GLAUCOMA

This study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…

This study tests a tiny implant called MINIject s+ to help drain fluid and lower eye pressure in people with open-angle glaucoma. About 60 adults will receive the implant during surgery, and researchers will check if it is placed correctly and is easy for surgeons to use. The goa…

This study looks at whether adding a combination of two eye drops (netarsudil and latanoprost) after laser treatment works better than adding just one drop (latanoprost) for lowering eye pressure in people with glaucoma. About 36 adults with mild to moderate glaucoma will take pa…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) done at the same time as cataract surgery. About 243 adults with mild to moderate open-angle glaucoma will take part. The goal is to see which surgery lowers ey…

This Phase 3 trial tests a second-generation implant placed inside the eye that slowly releases travoprost, a drug that lowers eye pressure. The study will enroll 510 adults with open-angle glaucoma or high eye pressure. The goal is to see if the implant is safe and effective at …

This study is testing a special laser called ELIOS to treat glaucoma at the same time as cataract surgery. The laser creates tiny channels in the eye to help fluid drain and lower eye pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal i…

This study tests whether a weak electrical current applied to the eye's surface can improve vision in people with open-angle glaucoma. Fifty adults with worsening vision loss will receive either real or sham stimulation over several sessions. The goal is to see if this safe, non-…

This study follows 200 glaucoma patients who received a tiny eye implant called Hydrus along with cataract surgery. Researchers want to see if the implant still helps control eye pressure after 8 to 14 years. The goal is to understand how well the implant works over the long term…

This study tests a modified surgical procedure to lower eye pressure in 20 glaucoma patients whose previous combined cataract and glaucoma surgery did not work well. The surgery avoids a certain eye layer to improve success. The main goal is to see if it safely reduces eye pressu…

This study tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 610 participants will receive either the implant, timolol eye drops, a sham procedure, or placebo drops. The main goal …

This study tests whether a gentle electrical current applied to the brain (called rtACS) can wake up damaged eye cells and improve vision in people with glaucoma. 188 adults with moderate to advanced glaucoma will receive either real or sham stimulation for 10 days. The main goal…

This study tests a small device called iStent that is placed in the eye during cataract surgery to help lower pressure in people with open-angle glaucoma. Sixty adults with both glaucoma and cataracts will be enrolled. The goal is to see if the iStent is safe and effective at red…

This study tests whether a daily supplement called BrudyGlauco (containing DHA and citicoline) can help protect eyesight in people with glaucoma. About 108 participants will take either the supplement or a placebo for 12 months. The goal is to see if it slows vision loss and impr…

This study tests whether metformin, a drug used for diabetes, can protect the optic nerve and slow vision loss in people with glaucoma. 125 participants with worsening glaucoma will take either metformin or a placebo for 24 months. The goal is to see if metformin can slow the thi…

This study tests whether adding pilocarpine eye drops after combined cataract and Kahook Dual Blade surgery helps lower eye pressure more than standard drops alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients achieve a 2…

This study tests whether a device called Eyetronic, which delivers mild electrical pulses through the eyes, can help people with glaucoma. Glaucoma damages the optic nerve and can lead to vision loss. The trial will compare the active device to a sham (fake) version in 30 adults …

This phase 3 trial tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant with a special lens or standard eye drops. The goal is to see if…

This study tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant plus a special lens or standard eye drops. The goal is to see if the imp…

This pilot study tests a new, portable device called the World Sight Foundation Field Machine (WSFFM) for measuring visual field loss in glaucoma patients. The WSFFM is compared to the standard Humphrey Visual Field analyzer to see if it can accurately detect glaucoma damage. If …

This study is testing a new device called TonoVera to see how well it measures pressure inside the eye compared to current methods. Researchers will enroll 300 adults with glaucoma. The goal is to find out if the new tool is accurate enough for routine use.

