Tiny tube could tame glaucoma without daily drops

NCT ID NCT07235592

Recruiting now Disease control Sponsor: Santen SAS Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study tests a small implant called the PRESERFLO™ MicroShunt XI in people with primary open-angle glaucoma whose eye pressure remains high despite maximum medication. The implant is placed under the eye's surface to drain fluid and lower pressure. Researchers will check if it safely reduces pressure by at least 20% and keeps it in a healthy range for 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PRESERFLO™ MicroShunt XI implant (a tiny tube placed in the eye to drain fluid and lower pressure)
What this could lead to: If it works, this could offer a safe, long-term way to control eye pressure in glaucoma patients, possibly reducing the need for daily eye drops.
What could go wrong: This is a mid-stage study with only 112 participants, so results may not apply to everyone. The implant is a surgical device, so risks include infection, scarring, or the device not working as expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

open-angle glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY OPEN ANGLE GLAUCOMA

Contacts and locations

Locations

AKH Wien
RECRUITING

Vienna, Austria
Glaucoma Clinic, UZ Leuven
RECRUITING

Leuven, Belgium
Guy's and St. Thomas' NHS Foundation Trust
RECRUITING

London, United Kingdom
Hospital Clinico San Carlos
NOT_YET_RECRUITING

San Carlos, Spain
Internationale Innovative Opthalmochirurgie GbR
RECRUITING

Düsseldorf, Germany
Irccs Fondazione G. B. Bietti
RECRUITING

Rome, Italy
Moorfields Eye Hospital NHS Foundation Trust
NOT_YET_RECRUITING

London, United Kingdom
Policlinico Universitario Molinette
NOT_YET_RECRUITING

Turin, Italy
ULS Santa Maria, Lisboa
NOT_YET_RECRUITING

Lisbon, Portugal
Universiteitskliniek voor Oogheelkunde Maastricht
NOT_YET_RECRUITING

Maastricht, Netherlands
Universitätsklinikum Tübingen, Department für Augenheilkunde
NOT_YET_RECRUITING

Tübingen, Germany

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