Light-Based eye test could spot glaucoma risk early
NCT ID NCT06993597
First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times
Summary
This pilot study is testing whether a non-contact imaging technique called Brillouin microscopy can measure corneal stiffness in people with glaucoma. Researchers will compare these measurements between patients with high-tension glaucoma, normal-tension glaucoma, and healthy controls. The goal is to see if corneal stiffness can serve as a biomarker to predict glaucoma risk and progression. The study involves 60 participants and will also track changes after standard pressure-lowering eye drops.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Brillouin microscopy (non-contact imaging device)
- What this could lead to
- If successful, this could lead to a new way to assess glaucoma risk and track disease progression using a simple, non-invasive eye scan.
- What could go wrong
- This is a small, early-stage pilot study with only 60 participants. The measurements may not reliably predict glaucoma outcomes, and more research will be needed.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Maryland School of Medicine
RECRUITINGBaltimore, Maryland, 21201-1757, United States
Contact Email: •••••@•••••
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