GLAUCOMA

This study follows about 200 glaucoma patients who received the Hydrus implant (often with cataract surgery) to see if it safely lowers eye pressure for 8 to 14 years. Researchers will check pressure, medication use, and quality of life. The goal is to understand how well the imp…

This study tests whether a daily supplement called BrudyGlauco (containing DHA and citicoline) can help protect eyesight in people with glaucoma. Glaucoma damages the optic nerve and can lead to vision loss, and current treatments mainly focus on lowering eye pressure. The trial …

This study tests a device that sends a gentle electrical current through the eyes to see if it can improve vision in people with glaucoma. About 30 adults with open-angle glaucoma will receive either real or fake (sham) treatment. Researchers will measure changes in vision and ey…

This study tests a tiny implant placed inside the eye that slowly releases travoprost, a drug that lowers eye pressure. The goal is to see if it works better than daily eye drops for people with open-angle glaucoma or high eye pressure. About 610 adults will take part, and the im…

This study tests whether a laser treatment given before a Boston keratoprosthesis (a special plastic cornea implant) can help control eye pressure and prevent glaucoma damage. Twenty adults who need the cornea implant will receive one of two types of laser treatment 4 to 8 weeks …

This study tests the ELIOS laser, a new tool used during cataract surgery to treat glaucoma. The laser creates tiny channels in the eye's drainage system to lower pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal is to see if the laser…

This study tests a tiny implant that releases medication to lower eye pressure in people with glaucoma or high eye pressure who are also having cataract surgery. About 400 participants will receive either the implant during surgery or standard eye drops. The goal is to see if the…

This study tests a small implant placed inside the eye that slowly releases medication to lower eye pressure in people with glaucoma or high eye pressure. The goal is to see if it works as well as daily eye drops but with fewer doses. About 510 adults will take part, and the main…

This study looks at whether using pilocarpine eye drops after a combined cataract and glaucoma surgery (Kahook Dual Blade) helps lower eye pressure more than surgery alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients ach…

This study tests a small device called iStent to lower eye pressure in 60 adults with open-angle glaucoma and cataracts. Participants will receive the implant during cataract surgery. The goal is to see if it safely reduces pressure and helps control the disease.

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) all done at the same time as cataract surgery. The goal is to see which one lowers eye pressure best and has the fewest side effects. About 243 adults with mild…

This study tests a modified version of trabeculectomy, a surgery to lower eye pressure, in 20 people whose prior combined cataract and glaucoma surgery started to fail early. The goal is to see if this modified approach can better control intraocular pressure. Participants must h…

This study looks at whether a laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. About 40 adults who already take 1 to 3 eye pressure-lowering drops will receive the…

This study tests whether metformin, a widely used diabetes medication, can slow down vision loss in people with glaucoma. Researchers will give 125 adults with progressive glaucoma either metformin or a placebo for 24 months. The goal is to see if metformin can protect the optic …

This study tests a tiny implant that releases medication to lower eye pressure in people with glaucoma or high eye pressure who are also having cataract surgery. About 400 participants will receive either the implant during surgery or standard eye drops. The goal is to see if the…

This study tests a new, non-invasive eye imaging technique called hyperspectral imaging. It captures detailed images using many light wavelengths to find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in M…

This study tests whether using an AI tool to screen for glaucoma and other eye conditions at community health centers works better than usual care. About 1,800 adults at higher risk for eye disease will get a quick eye screening. If the AI finds a problem, patients are referred t…

This study is testing a new handheld device that automatically aligns to take detailed pictures of the back of the eye (retina) in adults and children. Researchers want to see if it can help detect eye diseases like glaucoma and retinal problems. About 50 volunteers and patients …

This study tests a vision screening program in Danish general practice for people over 70 with at least one chronic condition. The goal is to see if the screening can catch vision problems early and refer patients to eye specialists. About 460 participants will be recruited, and …

This study tests whether using telehealth tools like eye scans and pressure checks can find undiagnosed glaucoma earlier than just giving people information. Researchers will enroll 2,000 high-risk adults—including Black people 50+, Hispanic people 65+, and people with diabetes 5…

This study tests a special contact lens that measures eye pressure continuously over 24 hours in people with glaucoma or high eye pressure. The goal is to see if it works as well as the standard method (a quick office test). If successful, it could help doctors better manage glau…

This study aims to develop better ways to measure eye pressure, which is important for diagnosing and managing glaucoma. Researchers will compare two new, portable methods to the current standard tests in 200 adults getting routine eye exams. The goal is to find a method that is …

This study tests whether an artificial intelligence (AI) program can help detect glaucoma, a leading cause of blindness, in people with diabetes. About 1,040 adults with diabetes will have their eye photos checked either by the AI or by the usual method (a human grader). The goal…

This study compares a technology-enhanced eye exam done remotely (telemedicine) with a standard in-person eye exam to see which detects three leading causes of blindness—glaucoma, diabetic retinopathy, and cataracts—more effectively. About 900 adults who speak English, Spanish, A…

