New light therapy aims to halt cornea disease and save sight

NCT ID NCT04094090

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a device that uses riboflavin (vitamin B2) drops and UV light to stiffen the cornea, the clear front part of the eye. It is for people with keratoconus or similar conditions that cause the cornea to bulge and blur vision. The goal is to see if the treatment safely improves vision and stops the disease from getting worse. About 500 participants aged 10 and older will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

riboflavin solution and UV-A light (corneal cross-linking)

What this could lead to

If successful, this could provide a safe, effective way to strengthen the cornea and slow or stop vision loss from keratoconus and similar conditions.

What could go wrong

This is a mid-stage trial, so results are not yet proven. The procedure may not work for everyone, and risks include infection, scarring, or temporary vision changes.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

corneal ectasia keratoconus pellucid marginal degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Goodman Eye Center

    RECRUITING

    San Francisco, California, 94115, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact