Promising new eye treatment could halt vision loss from keratoconus

NCT ID NCT06100939

Completed Disease control Sponsor: Epion Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested a new way to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The treatment uses special eye drops and ultraviolet light to strengthen the cornea without removing its outer layer. 396 people aged 8 to 45 took part to see if this approach can safely stop the disease from getting worse and improve vision.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Riboflavin and sodium iodide eye drops plus ultraviolet-A light treatment
What this could lead to: If successful, this could offer a less painful, faster-recovery treatment to stop keratoconus from getting worse and help preserve vision.
What could go wrong: This is a phase 3 trial, but results are not yet published. The treatment may not work for everyone, and there are risks like infection or corneal haze.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

keratoconus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KERATOCONUS

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Boston Vision

Brookline, Massachusetts, 02445, United States
Center for Excellence in Eye Care

Miami, Florida, 33176, United States
Chicago Cornea Consultants

Hoffman Estates, Illinois, 60169, United States
Cincinnati Eye Institute

Cincinnati, Ohio, 45219, United States
Devers Eye Institute

Portland, Oregon, 97210, United States
Goodman Eye Center

San Francisco, California, 94115, United States
Nvision Eye Centers Rowland Heights

Rowland Heights, California, 91748, United States
Ophthalmology Associates

St Louis, Missouri, 63131, United States
The Eye Doctors at CNY Eye Care

East Syracuse, New York, 13057, United States
UPMC Vision Institute

Pittsburgh, Pennsylvania, 15219, United States
University of Virginia

Charlottesville, Virginia, 22903, United States
Wills Eye Hospital

Philadelphia, Pennsylvania, 19107, United States

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