will use the drops twice daily for several months. The main goal is to see if the drops reduce the st…

This study tests whether injecting the antibiotic moxifloxacin directly into the cornea can help treat bacterial eye infections that don't improve with standard antibiotic drops. About 60 adults with stubborn corneal infections will receive either the injection plus drops or drop…

This phase 3 trial tests whether a shorter 18-minute ultraviolet (UVA) light exposure works as well as the standard 24-minute exposure during corneal crosslinking for keratoconus and similar conditions. The treatment uses riboflavin (vitamin B2) eye drops followed by UVA light to…

This Phase 3 trial tests a treatment called corneal crosslinking (CXL) for people with Down syndrome who have keratoconus, a condition where the cornea thins and bulges, blurring vision. The procedure uses vitamin B2 eye drops and ultraviolet light to strengthen the cornea. Resea…

This study tests whether combining a laser vision correction (PRK) with corneal cross-linking improves eyesight and corneal shape better than cross-linking alone in people with keratoconus, a condition that thins and bulges the cornea. Fifty adults aged 18-40 with mild to moderat…

This study tests a new way to treat a detached Descemet's membrane, a rare complication after cataract surgery. Fifty patients aged 50-70 will be split into two groups: one gets a standard air injection into the eye, and the other gets a modified technique that first deflates the…

This early study tests a tiny, permanent metal mesh (nitinol) implant placed inside the cornea to stabilize the eye and improve vision in people with advanced keratoconus. The trial involves 12 adults who are not candidates for other treatments and are currently recommended for a…

This study tests a new surgical method for pterygium, a growth on the eye's surface. Instead of cutting the growth out completely, surgeons move it to a different spot and stitch it down, preserving healthy tissue. The goal is to see if this lowers the chance of the pterygium com…

This study tests a new device called the Gebauer Lenticule, a tiny implant made from pig collagen, for people with severe keratoconus or post-LASIK ectasia. The implant is placed inside the cornea to strengthen it and improve stability, potentially delaying or avoiding the need f…

This early-stage trial tests a new implant called PVEK for people with corneal swelling from Fuchs' dystrophy or pseudophakic bullous keratopathy. The implant uses a collagen scaffold with human corneal cells to replace damaged tissue. About 15 participants will receive the impla…

This study tests whether injecting anti-VEGF medication directly into the cornea can safely reduce abnormal blood vessel growth caused by herpes simplex keratitis. One hundred adults will receive either the injection plus antiviral eye drops or standard antiviral drops alone. Res…

This study tests an experimental eye drop called DT-168 in people with Fuchs endothelial corneal dystrophy who are already scheduled for a corneal transplant. The goal is to see if the drops are safe and affect disease-related markers. About 28 adults aged 30 and older with a spe…

This study tests whether transplanting healthy bacteria from the eye's surface can help people with moderate to severe dry eye. Forty participants will either receive the bacteria transplant or a fake procedure. Researchers will measure changes in eye discomfort and surface damag…

This study tests whether injecting stem cells into the eye can help heal corneal ulcers that haven't improved with standard treatments. The stem cells are donated from healthy volunteers and processed in a lab. About 38 adults with persistent eye surface damage will receive the i…

This study tests a new treatment for people who have lost vision in both eyes due to severe burns or rare eye diseases. Doctors take a small sample of cells from the inside of the patient's cheek, grow them into a thin sheet in the lab, and then transplant that sheet onto the dam…

This early-stage trial tests the safety of injecting special human cells (EO2002) into the eye to treat corneal swelling. Twelve adults with corneal edema from Fuchs' dystrophy or after cataract surgery will receive multiple injections, with or without Ripasudil eye drops. The ma…

This study looks at how safe and effective DMEK (a type of cornea transplant) is for people who have already had eye surgeries like vitrectomy or glaucoma surgery. Researchers will track serious complications and vision improvement over 12 months in 80 participants. The goal is t…

This study tests a device that uses riboflavin (vitamin B2) drops and UV light to stiffen the cornea, the clear front part of the eye. It is for people with keratoconus or similar conditions that cause the cornea to bulge and blur vision. The goal is to see if the treatment safel…

This study tests a new, gentler steroid eye drop plan after corneal transplant surgery. The goal is to prevent rejection while reducing side effects like high eye pressure. About 342 adults getting a DMEK transplant will be followed for two years to see if a milder steroid works …

