Eye insert could ease allergy symptoms for contact lens wearers

NCT ID NCT04418999

Completed Symptom relief Sponsor: Illinois College of Optometry Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps and eye dryness better than the gel. Results may point to a simpler treatment option that doesn't require daily drops.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexamethasone ophthalmic insert
What this could lead to: If it works, this could offer a more convenient, doctor-administered treatment for allergy and dry eye symptoms in keratoconus patients who wear contact lenses.
What could go wrong: This is a very early, small trial with only 36 participants, so results may not be conclusive. The insert may not work better than the standard gel, and there are risks like increased eye pressure.

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Conditions

The condition(s) this trial relates to.

allergic disease atopic conjunctivitis dry eye syndrome keratoconus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALLERGY DRY EYE KERATOCONUS

Contacts and locations

Locations

Illinois Eye Institute

Chicago, Illinois, 60616, United States

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