New hope for down syndrome vision loss: light therapy trial launches
NCT ID NCT07135167
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests a treatment called corneal crosslinking (CXL) for people with Down syndrome who have keratoconus, a condition where the cornea thins and bulges, blurring vision. The procedure uses vitamin B2 eye drops and ultraviolet light to strengthen the cornea. Researchers want to see if it can slow or stop vision loss. The study will enroll 225 people aged 8 and older and follow them for 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- riboflavin (vitamin B2) eye drops and ultraviolet (UVA) light
- What this could lead to
- If it works, this could offer a way to slow or stop vision loss from keratoconus in people with Down syndrome, helping them keep their sight longer.
- What could go wrong
- This is still experimental and not FDA-approved. The study is relatively small (225 people) and only follows participants for 6 months, so long-term benefits or risks are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Woolfson Eye Institute
RECRUITINGAtlanta, Georgia, 30328, United States
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Woolfson Eye Institute
RECRUITINGAtlanta, Georgia, 30349, United States
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Woolfson Eye Institute
RECRUITINGCanton, Georgia, 30114, United States
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Woolfson Eye Institute
RECRUITINGCumming, Georgia, 30041, United States
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Woolfson Eye Institute
RECRUITINGDouglasville, Georgia, 30134, United States
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Woolfson Eye Institute
RECRUITINGLawrenceville, Georgia, 30043, United States
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Woolfson Eye Institute
RECRUITINGMarietta, Georgia, 30066, United States
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Woolfson Eye Institute
RECRUITINGSnellville, Georgia, 30078, United States
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Woolfson Eye Institute
RECRUITINGAsheville, North Carolina, 28803, United States
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Woolfson Eye Institute
RECRUITINGChattanooga, Tennessee, 37421, United States
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Woolfson Eye Institute
RECRUITINGJohnson City, Tennessee, 37615, United States
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Woolfson Eye Institute
RECRUITINGKnoxville, Tennessee, 37922, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a simple eyeglass test sharpen vision in keratoconus?
- Can a donor corneal lenticule patch up a thinning cornea?
- A piece of your own cornea might patch a thinning one — a trial puts it to the test
- Can a simple eye treatment stop the need for a corneal transplant?
- Eye insert could ease allergy symptoms for contact lens wearers
- Promising new eye treatment could halt vision loss from keratoconus