GLAUCOMA

This study looks at whether using pilocarpine eye drops after a combined cataract and glaucoma surgery (Kahook Dual Blade) helps lower eye pressure more than surgery alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients ach…

This study tests a tiny implant that releases medication to lower eye pressure in people with glaucoma or high eye pressure who are also having cataract surgery. About 400 participants will receive either the implant plus a special lens or standard eye drops. The goal is to see i…

This study tests whether metformin, a widely used diabetes medicine, can slow down vision loss in people with glaucoma. Researchers will give 125 adults with worsening glaucoma either metformin or a placebo for 24 months and measure changes in the optic nerve and visual field. Th…

This study tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with mild-to-moderate glaucoma or high eye pressure. About 400 participants will receive either the implant with a special lens or standard eye drops. The goal is …

This study tests a tiny implant placed inside the eye that slowly releases medication to lower eye pressure. It is for adults with open-angle glaucoma or high eye pressure. The goal is to see if the implant is safe and works better than standard eye drops.

This study tests a modified surgery to lower eye pressure in people with glaucoma whose previous combined cataract and glaucoma surgeries have not worked well. The new approach avoids certain eye tissues to improve results. Researchers will measure eye pressure in 20 participants…

This study tests a small device called iStent to lower eye pressure in adults with both open-angle glaucoma and cataracts. About 60 people will receive the iStent during cataract surgery. The goal is to see if it safely helps control eye pressure, a key factor in managing glaucom…

This study tests a device called Eyetronic that sends a mild electrical current through the head to the eyes. The goal is to see if it can improve vision in people with open-angle glaucoma. About 30 adults with moderate vision loss will receive either real or fake (sham) treatmen…

This study tests a device that sends mild electrical pulses through the eye to treat vision loss in people with open-angle glaucoma. About 50 adults with worsening vision will receive either real or sham (fake) stimulation to see if it safely improves their visual field. The goal…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study tests the ELIOS laser, a new tool used during cataract surgery to treat glaucoma. The laser creates tiny channels in the eye's drainage system to lower pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal is to see if the laser…

This study follows about 200 glaucoma patients who received the Hydrus implant (often with cataract surgery) to see if it safely lowers eye pressure for 8 to 14 years. Researchers will check pressure, medication use, and quality of life. The goal is to understand how well the imp…

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) done at the same time as cataract surgery. About 243 adults with mild to moderate open-angle glaucoma will take part. The goal is to see which surgery lowers ey…

This Phase 3 trial tests a tiny implant placed inside the eye that slowly releases travoprost, a drug to lower eye pressure. The goal is to see if it works as well as daily eye drops for people with open-angle glaucoma or high eye pressure. About 510 adults will take part, and th…

This study tests whether a daily supplement called BrudyGlauco (containing DHA and citicoline) can help protect eyesight in people with glaucoma. Glaucoma damages the optic nerve and can lead to vision loss, and current treatments mainly focus on lowering eye pressure. The trial …

This study looks at whether a laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. About 40 adults who already take 1 to 3 eye pressure-lowering drops will receive the…

This study is testing a new handheld device that automatically aligns to take detailed pictures of the back of the eye (retina) in adults and children. Researchers want to see if it works well in a clinic setting. About 50 healthy volunteers and eye clinic patients will participa…

This study tests whether an artificial intelligence (AI) program can accurately detect glaucoma, a leading cause of blindness, in people with diabetes. About 1,040 adults with diabetes will have their eye photos checked by either the AI or a human grader. The goal is to see if th…

This study aims to develop better ways to measure eye pressure, which is important for diagnosing and managing glaucoma. Researchers will compare two new, more objective and portable methods to the current standard tests. About 200 adults getting routine eye exams will participat…

This study tests whether using an AI tool to screen for glaucoma and other eye conditions at community health centers works better than usual care. About 1,800 adults at higher risk for eye disease will get a quick eye screening. If the AI finds a problem, patients are referred t…

This study tests a new, non-invasive eye imaging technique called hyperspectral imaging. It captures detailed images using many light wavelengths to find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in M…

This study tests a vision screening program in Danish general practice for people over 70 with at least one chronic condition. The goal is to see if the screening can catch vision problems early and refer patients to eye specialists. About 460 participants will be recruited, and …

This study tests whether using telehealth tools like eye scans and pressure checks can find undiagnosed glaucoma earlier than just giving people information. Researchers will enroll 2,000 high-risk adults—including Black people 50+, Hispanic people 65+, and people with diabetes 5…

This study compares a technology-enhanced eye exam done remotely (telemedicine) with a standard in-person eye exam to see which detects three leading causes of blindness—glaucoma, diabetic retinopathy, and cataracts—more effectively. About 900 adults who speak English, Spanish, A…

This study tests whether a community and faith-based program can encourage Black Americans at high risk for glaucoma to see an eye doctor. About 60 participants will receive education and extra resources to help them get eye exams. The goal is to prevent blindness by making eye c…

This study tests whether adding brimonidine eye drops can reduce eye redness in adults with glaucoma who are already using netarsudil/latanoprost drops. About 35 people aged 18-65 with open-angle glaucoma or high eye pressure will take part. The main goal is to see if the extra d…