This phase 2 trial is testing whether N-acetyl cysteine (NAC) eye drops can reduce oxidative stress in the eyes of people with Fuchs endothelial corneal dystrophy (FECD), a condition that often leads to corneal transplant. The study will enroll 45 adults with advanced FECD who ar…

This study tests special eye drops made with stem cells to see if they can help people with dry eye disease and cataracts. Researchers will give 300 adults these drops three times a day for 12 weeks. They will check if the drops improve tear film, reduce symptoms, and clear up th…

This early-stage trial tests a new type of corneal graft made from lab-grown human cells. It is for people with mild to moderate corneal damage from conditions like Fuchs' dystrophy or after eye surgery. The goal is to see if the graft is safe and can improve vision. 30 participa…

This study tests a laser-guided procedure to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The procedure uses OCT scans to plan a custom laser treatment that smooths the cornea and strengthens it with cross-linking. Researchers aim to se…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study tests a new AI algorithm that screens for severe dry eye disease by analyzing images of the cornea. Researchers will enroll 200 adults already diagnosed with dry eye to see if the AI can better identify cases needing specialist care compared to a standard symptom quest…

This study is testing a new eye imaging device called the VG200D, which uses advanced technology to take detailed pictures of the eye. Researchers want to see if it works as well as a standard device for measuring parts of the eye in people with glaucoma, retina problems, corneal…

This study is testing a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of 168 volunteers, including healthy people and those with keratoconus or post-LASIK ectasia, t…

This study is testing advanced lab techniques, like genetic sequencing and multiplex PCR, to improve how doctors diagnose complex eye infections such as endophthalmitis and severe corneal abscesses. Researchers will compare the new methods to standard cultures to see if they find…

This study aims to improve how doctors detect, classify, and treat irregular corneas caused by conditions like keratoconus, dry eye, and corneal scars. Researchers will use a special imaging device called optical coherence tomography (OCT) to get detailed measurements of the corn…

This study tests a new eye drop called HUC1-394 in 150 adults with moderate to severe dry eye disease. Participants will use the drops or a placebo for a period to see if the drug reduces eye surface damage and improves symptoms. The goal is to find the best dose and frequency.

This study compares three different over-the-counter lubricating eye drops in people with dry eye disease. Researchers will measure how well each drop is tolerated, how much it improves symptoms like discomfort and blurry vision, and its effect on daily visual function. The trial…

This study tests a new eye drop called DFL24498 in people with dry eye disease. About 417 adults will use the drops four times a day for 12 weeks. Researchers will check if the drops improve eye surface health and reduce dryness symptoms compared to a placebo.

This study tests whether a protein-based eye drop (rhPRG4) can safely relieve dry eye symptoms in people with Sjögren's syndrome. About 80 adults will receive either the active drops or a placebo for 28 days. The main goal is to see if the drops can clear corneal staining, a sign…

This study is testing two versions of Tears Naturale lubricating eye drops—one with preservatives and one without—in 120 people with mild to moderate dry eye disease. Participants will stop using their usual artificial tears and use only the study drops for the duration of the tr…

This early study tests eye drops made from stem cell particles in 20 adults with dry eye disease. Participants use the drops four times daily for four weeks. Researchers track safety and symptom changes like eye staining and tear film stability.

This study tests whether a new eye drop, BUFY01, works as well as an existing one, SVS20, for people with dry eye disease. About 80 participants will use one of the two drops daily for three months. Researchers will check eye health and ask about symptoms to see if the treatments…

This study tests whether a new treatment (BUFY02) works as well as an existing one (TRB02) for dry eye disease. About 80 adults with dry eye for at least 3 months will use the assigned eye drops daily for 3 months. Researchers will check eye health and symptoms to see if both tre…

This early study tests a new spring made from surgical stitches to help people with facial nerve palsy close their eyelid. The spring is placed under the skin near the eyelid center, without attaching to bone. Ten adults who cannot blink due to nerve damage will try it, aiming to…

This study tests whether rinsing the inner eyelids and eye surface with a special device can lower inflammation and improve symptoms in people with dry eye disease. Researchers will measure changes in a marker of inflammation called MMP-9 in 33 participants. The goal is to see if…

This study tests whether licaminlimab eye drops can reduce eye discomfort in people with dry eye disease who have a specific gene variant. About 160 participants will use the drops three times daily for 29 days. The goal is to see if this targeted approach works better than a pla…

This study tests a varenicline nasal spray for treating dry eye and meibomian gland dysfunction. Researchers will measure changes in tear film thickness and stability in 65 adults with mild to moderate symptoms. The goal is to see if the spray improves eye comfort and gland funct…

This study tests a new lubricating eye drop called ABR2 in 40 adults with dry eye syndrome. The goal is to check if the drop is safe and tolerable when used for up to 28 days. Participants first receive a single drop in one eye, then use the drop at least twice daily for a month.…

This study compares two preservative-free eye drops, Artelac Complete MDO and VISMED MULTI, for treating moderate to severe dry eye disease. About 160 adults who have used tear substitutes for at least a month will use one of the two drops for 90 days. Researchers will measure ch…

This study tests a disposable silicone device that clips onto eyeglasses to trap moisture around the eyes. Thirty-five adults with mild to moderate dry eye will wear it for two hours. Researchers will measure tear film stability, tear volume, and symptom changes before and after …

This study compares a clinic-based thermal device (MiBo Thermoflo) to standard warm compresses for treating dry eye caused by meibomian gland dysfunction. About 42 adults who haven't improved with warm compresses will be randomly assigned to either three sessions of MiBo therapy …

This study is testing VEVYE eye drops (cyclosporine 0.1%) in 50 adults with dry eye disease who also have a neuro-ophthalmic condition, such as neurotrophic keratitis. Participants use the drops twice daily for 6 months. Researchers will measure changes in corneal staining and sy…

This study tests whether eye drops made from cord blood plasma can reduce pain in people with long-term nerve-related eye pain. Twenty adults with persistent eye pain and abnormal corneal nerves will receive the drops. Researchers will measure pain levels and nerve health to see …

This study tests whether placing a tiny plug in the upper tear duct can further relieve dry eye symptoms in people who already have a plug in the lower tear duct. Researchers will follow 36 adults with aqueous-deficient dry eye for 6 months, measuring eye comfort and tear film ch…

This study tests whether a special ingredient called trehalose, found in some artificial tears, can improve the eye's natural barrier function in people with dry eye disease. About 30 adults with moderate-to-severe dry eye will use the drops for one month. Researchers will measur…

This trial tests whether a non-invasive radiofrequency device (Thermage FLX) plus eyelid gland expression can improve tear film stability better than gland expression alone in people with dry eye that hasn't responded to standard treatments. About 112 adults with moderate to seve…

This study compares two lubricating eye drops—Systane PRO PF and Thealoz Duo—to see which one better relieves dry eye symptoms. About 100 adults with dry eye will use each drop for 4 weeks, one twice a day and the other four times a day. The goal is to find out if they work equal…

This study looks at whether Systane COMPLETE artificial tears can improve dry eye symptoms and help doctors better predict cataract surgery outcomes. About 140 cataract patients with dry eye will use the drops before and after surgery. Researchers will measure changes in eye shap…

This study tests whether using Systane COMPLETE eye drops before cataract surgery can improve dry eye symptoms and help with surgical planning. About 150 adults aged 20-85 with dry eye who need cataract surgery will use the drops regularly before their operation. Researchers will…

This study tests whether a product called Lacrifill can help people who wear contact lenses but get dry, uncomfortable eyes. About 30 adults who currently can't wear their lenses for long periods will use Lacrifill for 2-3 months. Researchers will check if it improves comfort, ex…

This study compares two eye drops—SYSTANE PRO and MIEBO—to see if SYSTANE PRO works as well as MIEBO for treating dry eye disease. About 260 adults with moderate dry eye will use one of the two drops for one month. The main goal is to measure changes in dry eye symptoms using a s…

This study is testing two new artificial tear formulas to see if they are safe and well-tolerated in people with moderate dry eye disease. Researchers will monitor for side effects and eye health in 148 participants who already use artificial tears. The goal is to find better opt…

This Phase 2 trial tests a new eye drop that combines two active ingredients—lifitegrast and perfluorohexyloctane—for people with dry eye disease. About 423 adults will use the drops twice daily for 4 weeks. Researchers will measure changes in eye surface staining and symptom sco…

This study tests a new eye drop (FBV_01) that combines an extra ingredient with hyaluronic acid for people with moderate-to-severe dry eye. About 74 adults will use the drop four times a day for 30 days. Researchers will compare it to hyaluronic acid alone to see if the combo is …

