KERATOCONUS

This study tests a device that uses ultraviolet light and riboflavin (vitamin B2) drops to stiffen the cornea, the clear front part of the eye. It is for people aged 10 and older with keratoconus or similar conditions that cause the cornea to bulge and thin, leading to blurry vis…

This study tests a new implant made from pig collagen for people with severe keratoconus or post-LASIK ectasia, conditions that cause the cornea to bulge and blur vision. The implant is placed inside the cornea to improve its shape and stability. The goal is to see if it is safe …

This study tests an experimental eye drop called GLK-221 for people with keratoconus, a condition where the cornea thins and bulges into a cone shape, blurring vision. The trial will enroll 100 adults aged 18 to 55 and compare the eye drop to a placebo over several months. The ma…

This early study tests a small metal device implanted in the cornea to treat advanced keratoconus, a condition where the eye's front surface bulges and blurs vision. The goal is to flatten the cornea and improve sight, potentially avoiding the need for a corneal transplant. The s…

This study tests an experimental eye treatment called corneal crosslinking (CXL) for people with Down syndrome who have a condition that makes the front of the eye thin and misshapen, causing blurry vision. The treatment uses vitamin B2 drops and ultraviolet light to strengthen t…

This study tests a laser-based corneal cross-linking procedure to improve vision in 100 people with keratoconus, a condition that thins and bulges the cornea. The treatment uses OCT imaging to guide the laser precisely. The main goal is to see how much vision improves 6 months af…

This study tests whether adding a custom laser vision correction (PRK) to a standard corneal strengthening procedure (cross-linking) improves eyesight more than the strengthening procedure alone in people with keratoconus. About 50 adults aged 18-40 with mild to moderate keratoco…

This study tests INTACS prescription inserts, small plastic implants placed in the cornea, to reduce astigmatism and other vision problems caused by keratoconus. The goal is to improve vision enough so that participants, who are 21 or older and have no other option besides a corn…

This study tests a treatment called corneal crosslinking (CXL) for people with keratoconus and similar conditions that cause the cornea to thin and bulge, blurring vision. CXL uses vitamin B2 eye drops and UV light to strengthen the cornea and stop the disease from getting worse.…

This study tests a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of healthy volunteers and patients with these diseases to compare tissue stiffness. The goal is to d…

This study aims to improve how doctors detect and treat irregularly shaped corneas caused by conditions like keratoconus, dry eye, and scars. Researchers will use a special imaging technique called optical coherence tomography (OCT) to create a better classification system and gu…

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, for two years. Researchers will measure changes in the cornea, vision, and tear proteins, and look at risk factors like eye rubbing and allergies. Some participants will have surgery (cr…

This study aims to develop imaging tools and computer simulations that predict how a person's cornea (the clear front part of the eye) will change after treatments like LASIK or corneal crosslinking. Researchers will image the eyes of 60 participants with keratoconus or those sch…

This study follows up to 5,000 people with keratoconus, a condition that thins and bulges the cornea. Researchers will use special eye scans to measure how the cornea changes with age. The goal is to better understand how the disease starts and progresses, not to test a new treat…

This study tests whether a special imaging technique (OCT) can help fit scleral contact lenses more accurately than the current standard method. About 258 people with conditions like keratoconus or previous eye surgery will have two lens fittings—one using the standard method and…

This study looks at how pain signals in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye microscopes to track healing in 60 people aged 8-35. The goal is to understand pain bet…

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…