Open-angle glaucoma

This study tests a gel stent implant designed to lower eye pressure in people with glaucoma. About 130 adults aged 45 and older will receive the stent through one of two surgical methods. Researchers will check safety and how well the stent reduces eye pressure over 12 months.

This phase 3 trial tests TFC-003, a new eye drop, in 188 adults with primary open-angle glaucoma or ocular hypertension. Participants use the drops twice daily for up to 24 weeks. The main goal is to see if TFC-003 lowers eye pressure better than an active control. The study is c…

This phase 3 trial tests whether a preservative-free version of bimatoprost eye drops works as well as the standard Lumigan drops for lowering eye pressure. About 600 adults with primary open-angle glaucoma or ocular hypertension in both eyes will receive either the new formulati…

This study compares two devices used during cataract surgery to treat open-angle glaucoma. About 194 adults with mild to moderate glaucoma and cataracts will receive either the ELIOS device or a competitor device. The main goal is to see which one lowers eye pressure more effecti…

This study is checking whether a small metal implant called the Hydrus Microstent stays in the right place after being placed during cataract surgery. The implant is designed to help drain fluid from the eye and lower pressure in people with open-angle glaucoma. Researchers will …

This study tests a tiny implant called MINIject s+ to help drain fluid and lower eye pressure in people with open-angle glaucoma. About 60 adults will receive the implant during surgery, and researchers will check if it is placed correctly and is easy for surgeons to use. The goa…

This study tests whether a travoprost drug implant (iDose TR) plus a tiny stent (iStent infinite) can lower eye pressure better than the implant alone in people with open-angle glaucoma or high eye pressure. About 150 adults will receive either the combo or a sham procedure and b…

This study tests a small implant called the PRESERFLO™ MicroShunt XI in people with primary open-angle glaucoma whose eye pressure remains high despite maximum medication. The implant is placed under the eye's surface to drain fluid and lower pressure. Researchers will check if i…

This study looks at whether adding a combination of two eye drops (netarsudil and latanoprost) after laser treatment works better than adding just one drop (latanoprost) for lowering eye pressure in people with glaucoma. About 36 adults with mild to moderate glaucoma will take pa…

This early-stage trial is testing a single dose of ER-100, a gene therapy designed to reverse age-related changes in retinal cells, in 18 adults with open-angle glaucoma or NAION. Participants receive the therapy via an eye injection and take doxycycline for 8 weeks to activate i…

This study tests whether adding a physical activity program to standard care can improve health in older women who have three conditions: underactive thyroid (hypothyroidism), glaucoma (high pressure in the eyes), and fatty liver. Researchers will measure changes in eye pressure,…

This study compares two FDA-approved laser treatments for open-angle glaucoma: the standard SLT and a newer, non-contact version called DSLT. Both aim to lower eye pressure and prevent vision loss. About 172 adults with glaucoma or high eye pressure will be randomly assigned to o…

This early study tests a new gene therapy called GVB-2001 for people with primary open-angle glaucoma. The treatment is given as an injection into the eye to help lower high pressure inside the eye. About 6 adults aged 18 to 75 with glaucoma for at least a year will take part. Th…

This study tests whether a combination eye drop (Rocklatan) works better than a standard drop (Latanoprost) at lowering eye pressure over a full 24-hour period in adults with open-angle glaucoma or ocular hypertension. About 30 participants will use one drop in each eye nightly. …

This study compares two small implants (XEN-63 and PRESERFLO) placed during a quick surgery to lower eye pressure in adults with open-angle glaucoma. About 166 participants will be randomly assigned to one implant and followed for 2 years. The goal is to see if PRESERFLO works as…

This study tests whether a quick laser treatment called DSLT can help people with glaucoma or high eye pressure use fewer daily eye drops. Sixty adults whose eye pressure is already controlled with 1-3 types of drops will receive the laser in one or both eyes. Researchers will ch…

This study tests a new laser treatment called Direct Selective Laser Trabeculoplasty (DSLT) for people with pigmentary glaucoma, a type of glaucoma that can lead to vision loss. The laser is applied directly through the eye's surface in just a few seconds, aiming to lower high ey…

This study tests a new preservative-free eye drop combination (QLS-111-FDC) to lower eye pressure in people with open-angle glaucoma or ocular hypertension. About 60 adults with mild to moderate disease will receive the treatment. The goal is to see if it safely reduces eye press…

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) done at the same time as cataract surgery. About 243 adults with mild to moderate open-angle glaucoma will take part. The goal is to see which surgery lowers ey…

This Phase 3 trial tests a second-generation implant placed inside the eye that slowly releases travoprost, a drug that lowers eye pressure. The study will enroll 510 adults with open-angle glaucoma or high eye pressure. The goal is to see if the implant is safe and effective at …

This study is testing a special laser called ELIOS to treat glaucoma at the same time as cataract surgery. The laser creates tiny channels in the eye to help fluid drain and lower eye pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal i…

