KERATOCONUS

This is the first human study of a new, permanent metal implant designed to reshape the cornea and improve vision in people with advanced keratoconus. The study will enroll 12 adults who are not candidates for other implants and are facing a corneal transplant. The main goal is t…

This study is testing whether a new eye drop called GLK-221 can safely slow or improve the corneal bulging caused by keratoconus. About 100 adults with keratoconus will use the drops or a placebo twice daily. Researchers will measure changes in the shape of the cornea to see if t…

This study is testing a new medical device called the PXL-Platinum 330 system. It uses a special light treatment called corneal cross-linking to try to stop progressive thinning and bulging of the cornea in conditions like keratoconus. Researchers will enroll 500 patients aged 10…

This study is testing an experimental treatment called corneal crosslinking (CXL) for people with Down syndrome who also have conditions that cause the clear front part of the eye (cornea) to thin and bulge, leading to worsening vision. The treatment involves applying vitamin B2 …

This study is testing two different laser procedures, both combined with a treatment to strengthen the cornea, for people with keratoconus. Keratoconus is an eye disease that thins and warps the cornea, causing blurry vision. Researchers want to see which combination is better at…

This study is testing a laser procedure to strengthen the cornea and improve vision in people with keratoconus, a condition where the cornea thins and bulges. Researchers will use advanced imaging to guide the laser treatment more precisely. The main goal is to see how much visio…

This study is testing a new, reversible eye implant made from pig collagen for people with severe keratoconus or post-LASIK ectasia, conditions that thin and bulge the cornea. The goal is to see if the implant is safe and can help stabilize the cornea and improve vision for patie…

This study is testing if a shorter 18-minute ultraviolet light treatment works as well as the standard 24-minute treatment to stop the progression of certain eye diseases that cause the clear front of the eye (cornea) to thin and bulge, leading to blurred vision. The treatment, c…

This study is testing a new type of microscope that scans the cornea to measure its stiffness. Researchers want to see if this scan can better detect early signs of corneal weakening diseases like keratoconus and ectasia. They will compare scans from people with healthy eyes to t…

This study is testing whether a special eye imaging technology called OCT can help doctors fit scleral contact lenses better for people with irregular corneas, such as those with keratoconus or after certain eye surgeries. Researchers will compare the fit of lenses chosen using t…

This study aims to improve how doctors detect, monitor, and treat irregular corneas, which can cause blurry vision. Researchers will use a special, detailed eye scan called OCT to create a better system for classifying these conditions and guiding a laser treatment. The goal is t…

This study aims to better understand keratoconus, an eye condition where the cornea thins and bulges. Researchers will observe 200 participants for two years to see how the disease progresses and identify factors like eye rubbing or allergies that might influence it. The study wi…

This study aims to understand why some patients develop long-term pain after a common eye surgery for keratoconus. Researchers will use brain scans and special eye imaging to track how pain signals change and how nerves in the eye heal after the procedure. The goal is to learn ho…

This study aims to develop better tools to predict how a person's cornea will respond to surgery. Researchers will use special eye imaging and computer simulations on people with keratoconus or those scheduled for LASIK. The goal is to see if these computer models can accurately …

This study aims to test new, high-tech eye imaging systems that can see microscopic details of the eye, like individual cells and blood flow, which are not visible with standard equipment. Researchers will enroll 1,200 participants, including people with various eye conditions an…