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New eye drops aim to repair cornea damage in rare vision disorder

NCT ID NCT06452316

Recruiting now Disease control Sponsor: Claris Biotherapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This early-stage trial is testing an experimental eye drop called CSB-001 in 75 people with limbal stem cell deficiency, a condition where the eye's surface can't heal properly, leading to pain and vision loss. The study will check if the drops are safe and if they help improve signs of the disease. Participants will receive the drops in two separate dosing periods with a break in between, followed by a period of observation only.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CSB-001 ophthalmic solution (a modified human growth factor protein)
What this could lead to
If successful, this could point toward a new treatment option for limbal stem cell deficiency, a condition that can cause vision loss.
What could go wrong
This is a very early Phase 1 trial with only 75 people, focused mainly on safety. It is too soon to know if the drug works, and many early-stage treatments do not pan out.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

limbal stem cell deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIMBAL STEM CELL DEFICIENCY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Francis Price Jr, MD

    RECRUITING

    Indianapolis, Indiana, 46260, United States

  • Legacy Devers Eye Institute

    RECRUITING

    Portland, Oregon, 97210, United States

  • Loma Linda University Eye Institute

    RECRUITING

    Loma Linda, California, 92354, United States

  • Midwest Cornea Associates, LLC

    RECRUITING

    Carmel, Indiana, 46290, United States

  • Minnesota Eye Consultants

    RECRUITING

    Minnetonka, Minnesota, 55305, United States

  • Stuart A. Terry, MD PA

    RECRUITING

    San Antonio, Texas, 78212, United States

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