This study tests a new smart contact lens that measures eye pressure continuously for 24 hours, compared to standard spot checks. It involves 12 adults with glaucoma or high eye pressure. The goal is to see if the lens provides accurate readings day and night, which could lead to…

This study tests a special camera that takes detailed images of the retina using many wavelengths of light. Researchers hope it can find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in Melbourne, Austral…

This study tests whether using telehealth tools like eye scans and pressure checks can find undiagnosed glaucoma earlier than just giving people information. It includes 2,000 Black and Hispanic adults and people with diabetes who are at higher risk. The goal is to see if remote …

This pilot study tests a new handheld OCT device that automatically aligns to the eye to take detailed pictures of the retina. Researchers will scan 50 healthy adults, adult patients, and children in eye clinics to see if the device works well. The goal is to make retinal imaging…

This study tests a new device that uses special 'structured light' patterns to see if people with age-related macular degeneration (AMD) perceive them differently than those with healthy vision. The goal is to develop a test that can detect AMD earlier than current methods, befor…

This study compares two new investigational devices for measuring eye pressure against the current standard methods in 200 adults with glaucoma or suspected glaucoma. The goal is to find a more objective, reproducible, and portable way to measure eye pressure. Participants will h…

This study tests whether an artificial intelligence (AI) program can help spot glaucoma, a leading cause of blindness, in people with diabetes. About 1,040 adults with diabetes will have their eye photos checked by either the AI or a human grader to see which method finds glaucom…

This study is testing whether an AI-based eye screening program can help detect glaucoma and other eye conditions in people visiting community health centers. About 1,800 adults at higher risk for glaucoma will get a quick eye scan using an AI tool called AI-RONA. If the screenin…

This study compares a technology-enhanced eye exam to a standard optometric exam for detecting three leading causes of blindness: glaucoma, diabetic retinopathy, and cataracts. About 900 adults at a Federally Qualified Health Center will be randomly assigned to one of the two exa…

This study is testing whether measuring blood flow in the retina can help detect early glaucoma. Researchers will use special dyes and imaging to see how blood vessels respond to oxygen. The goal is to find a reliable early warning sign for the disease. About 90 adults with early…

This trial tests whether a community-based screening program using advanced eye imaging (OCT, fundus photography, and pressure checks) can prevent vision loss from age-related macular degeneration, diabetic retinopathy, and glaucoma better than simple vision tests alone. About 60…

This study tests whether a personalized education and counseling program, called ComBaT Glaucoma, can encourage Black Americans at high risk for glaucoma to see an eye doctor regularly. The program is delivered through a community church setting. Researchers will track whether pa…

This pilot study tests whether a gentle, non-invasive electrical current applied to the brain can improve how people with tunnel vision (from retinitis pigmentosa, rod-cone dystrophy, or advanced glaucoma) navigate obstacles. Twenty adults will receive both real and sham stimulat…

This early-phase trial tests whether a one-hour occupational therapy session—teaching strategies like better lighting, contrast, and organizational tools—can help people with age-related macular degeneration, diabetic retinopathy, or glaucoma manage their medications. Fifty parti…

This study looks at whether a laser treatment called DSLT can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. Researchers will measure eye pressure at three times during one day before the laser and again six months after. The goal is …

This study looks at whether Xiidra, an FDA-approved eye drop for dry eye, can reduce eye discomfort and dryness in people with glaucoma who are already using multiple eye drops to control eye pressure. About 75 participants will receive Xiidra as part of their standard care and b…

This study tests whether a type of eye training called biofeedback can improve vision and quality of life in people with glaucoma. Glaucoma damages the optic nerve and can cause blind spots. The training teaches patients to move their eyes to use healthier parts of their retina. …

This early-stage trial tests whether insulin eye drops are safe for people with glaucoma and other optic nerve conditions. Researchers at Stanford will give different doses of insulin drops to 52 participants for 1-2 months. The main goal is to check for side effects, but they wi…

This study tests whether adding brimonidine eye drops can reduce eye redness in people with glaucoma who are already using netarsudil/latanoprost drops. About 35 adults aged 18-65 with open-angle glaucoma or high eye pressure will take part. The main goal is to see if the extra d…

This study is testing whether Baduanjin, a gentle form of exercise, can help older adults with glaucoma. Sixty participants will either do Baduanjin for 60 minutes daily (except Fridays) for eight weeks, or be placed on a waiting list. Researchers will measure changes in eye pres…