This study tests whether a standard cosmetic treatment for eye wrinkles (Tixel) can also improve symptoms and signs of dry eye disease. 36 adults with mild to moderate wrinkles and dry eyes will receive either real Tixel or a sham treatment. The goal is to see if the treatment is…

This study looks at whether lifestyle changes can improve dry eyes in obese women with polycystic ovary syndrome (PCOS). Researchers will measure tear production and eye comfort in 40 women before and after the program. The goal is to see if weight loss and healthy habits can eas…

This study tests whether TheaLoz Duo eyedrops can protect the eyes of people who play handheld console or computer games for at least 2 hours daily. 28 participants with mild dry eye symptoms will use the drops for one month and no drops for another month, in random order. Resear…

This study tests an experimental eye drop (rhPRG4) to see if it safely eases dry eye symptoms in people with ocular graft-versus-host disease (oGVHD), a complication after bone marrow transplant. About 15 adults with moderate to severe dry eye will receive both the active drop an…

This study compares red and blue light therapy masks for people with dry eye disease, meibomian gland dysfunction, and blepharitis (eyelid inflammation). Thirty-six participants will receive three light treatments, one week apart, and be followed for one month after the last sess…

This study tests whether Vit-A-Vision, an eye ointment used up to three times daily, can improve dry eye symptoms like burning and irritation. About 77 adults with dry eye disease will use the ointment for 30 days. Researchers will measure tear film stability and symptom scores t…

This study is testing whether eye drops made from a patient's own blood serum can safely relieve symptoms of moderate-to-severe dry eye that hasn't improved with artificial tears. Researchers will collect a blood sample from each of the 70 participants, process it into drops, and…

This study tests whether a drug called TRYPTYR (Acoltremon) can improve quality of life and work ability in adults with chronic dry eye disease. About 40 participants who are unhappy with their current treatment will use the eye drops for one month. Researchers will measure chang…

This early study tests a new eye drop called JN002 in 30 adults with dry eye disease. Participants will use the drops three times a day for 28 days. The goal is to see if the drops are safe and if they improve symptoms and eye surface health compared to a placebo.

This study compares two stitching methods used during surgery for pterygium, a growth on the eye's surface. Forty people with primary pterygium will be randomly assigned to receive either a new compression continuous suture or the traditional suture technique. The goal is to see …

This study is testing a new eye drop that combines trehalose, sodium hyaluronate, and NAAGA without preservatives. It will enroll 30 adults with dry eye disease who are either new to treatment or unhappy with their current drops. Over 6 months, researchers will track changes in s…

This study tests a gel placed in the tear ducts before cataract surgery to see if it helps dry eye symptoms. Sixty adults with dry eye will receive the gel and be followed for up to 5 months. The main goal is to measure tear film stability, a key sign of eye moisture.

This study tests a device called Rexon-Eye that uses low-level electrical current to treat dry eye disease. Researchers will also analyze tear proteins to see how they change with treatment. The trial involves 75 adults with dry eye and aims to understand both the device's effect…

This study tests whether a new eye drop called VSJ-110 can safely ease dry eye symptoms. About 160 adults will use either the active drops or a placebo for eight weeks. Researchers will check for changes in eye surface damage, tear production, and discomfort.

This study tests whether Kera Sol eye drops can reduce dry eye symptoms in the two weeks after LASIK surgery. About 60 adults having LASIK in both eyes will use the drops and be monitored for changes in corneal staining and comfort. The goal is to see if the drops help manage tem…

This study is testing whether eye drops made from cord blood plasma can relieve symptoms of moderate to severe dry eye disease better than standard artificial tears. Researchers will compare the cord blood drops combined with cyclosporine to a control treatment of hyaluronic acid…

This study looks at whether a new cyclosporin eye drop (Vevizye®) can reduce inflammation and dryness in people with moderate to severe dry eye disease who still have symptoms after using artificial tears. About 25 adults with chronic dry eye and visible eye redness will use the …

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study will compare how well patients see after three types of corneal transplants: DSAEK, UT-DSAEK, and DMEK. Researchers will follow 1,000 people who had surgery for Fuchs' endothelial corneal dystrophy or pseudophakic bullous keratopathy. They will measure vision, cell cou…

