Can a new eye drop soothe severe dry eye?

NCT ID NCT07740564

Not yet recruiting Disease control Sponsor: Ocumension Therapeutics (Suzhou) Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This clinical trial is testing whether an experimental eye drop called OT202 can improve symptoms and repair the eye surface in people with moderate to severe dry eye. About 842 adults aged 30 to 75 with a history of dry eye will receive either OT202 or a placebo drop three times a day for 8 weeks. The study will measure changes in eye dryness and corneal damage, and will also track long-term safety over up to 54 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: OT202 ophthalmic solution (1%)
What this could lead to: If successful, OT202 eye drops could offer a new treatment option to relieve dryness and repair the eye surface in people with moderate to severe dry eye.
What could go wrong: This is a Phase 3 trial, but results are not guaranteed. The treatment may not prove more effective than placebo, and long-term safety is still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dry eye syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRY EYE

Contacts and locations

Locations

Affiliated Hospital of Yunnan University (The Second People's Hospital of Yunnan Province / Yunnan Eye Hospital)

Kunming, Yunnan, 650021, China
Changsha Aier Eye Hospital

Changsha, Hunan, 410015, China
Changzhou Third People's Hospital

Changzhou, Jiangsu, 213001, China
Chongqing Aier Eye Hospital

Chongqing, Chongqing Municipality, 400020, China
Eye Hospital, WMU

Wenzhou, Zhejiang, 325027, China
Hainan Eye Hospital of Zhongshan Ophthalmic Center, Sun Yat-sen University

Haikou, Hainan, 570102, China
Harbin No.242 Hospital

Harbin, Heilongjiang, 150066, China
Nanjing Medical University Eye Hospital

Nanjing, Jiangsu, 210029, China
Ningbo Eye Hospital

Ningbo, Zhejiang, 315040, China
Northern Jiangsu People's Hospital

Yangzhou, Jiangsu, 225001, China
Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China
Peking University People's Hospital

Beijing, Beijing Municipality, 100044, China
People's Hospital of Ningxia Hui Autonomous Region

Yinchuan, Ningxia, 750002, China
Qilu Hospital of Shandong University

Jinan, Shandong, 250012, China
Qingdao Eye Hospital of Shandong First Medical University

Qingdao, Shandong, 266011, China
Renmin Hospital of Wuhan University

Wuhan, Hubei, 430060, China
Shanghai Eye Disease Prevention and Treatment Center

Shanghai, Shanghai Municipality, 200040, China
Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong

Shantou, Guangdong, 515041, China
Shanxi Eye Hospital

Taiyuan, Shanxi, 30002, China
Shenzhen Eye Hospital

Shenzhen, Guangdong, 518040, China
The 2nd Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150086, China
The First Affiliated Hospital of Bengbu Medical University

Bengbu, Anhui, 233004, China
The First Affiliated Hospital of China Medical University

Shenyang, Liaoning, 110001, China
The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, 116011, China
The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine

Guiyang, Guizhou, 550001, China
The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First People's Hospital of Xuzhou

Xuzhou, Jiangsu, 221000, China
The Fourth People's Hospital of Shenyang

Shenyang, Liaoning, 110031, China
The People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi, 530021, China
The Second Affiliated Hospital of Anhui Medical University

Hefei, Anhui, 230601, China
The Second Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310009, China
The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, 50000, China
The Third Xiangya Hospital of Central South University

Changsha, Hunan, 410013, China
Tianjin Eye Hospital

Tianjin, Tianjin Municipality, 300020, China
Tianjin Medical University Eye Hospital

Tianjin, Tianjin Municipality, 300384, China
Tongren Hospital Shanghai Jiao Tong University School Of Medicine

Shanghai, Shanghai Municipality, 200336, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China
Weifang Eye Hospital

Weifang, Shandong, 261041, China
West China Hospital, Sichuan University

Chengdu, Sichuan, 610041, China
Xi'an NO.1 Hospital

Xi'an, Shaanxi, 710002, China
Xi'an People's Hospital (Xi'an Fourth Hospital

Xi'an, Shaanxi, 710004, China
Xiamen Eye Center Affiliated to Xiamen University

Xiamen, Fujian, 361003, China
Xiangya Hospital of Central South University

Changsha, Hunan, 410008, China
Yanbian University Hospital

Yanji, Jilin, 133000, China
Zhengzhou Second Hospital

Zhengzhou, Henan, 450015, China
Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430071, China
Zhongshan Ophthalmic Center, Sun Yat-sen University

Guangzhou, Guangdong, 510060 / 510623, China

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