This study follows 50 people with advanced glaucoma for three years, using a special eye scan (OCT angiography) to measure blood flow around the optic nerve. Researchers want to see how these scans compare with standard vision tests in tracking the disease. The goal is to better …

This study uses special cameras to take detailed pictures of the eye's drainage system in people with glaucoma or high eye pressure. Half of the 50 participants will use Rhopressa eye drops daily for two weeks, while the other half will use artificial tears. The goal is to see if…

This study examines tear fluid for signs of inflammation in people with glaucoma who receive different treatments. Researchers will measure certain proteins in tears and eye pressure before and after treatment. The goal is to see if these tear markers can predict how well a treat…

This study looks at whether the thickness of a layer inside the eye (the choroid) can predict how well a gentle laser treatment works for glaucoma. Researchers will measure eye pressure and choroid thickness before and after the laser procedure in 20 adults with glaucoma. The goa…

This study will use advanced eye scans (OCT and OCTA) to compare the structure and blood flow of the choroid and retina in people with two main types of glaucoma: primary angle-closure disease and primary open-angle glaucoma. Researchers aim to better understand how these conditi…

This study is testing whether a simple vision screening program in general practice can help detect vision loss early in adults over 70 who have at least one chronic condition. Participants will have three vision tests done by their GP or nurse, then visit a collaborating opticia…

This study tests two simple ways to help people attend eye hospital appointments after being screened for age-related macular degeneration, diabetic retinopathy, or glaucoma. About 3,000 participants who need a follow-up visit will get either a text reminder, a home visit from a …

This study aims to understand how glaucoma impacts quality of life by asking 5000 adults with glaucoma to fill out questionnaires about their symptoms and daily activities. The questionnaires are given before treatment or surgery and again 3 to 6 months after. The goal is to lear…

This study looks at whether a slow-release injection (Durysta) can replace some daily eye drops for glaucoma, reducing eye surface inflammation. Researchers will measure a marker called caspase-1 in 20 adults with open-angle glaucoma. The goal is to see if fewer drops lead to a h…

This study is testing a new way to measure eye pressure during cataract and glaucoma surgery. Researchers will use a special sensor to track pressure changes and see if this helps predict and prevent problems after surgery. The study involves 150 adults having these surgeries at …

This study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …

This study looks at how glaucoma affects sleep, mood, alertness, and thinking by changing how the eye responds to light. Researchers will compare 120 adults with glaucoma to healthy volunteers aged 45-75. Participants will wear a sleep tracker and visit a lab to test their thinki…

This study follows 200 people with glaucoma for 3 years to see how their vision changes over time. Researchers will compare two different eye-testing machines to find which one spots vision loss earlier and more accurately. No new treatments are tested—the goal is to improve how …

This study uses special cameras to watch how eye tissues heal after minimally invasive glaucoma surgery. Researchers will follow 300 glaucoma patients to measure changes in the eye's drainage angle over time. The goal is to learn more about healing patterns and help improve futur…

This study looks at whether damage to the glycocalyx, a protective lining inside blood vessels, is linked to glaucoma. Researchers will compare 50 people with glaucoma to 50 without, using a non-invasive device to measure this lining under the tongue. The goal is to see if blood …

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study is testing a smart device called CONNECTDROP® that clips onto eye drop bottles to track how often glaucoma patients use their medication. About 200 adults with open-angle glaucoma will use the device and a smartphone app for one year. The goal is to see if the technolo…

This study tests a special microscope that takes live 3D images inside the eye during surgery. It aims to help surgeons see better when treating conditions like retinal detachment, macular holes, and cataracts. About 262 people will take part, including healthy volunteers and sur…

This study tests a new handheld eye scanner (Theia 1) against an existing one to see which takes better pictures of children's retinas. Researchers will scan 30 healthy adults and children to compare image quality and field of view. The goal is to improve diagnosis of eye disease…

This pilot study is testing whether a non-contact imaging technique called Brillouin microscopy can measure corneal stiffness in people with glaucoma. Researchers will compare these measurements between patients with high-tension glaucoma, normal-tension glaucoma, and healthy con…