This study looks at whether dry eye disease affects the accuracy of corneal measurements needed for cataract surgery planning. 400 cataract patients will be divided into those with and without dry eye. Those with dry eye will use sodium hyaluronate eye drops for two weeks. Resear…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study is for people with rare kidney diseases like Minimal Change Disease, Focal Segmental Glomerulosclerosis, and Membranous Nephropathy. Researchers will collect health information and biological samples from 1,200 participants over many years. The goal is to better unders…

This study helps people with certain kidney diseases (like nephrotic syndrome and FSGS) find clinical trials that match their specific disease profile. Researchers analyze participants' molecular data to recommend targeted therapies in ongoing trials. The goal is to improve treat…

This study aims to collect DNA samples and detailed eye exam data from 1,000 people with rare inherited eye diseases like aniridia, Best disease, and albinism. Participants provide a saliva or blood sample and share their eye health records. The goal is to expand a research repos…

This study watches 500 people with limbal stem cell deficiency (LSCD) to see how the disease changes over time. Researchers will track vision, eye comfort, and physical eye changes using questionnaires and tests. No new treatments are given—the goal is simply to learn more about …

This early-stage study is testing a new oral drug called SK-09 in 72 healthy adults to see if it is safe and how the body processes it. The study is split into two parts: one where participants get a single dose, and another where they get multiple doses. No one knows who gets th…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study looks at whether polishing the inner layer of the cornea before injecting new cells helps remove tiny bumps called guttae in people with Fuchs endothelial corneal dystrophy. Twenty adults scheduled for corneal transplant will have half their cornea polished and the oth…

This study will enroll 50 people with dry eye disease to compare three different devices that measure the thickness of the tear film's lipid layer. Researchers want to see which device gives the most consistent readings and which one best matches other signs of dry eye. The goal …

This study looks at whether sending SMS reminders can improve how often patients with corneal ulcers come back for follow-up visits at an eye hospital in Nepal. About 310 adults aged 18 to 70 who own a mobile phone will take part. The goal is to see if a simple text message can h…

This study looks at what happens to the front part of the eye (the cornea) right after smoking a cigarette. Researchers will measure changes in corneal thickness and clarity in 90 healthy adults, comparing smokers to non-smokers. The goal is to understand if smoking causes immedi…

This study is looking at how genes relate to the different forms of Fuchs corneal endothelial dystrophy, a common eye disease that affects the cornea. Researchers in France will enroll 500 people who need corneal transplant surgery. They will analyze blood samples for genetic mar…

This study will test whether 0.1% cyclosporine A eye drops can change the number and behavior of immune cells on the eye's surface in people with dry eye disease. Researchers will use a special microscope to watch these cells move over 12 weeks and compare the drops to a lubricat…

This study is collecting medical information and biological samples (like blood, urine, and kidney tissue) from 300 people with FSGS or MCD who have had or will have a kidney transplant. The goal is to build a research biobank called RESOLVE to help scientists study why these dis…

This study follows thousands of people with keratoconus, a condition that makes the cornea thin and bulge. Researchers measure the eye's shape and vision over many years to understand how the disease starts and changes. No new treatments are tested—the goal is simply to learn mor…

This study collects tear samples from 300 people with dry eye, infectious keratoconjunctivitis, mucous membrane pemphigoid, or allergic conjunctivitis. Researchers will analyze the proteins and metabolites in tears to create a unique fingerprint for each condition. The goal is to…

This long-term study collects data from over 100 eye clinics in Germany to see how corneal transplant surgeries have changed since 2001. Researchers track the number of surgeries, the types of procedures used, and the reasons people need them. The goal is to understand trends, no…

This study collects information and biological samples from 150 adults who have had cancer therapy and now have eye complications, such as dry eye or graft-versus-host disease. Researchers will track their eye health over time using standard exams and lab tests. The goal is to le…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study is a global registry for people with Castleman disease, a rare lymph node disorder. Researchers will collect medical records, lab results, and patient surveys from up to 1,000 participants to better understand symptoms, treatments, and outcomes. No experimental drug or…

This study follows 800 children born with eye malformations like microphthalmia, anophthalmia, aniridia, or anterior segment defects. Researchers will track their vision, brain development, and overall health for up to 10 years to better predict outcomes. No new treatments are be…

This study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …

This study looks at whether the amount of iron in tears is linked to how severe dry eye disease is. Researchers will collect tear samples from 52 people with and without dry eye and compare iron levels to standard eye tests and symptom scores. The goal is to find a new way to dia…