This study tests whether a community and faith-based program can encourage Black Americans at high risk for glaucoma to see an eye doctor. Researchers will provide education and extra resources to 60 participants and check if they get eye exams within 6 and 12 months. The goal is…

This study tests a special eye training technique called biofeedback for people with glaucoma, a disease that damages vision. The training helps patients use their remaining eyesight more effectively by teaching them to look with healthier parts of their retina. Researchers will …

This study tests whether a non-invasive brain stimulation technique called rtACS can help people with glaucoma. The treatment aims to activate damaged cells in the eye and improve vision. Researchers will measure changes in visual field tests before and after treatment. The study…

This study tests a device that delivers mild electrical pulses to the eye to see if it can improve vision loss caused by glaucoma. About 50 adults with open-angle glaucoma will receive either the real treatment or a sham (fake) treatment. The goal is to check if this approach is …

This study tests whether adding brimonidine eye drops can reduce eye redness in adults with glaucoma who are already using netarsudil/latanoprost drops. About 35 people aged 18-65 with open-angle glaucoma or high eye pressure will take part. The main goal is to see if the extra d…

This study looks at whether Baduanjin, a gentle exercise routine, can help older adults with glaucoma. 60 people with high eye pressure will either do Baduanjin for 8 weeks or be placed on a waitlist. Researchers will measure changes in eye pressure, mood, and quality of life.

This study compares four new tonometer tips that don't require numbing eye drops to the standard tip used with anesthesia. Researchers want to see which tip is most comfortable and tolerable for patients. The goal is to develop a better tip for home use, making it easier for peop…

This study looks at whether Xiidra, a drug already approved for dry eye, can reduce eye discomfort in people with glaucoma who use multiple eye drops. About 75 participants will receive Xiidra as part of their normal care, and researchers will track changes in eye staining, dryne…

This early-stage trial tests whether insulin eye drops are safe for people with glaucoma and other optic nerve diseases. About 52 participants will use the drops for 1-2 months while researchers monitor side effects and check for any changes in eye structure or vision. The goal i…

This study looks at whether measuring blood flow in the eye's retina can help find early signs of glaucoma, a leading cause of blindness. Researchers will test 90 adults with early glaucoma or healthy eyes by comparing blood flow while breathing air versus pure oxygen. The goal i…

This study tests two different eye imaging machines (OCT) to see which one takes better pictures of the back of the eye in children. Researchers will compare a new contact device with a noncontact device in 30 participants, including healthy adults and children. The goal is to fi…

This study uses a special camera (Brillouin microscopy) to measure how stiff the cornea is in people with glaucoma and healthy volunteers. The goal is to see if corneal stiffness can help doctors better understand glaucoma risk and how well treatment works. About 60 adults will t…

This study checks how well a new device called TonoVera measures eye pressure in people with glaucoma. Researchers will compare it to two other common devices. About 300 adults aged 18 to 99 who can attend one appointment are needed. The goal is to see if the new tool is as accur…

This study follows 200 people with glaucoma for 3 years to see how well two different vision test devices measure changes in their eyesight. Participants will have regular eye exams using both devices and an imaging scan. The goal is to find the best way to detect when the diseas…

This study looks at whether a slow-release eye injection (Durysta) can reduce eye surface inflammation caused by daily glaucoma eye drops. Researchers will measure a marker of inflammation (caspase-1) in 20 adults with open-angle glaucoma or high eye pressure. The goal is to see …

This study uses advanced eye imaging to see how the eye's drainage system heals after minimally invasive glaucoma surgery. Researchers will track changes in eye tissues over time in 300 glaucoma patients. The goal is to learn more about healing patterns to help improve and standa…

This study looks at how fluid drains from the eye during cataract or glaucoma surgery. By measuring eye pressure during the operation, doctors hope to better predict and improve recovery. About 150 adults having surgery at Mount Sinai will take part.

This study gathers detailed eye scans from 180 adults with healthy eyes or conditions like retinal disease, glaucoma, or corneal disease. The goal is to collect data that may help doctors better understand and diagnose these conditions in the future. Participants will have their …

This study examines whether damage to the glycocalyx, a protective lining inside blood vessels, is linked to glaucoma. Researchers will compare 100 adults with and without glaucoma using a non-invasive test. The goal is to find new ways to detect or understand the disease, not to…

This study looks at how glaucoma changes the way the eye responds to light, and whether that affects sleep, mood, alertness, and thinking. Researchers will compare 120 adults with glaucoma to healthy adults aged 45-75. Participants will wear a sleep tracker, answer questionnaires…

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…

This study aims to understand how glaucoma impacts quality of life by asking 5,000 adults with glaucoma to fill out questionnaires about their symptoms and daily functioning. Participants will complete surveys before starting or changing treatment, and again 3 to 6 months later. …

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…