This study looks at whether Baduanjin, a gentle exercise routine, can help older adults with glaucoma. Sixty people with high eye pressure will be split into two groups: one does Baduanjin for 60 minutes daily (except Fridays) for eight weeks, the other waits. Researchers will me…

This study tests a special eye exercise program called biofeedback training for people with glaucoma, a disease that can damage eyesight. The training helps patients learn to use the healthy parts of their vision more effectively. Researchers will compare 70 participants who rece…

This study tests whether a non-invasive brain stimulation technique called rtACS can help people with glaucoma. The treatment aims to activate damaged cells in the eye and improve vision. Researchers will measure changes in visual field tests before and after treatment. The study…

This study compares four new tonometer tips that don't require numbing eye drops to the standard tip used with anesthesia. Researchers want to see which tip is most comfortable and tolerable for patients. The goal is to develop a better tip for home use, making it easier for peop…

This study looks at whether Xiidra, a drug already approved for dry eye, can reduce eye discomfort in people with glaucoma who use multiple eye drops. About 75 participants will receive Xiidra as part of their normal care, and researchers will track changes in eye staining, dryne…

This early-stage trial tests whether insulin eye drops are safe for people with glaucoma and other optic nerve diseases. About 52 participants will use the drops for 1-2 months while researchers monitor side effects and check for any changes in eye structure or vision. The goal i…

This study is gathering detailed eye scans from 180 people, including those with healthy eyes and those with retinal disease, glaucoma, or corneal conditions. The goal is to collect data that may help researchers better understand these eye diseases. Participants will have their …

This study looks at whether certain proteins in tears can predict how well glaucoma treatments lower eye pressure. Researchers will collect tear samples and measure eye pressure before and after three different procedures in 24 adults with glaucoma. The goal is to understand infl…

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand eye diseases. About 1,200 people with various eye conditions or healthy …

This study follows 200 adults with glaucoma for 3 years to see how their vision changes over time. Researchers will compare two different vision test machines (Compass and Humphrey) and also look at eye scans to find the best way to detect worsening of the disease. The goal is to…

This study looks at whether switching from daily glaucoma eye drops to a long-lasting injectable implant (Durysta) can reduce inflammation on the eye's surface. Researchers will measure a marker of inflammation called caspase-1 in 20 adults with open-angle glaucoma or ocular hype…

This study looks at whether the thickness of a layer in the eye (the choroid) can predict how well a special laser treatment lowers eye pressure in people with glaucoma. Researchers will measure eye pressure and choroid thickness before, days after, and one month after the laser …

This study uses advanced, non-invasive eye scans (OCT and OCTA) to look at the structure and blood flow in the back of the eye in people with different types of glaucoma. Researchers will compare these images to those from healthy volunteers to find new details about how the dise…

This study tests a special contact lens that measures eye pressure continuously over 24 hours in people with glaucoma or high eye pressure. The goal is to see if it works as well as the standard method, which only takes snapshots. If successful, it could help doctors better manag…

This study looks at whether measuring blood flow in the eye's retina can help find early signs of glaucoma, a leading cause of blindness. Researchers will test 90 adults with early glaucoma or healthy eyes by comparing blood flow while breathing air versus pure oxygen. The goal i…

This study tests two different eye imaging machines (OCT) to see which one takes better pictures of the back of the eye in children. Researchers will compare a new contact device with a noncontact device in 30 participants, including healthy adults and children. The goal is to fi…

This study uses a special camera (Brillouin microscopy) to measure how stiff the cornea is in people with glaucoma and healthy volunteers. The goal is to see if corneal stiffness can help doctors better understand glaucoma risk and how well treatment works. About 60 adults will t…

This study checks how well a new device called TonoVera measures eye pressure in people with glaucoma. Researchers will compare it to two other common devices. About 300 adults aged 18 to 99 who can attend one appointment are needed. The goal is to see if the new tool is as accur…

This study looks at how fluid moves in the eye during cataract and glaucoma surgery. Researchers will measure eye pressure and fluid drainage during the operation to help surgeons make better decisions afterward. About 150 adults having these surgeries will take part.

This study looks at a thin coating inside blood vessels, called glycocalyx, in people with primary open-angle glaucoma. Researchers want to see if damage to this coating is linked to the eye disease. About 100 adults will join, half with glaucoma and half without. The goal is to …

This study uses advanced eye imaging to see how the eye's drainage system heals after minimally invasive glaucoma surgery. Researchers will track changes in eye tissues over time in 300 glaucoma patients. The goal is to learn more about healing patterns to help improve and standa…

This study looks at how glaucoma changes the way the eye responds to light, and whether that affects sleep, mood, alertness, and thinking. Researchers will compare 120 adults with glaucoma to healthy adults aged 45-75. Participants will wear a sleep tracker, answer questionnaires…

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…

This study aims to understand how glaucoma impacts quality of life by asking 5,000 adults with glaucoma to fill out questionnaires about their symptoms and daily functioning. Participants will complete surveys before starting or changing treatment, and again 3 to 6 months later. …