This study tests whether a tiny drainage device called the Preserflo MicroShunt can lower eye pressure as well as the standard trabeculectomy surgery in adults with open-angle glaucoma. One hundred participants will be randomly assigned to receive one of the two procedures and wi…

This study tests whether a weak electrical current applied to the eye's surface can improve vision in people with open-angle glaucoma. Fifty adults with worsening vision loss will receive either real or sham stimulation over several sessions. The goal is to see if this safe, non-…

This study looks at whether lifestyle changes (diet and exercise) plus CPAP therapy can reduce eye pressure in people with glaucoma, sleep apnea, and obesity. Forty participants will be split into two groups: one gets CPAP alone, the other gets CPAP plus lifestyle changes. The ma…

This study tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 610 participants will receive either the implant, timolol eye drops, a sham procedure, or placebo drops. The main goal …

This early study tests a new surgical tool that opens up the eye's natural drainage channels to lower pressure in people with open-angle glaucoma who are also having cataract surgery. About 70 participants will receive the device during their cataract procedure. The main goal is …

This study tests a redesigned inserter for the travoprost implant, a tiny device placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 30 adults will receive the implant using the updated inserter. The main goal is to see if doct…

This early study tests whether QLS-111 eye drops can improve blood flow to the back of the eye in people with non-proliferative diabetic retinopathy or certain types of glaucoma. Fourteen participants will use the drops twice daily for two weeks. The main goal is to measure chang…

This study tests whether stingless bee honey (Kelulut honey) can help young people with juvenile open-angle glaucoma. Sixty participants will either take 30 grams of honey daily for three months or receive no honey. Researchers will measure changes in inflammation, eye nerve thic…

This study tests a new tool called the MIST device to lower eye pressure in people with primary open-angle glaucoma. About 25 adults aged 40 and older whose eye pressure is not well controlled with eye drops will receive the procedure. Researchers will check how safe the device i…

This study tests a small device called iStent that is placed in the eye during cataract surgery to help lower pressure in people with open-angle glaucoma. Sixty adults with both glaucoma and cataracts will be enrolled. The goal is to see if the iStent is safe and effective at red…

This study tests a tiny implant placed inside the eye during cataract surgery that slowly releases travoprost, a drug that lowers eye pressure. About 132 adults with glaucoma or high eye pressure will receive either the implant plus surgery or surgery alone. The goal is to see if…

This study tests whether a daily supplement called BrudyGlauco (containing DHA and citicoline) can help protect eyesight in people with glaucoma. About 108 participants will take either the supplement or a placebo for 12 months. The goal is to see if it slows vision loss and impr…

This study tests a device called the OMNI 3.1 Surgical System to see if it safely lowers eye pressure in people with primary open-angle glaucoma. About 25 adults aged 45 and older will take part. The main goal is to check if eye pressure drops by at least 20% three months after s…

This Phase 3 trial tests a new eye drop called HUC3-637 in 206 adults with primary open-angle glaucoma or ocular hypertension. The goal is to see if it safely lowers eye pressure better than an existing active control. Participants will use the drops daily and have their eye pres…

This study compares two surgical options—iStent inject and goniotomy with Kahook Dual Blade—performed during cataract surgery in 100 people with open-angle glaucoma. The goal is to see which method better lowers eye pressure and reduces the number of daily eye drops needed. Both …

This study compares two first-line treatments for primary open-angle glaucoma or high eye pressure: a one-time laser procedure (selective laser trabeculoplasty) versus daily latanoprost eye drops. Researchers will track how well each lowers eye pressure and note any side effects …

This trial tests a tiny device called the VisiPlate shunt to help drain fluid and lower eye pressure in people with open-angle glaucoma that hasn't responded to other treatments. About 165 adults will receive the implant and be followed to see if their eye pressure drops by at le…

This study tests a device called the Calibreye System, a small implant placed in the eye to help drain fluid and lower pressure in people with open-angle glaucoma. Researchers will check if it is safe and works well over 12 months in 60 adults. The goal is to see if the device ca…

This study tests whether metformin, a drug used for diabetes, can protect the optic nerve and slow vision loss in people with glaucoma. 125 participants with worsening glaucoma will take either metformin or a placebo for 24 months. The goal is to see if metformin can slow the thi…

This study tests if two devices placed in the eye can safely lower eye pressure in people with moderate to severe open-angle glaucoma. Participants have not responded well to drops or laser and are considering surgery. The goal is to see if these implants can be a less invasive a…

This study tests whether adding pilocarpine eye drops after combined cataract and Kahook Dual Blade surgery helps lower eye pressure more than standard drops alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients achieve a 2…

This study tests whether a device called Eyetronic, which delivers mild electrical pulses through the eyes, can help people with glaucoma. Glaucoma damages the optic nerve and can lead to vision loss. The trial will compare the active device to a sham (fake) version in 30 adults …

This phase 3 trial tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant with a special lens or standard eye drops. The goal is to see if…

This study tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant plus a special lens or standard eye drops. The goal is to see if the imp…

