Light-Based eye test could spot glaucoma risk early

NCT ID NCT06993597

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This pilot study is testing whether a non-contact imaging technique called Brillouin microscopy can measure corneal stiffness in people with glaucoma. Researchers will compare these measurements between patients with high-tension glaucoma, normal-tension glaucoma, and healthy controls. The goal is to see if corneal stiffness can serve as a biomarker to predict glaucoma risk and progression. The study involves 60 participants and will also track changes after standard pressure-lowering eye drops.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Brillouin microscopy (non-contact imaging device)
What this could lead to
If successful, this could lead to a new way to assess glaucoma risk and track disease progression using a simple, non-invasive eye scan.
What could go wrong
This is a small, early-stage pilot study with only 60 participants. The measurements may not reliably predict glaucoma outcomes, and more research will be needed.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Maryland School of Medicine

    RECRUITING

    Baltimore, Maryland, 21201-1757, United States

    Contact Email: •••••@•••••

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