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Eye transplant showdown: which corneal procedure gives better vision?

NCT ID NCT06818747

Recruiting now Disease control Sponsor: Centre Hospitalier Régional Metz-Thionville Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of corneal transplants—PKP and DSAEK—in 334 adults aged 50+ with advanced bullous pseudophakic keratopathy, a condition where the cornea swells and blurs vision. Participants are randomly assigned to one procedure and followed for 2 years to see which provides better visual acuity. The goal is to identify the more effective surgical option for restoring sight.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Corneal transplant procedure (either PKP or DSAEK)
What this could lead to
If this trial succeeds, it could show which corneal transplant method gives better vision recovery for people with advanced bullous keratopathy.
What could go wrong
This is a comparative effectiveness trial, not a test of a new drug. Results may not apply to all patients, and both procedures carry risks like graft rejection or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bullous keratopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BULLOUS PSEUDOPHAKIC KERATOPATHY PENETRATING KERATOPLASTY

Contacts and locations

Locations

  • APHP - Hopital Cochin

    NOT_YET_RECRUITING

    Paris, 75014, France

  • CHR Metz-Thionville Hopital de Mercy

    RECRUITING

    Metz, 57085, France

  • CHRU Strasbourg - Nouvel Hôpital Civil

    RECRUITING

    Strasbourg, 67091, France

  • CHRU Tours

    RECRUITING

    Tours, 37044, France

  • CHU Besançon - Hôpital Jean Minjoz

    RECRUITING

    Besançon, 25030, France

  • CHU Bordeaux - Hopital Pellegrin

    RECRUITING

    Bordeaux, 33076, France

  • CHU Brest - Hopital Morvan

    RECRUITING

    Brest, 29609, France

  • CHU Nantes - Hôpital Hotel-Dieu

    NOT_YET_RECRUITING

    Nantes, 44000, France

  • CHU Saint-Etienne - Hôpital Nord

    RECRUITING

    Saint-Etienne, 42055, France

  • CHU Toulouse - Hopital Purpan

    RECRUITING

    Toulouse, 31059, France

  • Chno Xv Xx

    NOT_YET_RECRUITING

    Paris, 75571, France

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