This study collects eye fluid, cells, and blood samples from 150 adult cancer patients who have dry eye disease after a stem cell transplant (graft-versus-host disease). Researchers will analyze these samples to find risk factors, markers, and possible treatment targets. The goal…

This study compares lying on your back for 1 day versus 5 days after a specific type of corneal transplant (DMEK) for Fuchs dystrophy. Researchers want to see if a longer period helps the transplant stay attached and reduces the need for extra procedures. About 102 participants w…

This study aims to understand the natural bacteria living on the surface of the eye in both healthy people and those with certain eye conditions. Researchers will collect eye swabs from 500 adults in middle Tennessee to build a database of what a normal eye microbiome looks like.…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study looks at how low-level light therapy changes tear proteins in people with dry eye disease. Researchers want to understand how the therapy works and find markers that show who will respond well. About 30 adults will have their tears tested before and after treatment.

This study looks at how to better diagnose and treat dry eye before cataract surgery to help people see better after the operation. About 110 adults with dry eye will be followed to find the best ways to prepare the eye surface. The goal is to create clear guidelines that eye doc…

This study looks at whether closing your eyes for 3 minutes can improve the quality of a key eye measurement (keratometry) used before cataract surgery. The measurement is often less accurate in people with dry eye. Researchers will compare measurements taken before and after eye…

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

This study is looking at tiny changes on the surface of eye cells in people with severe dry eye. Researchers will compare these cells before and after treatment starts, and also compare them to people without dry eye. The goal is to better understand what happens in the disease, …

This study is testing a scoring system called the SUCCESS Score to see if it can predict which people with Fuchs dystrophy will need a cornea transplant after cataract surgery. Researchers will follow 250 adults who have both Fuchs dystrophy and cataracts. The goal is to improve …

This study is looking at 60 people with a genetic eye surface disease called limbal stem cell deficiency. Researchers want to find out if certain gene changes are linked to more severe disease. They will compare patients' genes with their eye health to look for patterns. This is …

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…

This pilot study explores whether people with dry eye disease can complete surveys and collect eye fluid samples from home, instead of visiting a clinic. Researchers aim to see if this remote method is practical and can help include more diverse participants in future studies. 90…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study involves 135 adults getting a cornea transplant. Surgeons will use a new method to check the health of donor eye tissue before surgery. The goal is to see if this check helps predict how well the transplant will work long-term, reducing the chance of graft failure.

This study looks at whether using eyeliner can lead to dry eyes. Researchers will compare tear production, tear film stability, and tear composition between 80 people who use eyeliner regularly and those who don't. The goal is to understand if eyeliner ingredients change tears an…

This study tests two different preparation designs (bevel vs. butt) for Peek endocrowns, which are tooth-colored caps for molars that have had root canals. Researchers will check how precisely each design fits the tooth, using a replica technique and microscope. The goal is to se…

This registry is gathering health information and biological samples from 500 people with focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD), two rare kidney conditions. Researchers will track participants over 10 years to understand how these diseases prog…

This study looks at whether low-level light therapy (LLLT) warms the eyelids differently in people with various skin pigmentation levels who also have dry eye or meibomian gland disease. Forty adults will receive three 15-minute sessions over 1-2 weeks. Researchers will measure e…

This study is collecting blood and joint fluid samples from 300 children and young adults with juvenile idiopathic arthritis (JIA) to see if certain markers can predict how severe the disease will become. Researchers will track participants' symptoms, treatments, and joint damage…

This pilot study is testing whether a non-contact imaging technique called Brillouin microscopy can measure corneal stiffness in people with glaucoma. Researchers will compare these measurements between patients with high-tension glaucoma, normal-tension glaucoma, and healthy con…

This study is testing whether a special eye scanner (OCT) can help fit scleral contact lenses more accurately than the usual method. Researchers will enroll 258 people with conditions like keratoconus or scarred corneas. Each participant will have lenses fitted both the standard …

This study uses a special eye scan called OCT to measure swelling in the cornea of people with Fuchs' dystrophy or a related condition. Researchers want to see if this scan can predict how vision changes after surgery. About 60 participants will be observed over time.

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, over two years. Researchers will track changes in vision, corneal shape, and thickness, and analyze tear proteins to better understand how the disease progresses. Some participants will …