This study looks at whether a gentle laser treatment (SLT) works as well as the standard version for people with glaucoma or high eye pressure. It also tests if getting the gentle laser once a year can delay or prevent the need for daily eye drops. About 790 adults will take part…

This study compares two surgical procedures—trabeculectomy with mitomycin C and slow coagulation trans-scleral cyclophotocoagulation—for lowering eye pressure in patients with open-angle glaucoma that is not controlled by medication. All participants are over 40 and have had cata…

This study tests a new smart contact lens that measures eye pressure continuously for 24 hours, compared to standard spot checks. It involves 12 adults with glaucoma or high eye pressure. The goal is to see if the lens provides accurate readings day and night, which could lead to…

This study is testing whether measuring blood flow in the retina can help detect early glaucoma. Researchers will use special dyes and imaging to see how blood vessels respond to oxygen. The goal is to find a reliable early warning sign for the disease. About 90 adults with early…

This long-term study is looking for the best methods to detect glaucoma and track its worsening over time, especially in people with nearsightedness (myopia) and those of African or European descent. Researchers will use advanced eye imaging to monitor changes in the back of the …

This study looks at whether a laser treatment called DSLT can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. Researchers will measure eye pressure at three times during one day before the laser and again six months after. The goal is …

This study tests whether adding brimonidine eye drops can reduce eye redness in people with glaucoma who are already using netarsudil/latanoprost drops. About 35 adults aged 18-65 with open-angle glaucoma or high eye pressure will take part. The main goal is to see if the extra d…

This study is testing whether Baduanjin, a gentle form of exercise, can help older adults with glaucoma. Sixty participants will either do Baduanjin for 60 minutes daily (except Fridays) for eight weeks, or be placed on a waiting list. Researchers will measure changes in eye pres…

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study uses special cameras to take detailed pictures of the eye's drainage system in people with glaucoma or high eye pressure. Half of the 50 participants will use Rhopressa eye drops daily for two weeks, while the other half will use artificial tears. The goal is to see if…

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study will use advanced eye scans (OCT and OCTA) to compare the structure and blood flow of the choroid and retina in people with two main types of glaucoma: primary angle-closure disease and primary open-angle glaucoma. Researchers aim to better understand how these conditi…

This study uses special cameras to take detailed pictures of the back of the eye in healthy people and those with glaucoma. Researchers want to see how blood flow and nerve cells change in glaucoma. The goal is to better understand the disease, not to test a new treatment.

This study follows 132 adults having glaucoma surgery to see how their quality of life changes over six months. Patients fill out a questionnaire about vision-related daily activities before and after surgery. The goal is to compare different surgical techniques from the patient'…

This study looks at fluid and tissue samples from the eyes of people with glaucoma and cataracts, and compares them to samples from people with cataracts only. The goal is to find chemical and protein patterns that could help doctors diagnose or track glaucoma better in the futur…

This study looks at whether a slow-release injection (Durysta) can replace some daily eye drops for glaucoma, reducing eye surface inflammation. Researchers will measure a marker called caspase-1 in 20 adults with open-angle glaucoma. The goal is to see if fewer drops lead to a h…

This study uses a special ultrasound to take detailed pictures inside the eye after a type of glaucoma surgery. Researchers want to see how the eye heals and whether those images can predict how well the surgery controls eye pressure. Thirty adults with open-angle glaucoma who ha…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study looks at how glaucoma affects sleep, mood, alertness, and thinking by changing how the eye responds to light. Researchers will compare 120 adults with glaucoma to healthy volunteers aged 45-75. Participants will wear a sleep tracker and visit a lab to test their thinki…

This study aims to understand the natural bacteria living on the surface of the eye in both healthy people and those with certain eye conditions. Researchers will collect eye swabs from 500 adults in middle Tennessee to build a database of what a normal eye microbiome looks like.…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study looks at whether damage to the glycocalyx, a protective lining inside blood vessels, is linked to glaucoma. Researchers will compare 50 people with glaucoma to 50 without, using a non-invasive device to measure this lining under the tongue. The goal is to see if blood …

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study is testing a smart device called CONNECTDROP® that clips onto eye drop bottles to track how often glaucoma patients use their medication. About 200 adults with open-angle glaucoma will use the device and a smartphone app for one year. The goal is to see if the technolo…

This study looks at how caffeine changes blood flow in the back of the eye in people with glaucoma and in healthy volunteers. Researchers will use a special camera to measure blood flow before and after drinking caffeine. The goal is to understand if caffeine affects eye health d…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study looks at how vision loss from glaucoma affects how often and how far older adults get out and about, known as 'life space.' Researchers will use questionnaires and vision tests to compare people with glaucoma to those without. The goal is to understand the real-world i…

This pilot study is testing whether a non-contact imaging technique called Brillouin microscopy can measure corneal stiffness in people with glaucoma. Researchers will compare these measurements between patients with high-tension glaucoma, normal-tension glaucoma, and healthy con…